Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1

Abstract

Six monoclonal antibodies directed against EHV-1 glycoprotein 13 were characterized. Five antibodies neutralized EHV-1 and were directed against a single antigenic site which comprised type-specific and type cross-reactive epitopes. Inhibition of monoclonal antibody binding to this site by post-infection equine sera suggests that it is a target of host antibody during natural infection with either EHV-1 or EHV-4.