Characterization of an unknown component in Noscapine using liquid chromatography–mass spectrometry and proton nuclear magnetic resonance spectroscopy

High-Throughput Screening of Drugs of Abuse in Urine by Supported Liquid–Liquid Extraction and UHPLC Coupled to Tandem MS

“…In addition, m/z 163 fragment was specific to MDEA whilst m/z 177 fragment was specific to MBDB. For noscapine, the major fragment was m/z 220, as reported elsewhere [33]. For morphine, fragments 157 and 185 were followed, in agreement with other studies [15].…”

Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples

“…Noscapine has been determined by chromatography, mass spectroscopy, IMS and synergetic methods. HPLC methods [18][19][20] or chromatography with tandem mass detection [7][8][9][10][11] do not have better detection limit, dynamic range, reproducibility (reproducibility in IMS technique is relatively low (R.S.D. = 11-13%) and cannot use in biological samples) and are expensive.…”

“…Different methods have been developed for the detection and determination of noscapine in plasma, urine, and opium samples include corona discharge ion mobility spectrometry [6], LC-MS [7][8][9], HPLC-MS/MS [10,11], LLE-MS/MS [12], flow injection chemiluminescence [13], adsorptive differential pulse stripping voltammetry [14], capillary electrophoresis (CE) [15,16], ATR-FT-IR and FT-Raman spectroscopy [17], high performance liquid chromatography (HPLC) [18][19][20] and spectrophotometry [21,22].…”

Online hyphenated liquid chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry for drug metabolite and nature product analysis

“…Its applications to metabolite and nature product analysis in the past 10 years are also reviewed. Studies without online LC, NMR and MS hyphenation are not included in the review; among those are, for example, studies performed on separated LC-MS and LC-NMR runs [22], or LC-MS followed by offline NMR determination [23]. The term LC-NMR-MS rather than LC-MS-NMR is preferred to designate this hyphenation in this article, because the analysis takes place in that order if the system is configured in series, and the limitations and improvements are always in the LC-NMR side.…”