Characterization of Adenovirus Genome Type 7h: Analysis of Its Relationship to Other Members of Serotype 7

Kajon, Adriana E.; Wadell, Göran

doi:10.1159/000150235

Cited by 21 publications

(11 citation statements)

References 9 publications

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“…All U.S. (and eastern Ontario, Canada) Ad7d2 isolates and an Ad7d2 reference strain from Israel ( 37 ) gave identical restriction patterns for Bam HI, BcI I, Bgl I, Bgl II, Bst EII , Eco RI, Hpa I, Hin dIII, Sal I, Sma I, Xba I, and Xho I. Identical restriction profiles were also obtained with four U.S. Ad7h isolates and a 1998 isolate of Ad7h from Chile, which were similar to profiles described for Ad7h strains isolated in Argentina and Chile (formerly designated Ad3f) ( 41 , 42 , 44 ). …”

Section: Resultssupporting

confidence: 62%

“…Cases of severe pneumonia and neurologic disease were reported from a recent regional epidemic of Ad7d2 in Japan ( 15 ), but there was no evidence that these severe cases were more common than those reported for outbreaks involving other Ad7 genome types. Ad7h, a genetically unique recombinant between Ad7 and Ad3 ( 42 ), has been linked to increased illness and death in infants in Chile and Argentina, where it is second only to Human respiratory syncytial virus as a cause of severe viral pneumonia in infants and young children ( 34 , 52 ). However, in this study, too few cases of Ad7h infection were identified to assess differences in disease severity.…”

Section: Discussionmentioning

confidence: 99%

“…Restriction fragment size(s) was interpolated from DNA molecular weight standards included in each run. Restriction patterns were compared with previously published profiles ( 24 , 37 , 41 , 42 ), and the identification of genome types followed the denomination system of Li et al ( 24 ).…”

Section: Methodsmentioning

confidence: 99%

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Molecular Epidemiology of Adenovirus Type 7 in the United States, 1966–20001

Erdman

Xu²,

Gerber³

et al. 2002

Emerg. Infect. Dis.

134

109

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Genetic variation among 166 isolates of human adenovirus 7 (Ad7) obtained from 1966 to 2000 from the United States and Eastern Ontario, Canada, was determined by genome restriction analysis. Most (65%) isolates were identified as Ad7b. Two genome types previously undocumented in North America were also identified: Ad7d2 (28%), which first appeared in 1993 and was later identified throughout the Midwest and Northeast of the United States and in Canada; and Ad7h (2%), which was identified only in the U.S. Southwest in 1998 and 2000. Since 1996, Ad7d2 has been responsible for several civilian outbreaks of Ad7 disease and was the primary cause of a large outbreak of respiratory illness at a military recruit training center. The appearance of Ad7d2 and Ad7h in North America represents recent introduction of these viruses from previously geographically restricted areas and may herald a shift in predominant genome type circulating in the United States.

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Section: Resultssupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Epidemiology of Adenovirus Type 7 in the United States, 1966–20001

Erdman

Xu²,

Gerber³

et al. 2002

Emerg. Infect. Dis.

134

109

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“…Nevertheless, epidemiological studies indicate that the global prevalence patterns of HAdV genome types do shift over time and geographical region (10,18,27,28). This, along with the genome data presented here, suggests that it is advisable and prudent to design HAdV vaccines from strains that offer the greatest protection against the prevalent genome type and to continue surveillance and vaccine redevelopment with periodic evaluations of current field strains.…”

Section: Vol 43 2005 Genomes Of Two Adenovirus Vaccines 3089mentioning

confidence: 74%

Genomic and Bioinformatics Analyses of HAdV-4vac and HAdV-7vac, Two Human Adenovirus (HAdV) Strains That Constituted Original Prophylaxis against HAdV-Related Acute Respiratory Disease, a Reemerging Epidemic Disease

Purkayastha

McGraw

et al. 2005

J Clin Microbiol

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Vaccine strains of human adenovirus serotypes 4 and 7 (HAdV-4vac and HAdV-7vac) have been used successfully to prevent adenovirus-related acute respiratory disease outbreaks. The genomes of these two vaccine strains have been sequenced, annotated, and compared with their prototype equivalents with the goals of understanding their genomes for molecular diagnostics applications, vaccine redevelopment, and HAdV pathoepidemiology. These reference genomes are archived in GenBank as HAdV-4vac (35,994 bp; AY594254) and HAdV-7vac (35,240 bp; AY594256). Bioinformatics and comparative whole-genome analyses with their recently reported and archived prototype genomes reveal six mismatches and four insertions-deletions (indels) between the HAdV-4 prototype and vaccine strains, in contrast to the 611 mismatches and 130 indels between the HAdV-7 prototype and vaccine strains. Annotation reveals that the HAdV-4vac and HAdV-7vac genomes contain 51 and 50 coding units, respectively. Neither vaccine strain appears to be attenuated for virulence based on bioinformatics analyses. There is evidence of genome recombination, as the inverted terminal repeat of HAdV-4vac is initially identical to that of species C whereas the prototype is identical to species B1. These vaccine reference sequences yield unique genome signatures for molecular diagnostics. As a molecular forensics application, these references identify the circulating and problematic 1950s era field strains as the original HAdV-4 prototype and the Greider prototype, from which the vaccines are derived. Thus, they are useful for genomic comparisons to current epidemic and reemerging field strains, as well as leading to an understanding of pathoepidemiology among the human adenoviruses.

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“…This same genotype was found to become prevalent in Chile during 1986 (Kayon & Suarez 1990). Later, Niel et al (1991) ognized (Kayon & Wadell 1992) as the same virus and belonging to serotype 7, genetic type 7h.…”

mentioning

confidence: 74%