2019
DOI: 10.1055/s-0039-1697000
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Characterization of Antimonium crudum Activity Using Solvatochromic Dyes

Abstract: Background The mechanism by which highly diluted and agitated solutions have their effect is still unknown, but the development in recent years of new methods identifying changes in water and solute dipole moments is providing insights into potential modes of action. Objective The objective of the current study was to compare the biological effects of Antimonium crudum (AC) previously obtained by our group and already described in the literature with now measurable physico-chemical effects on solvato… Show more

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Cited by 16 publications
(28 citation statements)
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“…18 Recently, correspondence between the effects of the homeopathic medicine Antimonium crudum on solvatochromic dyes and the effects of the same dilutions in an in vitro model using macrophages infected with Leishmania amazonensis 22 has been demonstrated. 20 This has opened up new avenues of study in the field of high dilution research and possible mechanisms of action, in which the effects of ultra-high dilutions on solvatochromic dyes could be considered as a physico-chemical indicator of their biological activity. 20 Moreover, this correspondence was in accordance with in vivo effects of the same medicine.…”
Section: Discussionmentioning
confidence: 99%
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“…18 Recently, correspondence between the effects of the homeopathic medicine Antimonium crudum on solvatochromic dyes and the effects of the same dilutions in an in vitro model using macrophages infected with Leishmania amazonensis 22 has been demonstrated. 20 This has opened up new avenues of study in the field of high dilution research and possible mechanisms of action, in which the effects of ultra-high dilutions on solvatochromic dyes could be considered as a physico-chemical indicator of their biological activity. 20 Moreover, this correspondence was in accordance with in vivo effects of the same medicine.…”
Section: Discussionmentioning
confidence: 99%
“…20 This has opened up new avenues of study in the field of high dilution research and possible mechanisms of action, in which the effects of ultra-high dilutions on solvatochromic dyes could be considered as a physico-chemical indicator of their biological activity. 20 Moreover, this correspondence was in accordance with in vivo effects of the same medicine. 21 Similar correlations have been described using ultra-high dilutions of Silicea terra and Phosphorus.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…3,4 Such medicines seem to present epigenetic effects since they are able to modulate intracellular signaling pathways [5][6][7][8][9] even though the nature of the involved signals has not yet been elucidated. [10][11][12][13][14] Macrophages play a key role in chronic inflammatory lesions and they have thus been widely used in experimental models to investigate such adaptive processes. 15,16 In addition, these cells seem to be highly sensitive to homeopathic medicines, [17][18][19][20][21][22][23][24] especially when exposed to biological agents that resist phagocytosis such as protozoa and Bacillus Calmette-Guérin (BCG, that is, attenuated Mycobacterium bovis).…”
Section: Introductionmentioning
confidence: 99%