Characterization of an Integrated Fluorescence-Detection Hybrid Device With Photodiode and Organic Light-Emitting Diode

Shin, Kyung Sook; Kim, Young‐Hwan; Paek, Kyeong-Kap; Park, Jung Ho; Yang, Eungyeong; Kim, Tae-Song; Kang, Jungwon; Ju, Byeong−Kwon

doi:10.1109/led.2006.880656

Cited by 27 publications

(13 citation statements)

References 15 publications

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“…Optical techniques would then only be required to detect binding between probe and target molecules (most likely using conventional fluorescent labels). Because this is possible using a simple optical detector such as a photodiode [13], the bulky imaging optics and image analysis systems required by the technologies described above would not be necessary.…”

Section: Introductionmentioning

confidence: 99%

Magnetic micro-barcodes for molecular tagging applications

Hayward

Hong

Vyas

et al. 2010

J. Phys. D: Appl. Phys.

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We describe proof-of-principle experiments and theory that demonstrate a new method of performing multiplexed biological assays by using microscopic tags which carry multi-bit magnetic codes to label probe biomolecules. It is demonstrated that these "micro-barcode tags" can be encoded, transported using micro-fluidics and are compatible with surface chemistry. We also present simulations and experimental results which suggest the feasibility of decoding the micro-barcode tags using magnetoresistive sensors. Together, these results demonstrate substantial progress towards meeting the critical requirements of a magnetically encoded, high-throughput and portable biological assay platform. We also show that an extension of our technology could be potentially used to label libraries consisting of~10 4 distinct probe molecules, and could therefore have a strong impact on mainstream medical diagnostics.

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Section: Introductionmentioning

confidence: 99%

Magnetic micro-barcodes for molecular tagging applications

Hayward

Hong

Vyas

et al. 2010

J. Phys. D: Appl. Phys.

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“…Highlighting the need to miniaturize their entire LoC system, Shin and Kim et al investigated a fully integrated microfluidic system with an Alq 3 OLED excitation source and a p-i-n Si PD [71,72]. The microchannel itself was etched in glass, and the OLED was deposited onto the same glass substrate.…”

Section: Organic Light Emitting Diode-integrated Lab-on-a-chip Systemsmentioning

confidence: 99%

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

2014

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The rapid development of microfluidics and lab-on-a-chip (LoC) technologies have allowed for the efficient separation and manipulation of various biomaterials, including many diagnostically relevant species. Organic electronics have similarly enjoyed a great deal of research, resulting in tiny, highly efficient, wavelength-selective organic light-emitting diodes (OLEDs) and organic photodetectors (OPDs). We consider the blend of these technologies for rapid detection and diagnosis of biological species. In the ideal system, optically active or fluorescently labelled biological species can be probed via light emission from OLEDs, and their subsequent light emission can be detected with OPDs. The relatively low cost and simple fabrication of the organic electronic devices suggests the possibility of disposable test arrays. Further, with full integration, the finalized system can be miniaturized and made simple to use. In this review, we consider the design constraints of OLEDs and OPDs required to achieve fully organic electronic optical bio-detection systems. Current approaches to integrated LoC optical sensing are first discussed. Fully realized OLED-and OPD-specific photoluminescence detection systems from literature are then examined, with a specific focus on their ultimate limits of detection. The review highlights the enormous potential in OLEDs and OPDs for integrated optical sensing, and notes the key avenues of research for cheap and powerful LoC bio-detection systems.

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“…A number of techniques for miniaturizing the NSOM probes have been developed using MEMS. Light absorbing gold particles [29] and fluorescent beads [30] have been attached to the scanning tips to improve the resolution of the NSOM tips. The resolutions of these have been determined by the spherical diameters of the attached particle.…”

Section: Near-field Scanning Microscopymentioning

confidence: 99%

Quantum dots light emitting devices on MEMS: microcontact printing, near-field imaging, and early cancer detection

Gopal

Hoshino

Zhang

2011

International Symposium on Photoelectronic Detection and Imaging 2011: Sensor and Micromachined Optical Device Technologies

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Controlled patterning of light emitting devices on semiconductors and micro-electro-mechanical systems (MEMS) enables a vast variety of applications such as structured illumination, large-area flexible displays, integrated optoelectronic systems and micro-total analysis systems for real-time biomedical screening. We have demonstrated a series of techniques of creating quantum dot-based (QD) patterned inorganic light emitting devices at room temperature on silicon (Si) substrate. The innovative technology was translated to create localized QD-based light sources for two applications: (1) Three-dimensional scanning probe tip structures for near field imaging. Combined topographic and optical images were acquired using this new class of "self-illuminating" probe in commercial NSOM. The emission wavelength can be tuned through quantum-size effect of QDs. (2) Multispectral excitation sources integrated with microfluidic channels for tumor cell analyses. We were able to detect the variation of sub-cellular features, such as the nucleus-to-cytoplasm ratio, to quantify the absorption at different wavelength upon the near-field illumination of individual tumor cells towards the determination of cancer developmental stage.Keywords： quantum dots, LED, microcontact printing, micro-electro-mechanical systems (MEMS), silicon scanning probe, multispectral imaging, near field scanning optical microscopy, cancer detection.

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Characterization of an Integrated Fluorescence-Detection Hybrid Device With Photodiode and Organic Light-Emitting Diode

Cited by 27 publications

References 15 publications

Magnetic micro-barcodes for molecular tagging applications

Magnetic micro-barcodes for molecular tagging applications

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

Quantum dots light emitting devices on MEMS: microcontact printing, near-field imaging, and early cancer detection

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