Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum

Vuerinckx, Kristel; Verlinden, Heleen; Lindemans, Marleen; Broeck, Jozef Vanden; Huybrechts, Roger

doi:10.1016/j.ibmb.2011.06.003

Cited by 43 publications

(43 citation statements)

References 43 publications

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“…In haematophagous insects, like T. infestans, secretion of an AT-like peptide by the Malpighian tubules stimulates peristaltic contractions of the hindgut in an endocrine way, facilitating the mixing of urine and faeces, and inducing the voiding during postprandial diuresis Ronderos 2007, 2009). An immediate increase in tonus and frequency of gut contractions was also observed ex vivo and in vivo after administering the T. castaneum ATlike peptide (Vuerinckx et al 2011). Also in Lepidopteran species such as H. armigera and the bright-line brown-eye (Lacanobia oleracea (L., 1758)), AT was shown to stimulate gut contractions (Duve et al , 2000.…”

Section: Allatoregulatory Peptidesmentioning

confidence: 81%

“…ATs exert their effects on their cellular targets by binding to high-affinity receptors, which are members of the GPCR superfamily Horodyski et al 2011;Nouzova et al 2011;Vuerinckx et al 2011). In A. aegypti, an AT receptor was characterized and found to be expressed in the CC, but also in the heart, hindgut, accessory glands, and testes (Nouzova et al 2011).…”

Section: Allatoregulatory Peptidesmentioning

confidence: 99%

“…In feeding larvae of M. sexta, an AT receptor is predominantly expressed in the Malpighian tubules, followed by relatively high expression in both midgut and hindgut, the corpora allata, and the testes (Horodyski et al 2011). The AT-like peptide receptor of T. castaneum is expressed in the head, gut, fat body, and the reproductive system (Vuerinckx et al 2011). …”

Section: Allatoregulatory Peptidesmentioning

confidence: 99%

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Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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Like all heterotrophic organisms, insects require a strict control of food intake and efficient digestion of food into nutrients to maintain homeostasis and to fulfill physiological tasks. Feeding and digestion are steered by both external and internal signals that are transduced by a multitude of regulatory factors, delivered either by neurons innervating the gut or mouthparts, or by midgut endocrine cells. The present review gives an overview of peptide regulators known to control feeding and digestion in insects. We describe the discovery and functional role in these processes for insect allatoregulatory peptides, diuretic hormones, FMRFamide-related peptides, (short) neuropeptide F, proctolin, saliva production stimulating peptides, kinins, and tachykinins. These peptides control either gut myoactivity, food intake, and (or) release of digestive enzymes. Some peptides exert their action at multiple levels, possibly having a biological function that depends on their site of delivery. Many regulatory peptides have been physically extracted from different insect species. However, multiple peptidomics, proteomics, transcriptomics, and genome sequencing projects have led to increased discovery and prediction of peptide (precursor) and receptor sequences. In combination with physiological experiments, these large-scale projects have already led to important steps forward in unraveling the physiology of feeding and digestion in insects.Key words: insect, midgut, digestion, neuropeptides, stomatogastric nervous system. Résumé : Comme tous les organismes hétérotrophes, les insectes requièrent un contrôle strict de leur ingestion de nourriture et la digestion de leur nourriture en nutriments afin de maintenir leur homéostasie et de compléter leurs tâches physiologiques. L'alimentation et la digestion sont gouvernées par des signaux tant externes qu'internes qui sont transmis par un multitude de facteurs régulateurs, livrés ou bien par les neurones qui innervent le tube digestif ou les pièces buccales ou alors par les cellules endocrines du tube digestif moyen. Notre revue fournit une synthèse des régulateurs peptidiques connus pour contrôler l'alimentation et la digestion chez les insectes. Nous décrivons la découverte et le rôle fonctionnel de ces processus dans le cas des peptides allatorégulateurs, des hormones diurétiques, des peptides apparentés aux amides FMRF, du neuropeptide F (court), de la proctoline, des peptides stimulateurs de la production de salive, des kinines et des tachykinines des insectes. Ces peptides contrôlent la myoactivité du tube digestif, l'ingestion de nourriture et(ou) la libération des enzymes digestives. Certains peptides agissent à de multiples niveaux, possédant une fonction biologique qui dépend de leur site d'action. Plusieurs peptides régulateurs ont été extraits physiquement de différentes espèces d'insectes. Cependant, plusieurs projets de peptidomique, de protéomique, de transcriptomique et de génomique ont mené à de nombreuses découvertes supplémentaires et des prédict...

