Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior

Mckenna, James T; Yang, Chun; Bellio, Thomas; Anderson-Chernishof, Marissa B; Gamble, Mackenzie C.; Hulverson, Abigail; McCoy, John G.; Winston, Stuart; Hodges, Erik L.; Katsuki, Fumi; McNally, James M.; Basheer, Radhika; Brown, Ritchie E.

doi:10.1007/s00429-021-02288-7

Cited by 17 publications

(31 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The basal forebrain is a node with various functions, including sensory processing, attention, motivation, learning, and memory 18,25,[28][29][30][31][32][33][34][35] . Previously, we and others have independently revealed the BF to have roles in appetite suppression and aversive behaviors [12][13][14]26 . One of the ways the BF may drive distinct behaviors is through its differential projections.…”

Section: Discussionmentioning

confidence: 89%

“…The inability for vGlut2 BF→LHb aversion to be associated with contextual cues or generate a hormonal stress response is therefore somewhat surprising. However, independent studies have revealed aversion elicited by BF cell bodies also does not drive conditioned place preference 26 , indicating that BF-driven aversion does not appear to be remembered. Even more surprising, optogenetic stimulation of vGlut2 BF→LHb circuitry following novel object recognition training completely impaired object discrimination, indicating that vGlut2 BF→LHb circuitry actively inhibits memory formation.…”

Section: Discussionmentioning

confidence: 99%

“…One of the ways the BF may drive distinct behaviors is through its differential projections. Targets of the BF include sensory regions such as the piriform cortex, feeding-associated regions such as the hypothalamus, and reward/aversion-associated regions such as the basolateral amygdala, ventral tegmental area, and lateral habenula 12 , 13 , 26 . While this study focused on the role of BF projections to the LHb in aversion and feeding, previous studies have shown that BF projections to the LHA also drive aversion and hypophagia 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Lateral habenula projecting glutamatergic basal forebrain neurons drive aversive behaviors. Since the glutamatergic BF has been shown to mediate aversion 12,26 , we next asked whether optogenetic activation of vGlut2 BF→LHb terminals mediate aversive behavior. To test this, we subjected LHb-implanted optogenetic mice (Fig.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior

Swanson

Ortiz-Guzman

Srivastava

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related odors. Optogenetic activation of BF-to-LHb circuitry drives robust, reflexive-like aversion. Furthermore, activation of this circuitry suppresses the drive to eat in a fasted state. Together, these data reveal a role of basal forebrain glutamatergic neurons in modulating LHb-associated aversion and feeding behaviors by sensing environmental cues.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior

Swanson

Ortiz-Guzman

Srivastava

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…VTA projecting VP PV neurons are preferentially innervated by the basal ganglia and central amygdala, whereas lHb projecting VP PV neurons receive preferential inputs from the bed nucleus of the stria terminalis (Knowland et al, 2017 ). In addition to PV, VP neurons also express the calcium-binding proteins calretinin, calbindin, and secretagogin (Gritti et al, 2003 ; Zaborszky et al, 2012 ), and both calbindin and calretinin are expressed in a substantial number of VP Glu neurons (McKenna et al, 2021 ).…”

Section: Part 1: Neuroanatomy Of the Ventral Pallidummentioning

confidence: 99%

Ventral pallidal regulation of motivated behaviors and reinforcement

Soares‐Cunha

Heinsbroek

2023

Front. Neural Circuits

View full text Add to dashboard Cite

The interconnected nuclei of the ventral basal ganglia have long been identified as key regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in mood and substance use disorders. The ventral pallidum (VP) is a central node of the ventral basal ganglia, and recent studies have revealed complex VP cellular heterogeneity and cell- and circuit-specific regulation of reward, aversion, motivation, and drug-seeking behaviors. Although the VP is canonically considered a relay and output structure for this circuit, emerging data indicate that the VP is a central hub in an extensive network for reward processing and the regulation of motivation that extends beyond classically defined basal ganglia borders. VP neurons respond temporally faster and show more advanced reward coding and prediction error processing than neurons in the upstream nucleus accumbens, and regulate the activity of the ventral mesencephalon dopamine system. This review will summarize recent findings in the literature and provide an update on the complex cellular heterogeneity and cell- and circuit-specific regulation of motivated behaviors and reinforcement by the VP with a specific focus on mood and substance use disorders. In addition, we will discuss mechanisms by which stress and drug exposure alter the functioning of the VP and produce susceptibility to neuropsychiatric disorders. Lastly, we will outline unanswered questions and identify future directions for studies necessary to further clarify the central role of VP neurons in the regulation of motivated behaviors.Significance: Research in the last decade has revealed a complex cell- and circuit-specific role for the VP in reward processing and the regulation of motivated behaviors. Novel insights obtained using cell- and circuit-specific interrogation strategies have led to a major shift in our understanding of this region. Here, we provide a comprehensive review of the VP in which we integrate novel findings with the existing literature and highlight the emerging role of the VP as a linchpin of the neural systems that regulate motivation, reward, and aversion. In addition, we discuss the dysfunction of the VP in animal models of neuropsychiatric disorders.

show abstract

The role of the basal forebrain in general anesthesia

Peng

Yuan

Zhang

2022

Ibrain

View full text Add to dashboard Cite

The basal forebrain is a group of nerve nuclei on the ventral side of the ventral ganglion, composed of γ‐aminobutyric acid neurons, glutamatergic neurons, cholinergic neurons, and orexigenic neurons. Previous studies have focused on the involvement of the basal forebrain in regulating reward, learning, movement, sleep–awakening, and other neurobiological behaviors, but its role in the regulation of general anesthesia has not been systematically elucidated. Therefore, the different neuronal subtypes in the basal forebrain and projection pathways in general anesthesia will be discussed in this paper. In this paper, we aim to determine and elaborate on the role of the basal forebrain in general anesthesia and the development of theoretical research and provide a new theory.

show abstract

Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior

Cited by 17 publications

References 140 publications

Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior

Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior

Ventral pallidal regulation of motivated behaviors and reinforcement

The role of the basal forebrain in general anesthesia

Contact Info

Product

Resources

About