Characterization of breast tissue using energy-dispersive X-ray diffraction computed tomography

Pani, S.; Cook, Emily; Horrocks, Judith; Jones, J. Louise; Speller, Robert

doi:10.1016/j.apradiso.2010.04.027

Cited by 55 publications

(35 citation statements)

References 33 publications

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“…There is a growing need for rapid in situ materials discrimination in fields including medicine [1], security screening [2,3] and industrial process control [4]. X-ray diffraction (XRD) is the gold standard for conducting definitive materials discrimination because it provides the near unequivocal identification of material phase.…”

Section: Introductionmentioning

confidence: 99%

Energy-dispersive X-ray diffraction using an annular beam

Dicken¹,

Evans²,

Rogers³

et al. 2015

Opt. Express

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Abstract:We demonstrate material phase identification by measuring polychromatic diffraction spots from samples at least 20 mm in diameter and up to 10 mm thick with an energy resolving point detector. Within our method an annular X-ray beam in the form of a conical shell is incident with its symmetry axis normal to an extended polycrystalline sample. The detector is configured to receive diffracted flux transmitted through the sample and is positioned on the symmetry axis of the annular beam. We present the experiment data from a range of different materials and demonstrate the acquisition of useful data with sub-second collection times of 0.5 s; equating to 0.15 mAs. Our technique should be highly relevant in fields that demand rapid analytical methods such as medicine, security screening and non-destructive testing. 12. D. Prokopiou, K. Rogers, P. Evans, S. Godber, and A. Dicken, "Discrimination of liquids by a focal construct Xray diffraction geometry," Appl. Radiat. Isot. 77, 160-165 (2013). 13. P. Evans, K. Rogers, A. Dicken, S. Godber, and D. Prokopiou, "X-ray diffraction tomography employing an annular beam," Opt. Express 22(10), 11930-11944 (2014). 14. R. D. Luggar, J. A. Horrocks, R. D. Speller, and R. J. Lacey, "Determination of the geometric blurring of an energy dispersive X-ray diffraction (EDXRD) system and its use in the simulation of experimentally derived diffraction profiles," Nucl. Instrum. Methods Phys. Res., Sect. A 383(2-3), 610-618 (1996). 15. B. Ghammraoui, V. Rebuffel, J. Tabary, C. Paulus, L. Verger, and P. Duvauchelle, "Effect of grain size on stability of X-ray diffraction patterns used for threat detection," Nucl. Instrum. Methods Phys. Res., Sect. A 683, 1-7 (2012).

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Section: Introductionmentioning

confidence: 99%

Energy-dispersive X-ray diffraction using an annular beam

Dicken¹,

Evans²,

Rogers³

et al. 2015

Opt. Express

View full text Add to dashboard Cite

show abstract

“…In addition, the method is open to further exploitation, for example, using total scattering to obtain characteristic signals from amorphous/semi-crystalline materials (e.g. for medical and security applications [33,34]) and ultimately pair-distribution analysis opening up the potential to image small nanocrystalline and amorphous materials (invisible to standard XRD techniques) allowing identification without a priori knowledge.…”

Section: Discussionmentioning

confidence: 99%

Dark-field hyperspectral X-ray imaging

et al. 2014

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In recent times, there has been a drive to develop nondestructive X-ray imaging techniques that provide chemical or physical insight. To date, these methods have generally been limited; either requiring raster scanning of pencil beams, using narrow bandwidth radiation and/or limited to small samples. We have developed a novel full-field radiographic imaging technique that enables the entire physiochemical state of an object to be imaged in a single snapshot. The method is sensitive to emitted and scattered radiation, using a spectral imaging detector and polychromatic hard X-radiation, making it particularly useful for studying large dense samples for materials science and engineering applications. The method and its extension to three-dimensional imaging is validated with a series of test objects and demonstrated to directly image the crystallographic preferred orientation and formed precipitates across an aluminium alloy friction stir weld section.

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“…A diffraction pattern is a measurement of the intensity of scattered X-rays as a function of momentum transfer (1) where χ is the momentum transferred to the photon causing it to deviate through an angle θ and λ is the wavelength of the beam 9 . A range of momentum transfer values can be achieved either by using a mono-energetic beam and varying the scatter angle (referred to as angle-dispersive XRD) or by keeping the scatter angle fixed and exploiting the information from the different energy components present in an X-ray beam from a conventional source (referred to as energy dispersive XRD), as in the present study 10 . In the case of breast cancer, it has been shown that XRD allows differentiation between benign and malignant lesions, as well as cancer staging 4 5 10-13 .…”

Section: Introductionmentioning

confidence: 99%

Energy dispersive X-ray diffraction computed tomography of breast-simulating phantoms and a tissue sample

Alkhateeb

Abdel-Kader

Bradley

et al. 2013

Medical Imaging 2013: Physics of Medical Imaging

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Breast lesions and normal tissue have different characteristics of density and molecular arrangement that affect their diffraction patterns. X-ray diffraction can be used to determine the spatial structure of such tissues at the atomic and molecular level. Energy Dispersive X-Ray Diffraction Computed Tomography (EDXRDCT) can be used to produce 2-dimensional images of cross sections of the samples. The purpose of this work is to use an EDXRDCT system to find the limiting visibility for details that simulate breast lesions. Results are presented for EDXRDCT images of samples of different materials simulating breast tissue contrast and shapes. For simple circular details, the contrast between details and background in the images was measured with the goal of simulating the contrast between real breast tissue components. The limiting visible diameter was measured as a function of detail diameter for different combinations of scanning and geometrical parameters. Images of more complex test objects were assessed in terms of both contrast and accuracy of shape reproduction, evaluating the feasibility of using shape analysis as an additional parameter for lesion identification. The optimum combination of parameters are intended to be applied to the scanning of waxed breast tissue blocks.

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Characterization of breast tissue using energy-dispersive X-ray diffraction computed tomography

Cited by 55 publications

References 33 publications

Energy-dispersive X-ray diffraction using an annular beam

Energy-dispersive X-ray diffraction using an annular beam

Dark-field hyperspectral X-ray imaging

Energy dispersive X-ray diffraction computed tomography of breast-simulating phantoms and a tissue sample

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