Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Ma, Tianxiang; Zhang, Zhexi; Chen, Yu; Su, Haoran; Deng, Xiaoyan; Liu, Xiao; Fan, Yubo

doi:10.3390/ijms222212166

Cited by 19 publications

(21 citation statements)

References 156 publications

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“…The use of donor molecules provides another avenue for the delivery of NO. Numerous NO-releasing molecules that possess unique biophysical properties, half-life, and release kinetics that are dictated by specific stimuli (such as light, heat, and pH) have been developed [ 174 ]. In addition, the incorporation of NO into polymers through micelles, dendrimers, star-shaped polymers, and polymeric nanoparticles permits the liberation of NO in a more continuous fashion [ 175 ].…”

Section: Targeting Arginine In Covid-19mentioning

confidence: 99%

Targeting Arginine in COVID-19-Induced Immunopathology and Vasculopathy

Durante

2022

Metabolites

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Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has caused the death of nearly six million people worldwide. Emerging data have identified a deficiency of circulating arginine in patients with COVID-19. Arginine is a semi-essential amino acid that serves as key regulator of immune and vascular cell function. Arginine is metabolized by nitric oxide (NO) synthase to NO which plays a pivotal role in host defense and vascular health, whereas the catabolism of arginine by arginase to ornithine contributes to immune suppression and vascular disease. Notably, arginase activity is upregulated in COVID-19 patients in a disease-dependent fashion, favoring the production of ornithine and its metabolites from arginine over the synthesis of NO. This rewiring of arginine metabolism in COVID-19 promotes immune and endothelial cell dysfunction, vascular smooth muscle cell proliferation and migration, inflammation, vasoconstriction, thrombosis, and arterial thickening, fibrosis, and stiffening, which can lead to vascular occlusion, muti-organ failure, and death. Strategies that restore the plasma concentration of arginine, inhibit arginase activity, and/or enhance the bioavailability and potency of NO represent promising therapeutic approaches that may preserve immune function and prevent the development of severe vascular disease in patients with COVID-19.

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Section: Targeting Arginine In Covid-19mentioning

confidence: 99%

Targeting Arginine in COVID-19-Induced Immunopathology and Vasculopathy

Durante

2022

Metabolites

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“…Cardiovascular diseases have become one of the most dangerous factors for threatening human life [ 1 , 2 , 3 ]. According to investigation by the World Health Organization, about one-third of all deaths worldwide are caused by cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Self-Similar Functional Circuit Models of Arteries and Deterministic Fractal Operators: Theoretical Revelation for Biomimetic Materials

Peng

Guo

Yin

2021

IJMS

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In this paper, the self-similar functional circuit models of arteries are proposed for bioinspired hemodynamic materials design. Based on the mechanical-electrical analogous method, the circuit model can be utilized to mimic the blood flow of arteries. The theoretical mechanism to quantitatively simulate realistic blood flow is developed by establishing a fractal circuit network with an infinite number of electrical components. We have found that the fractal admittance operator obtained from the minimum repeating unit of the fractal circuit can simply and directly determine the blood-flow regulation mechanism. Furthermore, according to the operator algebra, the fractal admittance operator on the aorta can be represented by Gaussian-type convolution kernel function. Similarly, the arteriolar operator can be described by Bessel-type function. Moreover, by the self-similar assembly pattern of the proposed model, biomimetic materials which contain self-similar circuits can be designed to mimic physiological or pathological states of blood flow. Studies show that the self-similar functional circuit model can efficiently describe the blood flow and provide an available and convenient structural theoretical revelation for the preparation of in vitro hemodynamic bionic materials.

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“…NO-based therapies exhibit great potential as antimicrobials and antivirals in the acceleration of wound healing and anticancer treatment [ 2 , 3 , 4 , 5 ]. More recently, the potential of inhaled NO was also explored in COVID-19 treatment, since it can stabilize oxidation stress, which is the major cause of comorbidity deaths [ 6 , 7 , 8 ]. The most recognizable area in which NO is known to have significant influence is the cardiovascular system, where it regulates platelet aggregation, adhesion and vascular tone, and blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Nanomolar Nitric Oxide Concentrations in Living Cells Measured by Means of Fluorescence Correlation Spectroscopy

et al. 2022

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Measurement of the nitric oxide (NO) concentration in living cells in the physiological nanomolar range is crucial in understanding NO biochemical functions, as well as in characterizing the efficiency and kinetics of NO delivery by NO-releasing drugs. Here, we show that fluorescence correlation spectroscopy (FCS) is perfectly suited for these purposes, due to its sensitivity, selectivity, and spatial resolution. Using the fluorescent indicators, diaminofluoresceins (DAFs), and FCS, we measured the NO concentrations in NO-producing living human primary endothelial cells, as well as NO delivery kinetics, by an external NO donor to the immortal human epithelial living cells. Due to the high spatial resolution of FCS, the NO concentration in different parts of the cells were also measured. The detection of nitric oxide by means of diaminofluoresceins is much more efficient and faster in living cells than in PBS solutions, even though the conversion to the fluorescent form is a multi-step reaction.

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Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Cited by 19 publications

References 156 publications

Targeting Arginine in COVID-19-Induced Immunopathology and Vasculopathy

Targeting Arginine in COVID-19-Induced Immunopathology and Vasculopathy

Self-Similar Functional Circuit Models of Arteries and Deterministic Fractal Operators: Theoretical Revelation for Biomimetic Materials

Nanomolar Nitric Oxide Concentrations in Living Cells Measured by Means of Fluorescence Correlation Spectroscopy

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