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Section: Allatoregulatory Peptidesmentioning

confidence: 81%

Section: Allatoregulatory Peptidesmentioning

confidence: 99%

Section: Allatoregulatory Peptidesmentioning

confidence: 99%

See 1 more Smart Citation

Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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“…Mammalian expression of the T. casteneum AT receptor showed activation with the native Trica-AT but was less sensitive to activation by Manse-AT. Manse ATL-1-3 did not effectively activate the receptor (Vuerinckx et al 2011). The A. aegypti AT receptor was identified based on the selection of receptors expressed in the CC/CA that exhibited mRNA expression levels that increased for 24 h after eclosion, to mimic the change in JH biosynthesis.…”

Section: Notementioning

confidence: 94%

“…BNGR-16 was described as the functional receptor in B. mori (Yamanaka et al 2008), and the two paralogous receptor genes in A. aegypti encode nearly identical receptor sequences (Nouzova et al 2011). One receptor has been identified in M. sexta (Horodyski et al 2011) and T. castaneum (Vuerinckx et al 2011). Expression of the Manse-AT receptor in mammalian cells identified Manse-ATL-1 as the most potent peptide.…”

Section: Notementioning

confidence: 99%

Families of allatoregulator sequences: a 2011 perspective¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

BendenaWilliam

TobeStephen

2012

Can. J. Zool.

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Three different peptide families have been named "allatostatins" (ASTs), based on their initial purifications which were based on their ability to inhibit juvenile hormone (JH) biosynthesis. These include (i) a family of peptides that have a consensus C-terminal sequence Y/FXFGL-NH 2 ; (ii) a family of peptides with a conserved C-terminal sequence W(X) 6 W-NH 2 ; and(iii) a family of peptides with C-terminal sequence PISCF, some of which are C-terminally-amidated. Each allatostatin family has functions distinct and apart from the inhibition of JH biosynthesis. A peptide family known as the "allatotropins" serve to stimulate JH biosynthesis. This family of peptides also has been proven to exert multiple effects dependent on the species in question. Genome and peptidome projects are uncovering new members of these families and it is clear that these structures are not just confined to Insecta but are found in a range of invertebrates. The receptors for these neuropeptides have been identified and tested experimentally for specific ligand binding. The Y/FXFGLa-ASTs exert their action through galanin-like receptors, W(X) 6 Wa-ASTs through a sex peptide-binding receptor, and PISCF-ASTs through somatostatin-like receptors. These receptors are conserved through evolutionary time and are being identified in numerous invertebrates by way of genome projects.Key words: allatostatin, allatotropin, juvenile hormone, muscle contraction, neuropeptides, neuropeptide receptors, insects, crustaceans, arthropods.Résumé : Trois familles différentes de peptides portent le nom d'« allatostatines » (AST) d'après leurs purifications initiales basées sur leur capacité d'inhiber la biosynthèse de l'hormone juvénile (JH). Elles incluent (i) une famille de peptides qui possèdent une séquence consensus C-terminale Y/FXFGL-NH 2 , (ii) une famille de peptides avec une séquence C-terminale conservée W(X) 6 W-NH 2 et (iii) une famille de peptides avec une séquence C-terminale PISCF, dont certains sont amidatées sur l'extrémité C-terminale. Chaque famille d'allatostatines possède des fonctions distinctes et additionnelles à l'inhibition de la synthèse de l'hormone juvénile. Une famille de peptides connus sous le nom d'« allatotropines » sert à stimuler la synthèse de la JH. Cette famille de peptides produit aussi des effets multiples selon l'espèce concernée. Des projets sur le génome et le peptidome découvrent de nouveaux membres de ces familles et il est clair que ces structures ne se retrouvent pas seulement chez les insectes, mais aussi chez une gamme d'invertébrés. Les récepteurs de ces neuropeptides ont été identifiés et ont été testé expérimentalement pour des liaisons spécifiques au ligand. Les AST-Y/FXFGLa exercent leur action par des récepteurs de type galanine, les AST-W(X)6Wa par un récepteur liant un peptide sexuel et les AST-PISCF par des récepteurs de type somatostatine. Ces récepteurs sont conservés au cours de l'évolution et sont présentement retrouvés chez de nombreux invertébrés dans le cadre des projets de génome.

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Endocrine Regulation of Insect Digestion

Terra,

Ferreira,

Silva

2023

Entomology in Focus

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Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum

Cited by 43 publications

References 43 publications

Endocrine Regulation of Insect Digestion

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