Characterization of arterial flow mediated dilation via a physics-based model

Sidnawi, Bchara; Chen, Zhe; Sehgal, Chandra M.; Wu, Qianhong

doi:10.1016/j.jmbbm.2020.103756

Cited by 8 publications

(2 citation statements)

References 53 publications

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“…In addition to the exposure-response model, Sidnawi et al further modeled the vasodilating effect of NO by describing arterial stiffness as a function of WSS, and derived new parameters other than FMD% to represent the time response of arterial diameter and the arterial resistance to changing wall shear stress [67,68]. In addition, our group modeled the NO delivery process based on the advection-diffusion-reaction equation of NO transport, and considered deformation of the arterial wall, of which the stiffness is determined using NO concentration.…”

Section: Improving the Specificity Of The Flow-mediated Dilation Test In Assessing Endothelial Function Through Computational Modeling Ofmentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in the cardiovascular system, clinical applications centered on NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process, based on computational modeling and flow-mediated dilation, to assess endothelial function and vulnerability of atherosclerotic plaque. Then, emerging bioimaging technologies that have the potential to experimentally measure arterial NO concentration were discussed, including Raman spectroscopy and electrochemical sensors. In addition to diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the NO release platform to treat endothelial dysfunction and atherosclerosis and inhaled NO therapy to treat pulmonary hypertension and COVID-19. Two potential methods to improve the effectiveness of existing NO therapy were also discussed, including the combination of NO release platform and computational modeling, and stem cell therapy, which currently remains at the laboratory stage but has clinical potential for the treatment of CVD.

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Section: Improving the Specificity Of The Flow-mediated Dilation Test In Assessing Endothelial Function Through Computational Modeling Ofmentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Aside from the exposure-response model, Sidnawi et al further considered the vasodilating effect of NO by describing the arterial stiffness as a function of WSS, and derived the new parameters other than FMD% to represent the time response of arterial diameter and the arterial resistance to a changing wall shear stress [67,68]. Besides, our group modeled the NO delivery process based on the advection-diffusion-reaction equation of NO transport, and considered the deformation of arterial wall whose stiffness is determined by NO concentration.…”

Section: Mathematical Modeling Of No Delivery In Flow-mediated Dilation To Enhance the Specificity Of Endothelial Functionmentioning

confidence: 99%

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

Ma¹,

Zhang²,

Chen³

et al. 2021

Preprint

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of Coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in cardiovascular system, the clinical applications centered on the NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process based on the clinical images and mathematical modeling to assess the endothelial function and vulnerability of atherosclerotic plaque. Then, the emerging bioimaging technologies that have the potential to directly measure the arterial NO concentration were discussed, including the Raman spectroscopy and electrochemical sensor. Aside from the diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the inhaled NO therapy to treat the pulmonary hypertension and COVID-19, stem cell therapy and NO-releasing platform to treat endothelial dysfunction and atherosclerosis.

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A comprehensive physics-based model for the brachial Artery's full flow mediated dilation (FMD) response observed during the FMD test

Sidnawi,

Zhou,

Chen

et al. 2024

Computers in Biology and Medicine

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Characterization of arterial flow mediated dilation via a physics-based model

Cited by 8 publications

References 53 publications

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

A comprehensive physics-based model for the brachial Artery's full flow mediated dilation (FMD) response observed during the FMD test

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