Characterization of calcified deposits on contraceptive intrauterine devices

Patai, K; Berényi, M; Sipos, Miklós; Noszál, Béla

doi:10.1016/s0010-7824(98)00114-0

Cited by 28 publications

(12 citation statements)

References 4 publications

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“…Might it be that after some years, a thin coating of some salts could inhibit the antibacterial effect of copper? A similar explanation was suggested by Patai et al (10).…”

Section: Discussionsupporting

confidence: 82%

Prolonged use of intrauterine contraceptive device as a risk factor for tubo‐ovarian abscess

Charonis

Larsson

2009

Acta Obstet Gynecol Scand

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“…Might it be that after some years, a thin coating of some salts could inhibit the antibacterial effect of copper? A similar explanation was suggested by Patai et al (10).…”

Section: Discussionsupporting

confidence: 82%

Prolonged use of intrauterine contraceptive device as a risk factor for tubo‐ovarian abscess

Charonis

Larsson

2009

Acta Obstet Gynecol Scand

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“…There are scarcely any data in the literature on corrosion deposit formation of IUDs in relation to possible bacterial infection. It has been suggested that the formation of calcifi ed deposits and incrustments on the device, due to a gradual corrosion process, may have a clinical signifi cance, especially if bacteria are settled on them [26][27][28] , a suggestion that would be expected to result in an association between PID and long duration of IUD use, which the present study could not confi rm.…”

Section: Discussionmentioning

confidence: 57%

The Impact of Age and Intrauterine Contraception on the Clinical Course of Pelvic Inflammatory Disease

Viberga

Odlind

Berglund

2006

Gynecol Obstet Invest

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Background: The aim of the study was to investigate the clinical course of pelvic inflammatory disease (PID) and factors that could predict failed conservative treatment of PID. Additionally, the study aimed to examine the role of age and intrauterine device (IUD) use on the severity of PID. Method: Fifty-one women admitted to hospital with the diagnosis of acute PID were recruited. Of those, 17 patients were subsequently operated because of failed conservative treatment. All women underwent careful examination and completed a questionnaire at admission. Their clinical course was followed and the clinician responsible for the patient completed forms at admission and at discharge. Two groups were established retrospectively, those who were treated conservatively and those who underwent surgery. The outcome results were analyzed with regard to IUD use, duration of IUD use (≧5 or <5 years), and with regard to age below or above 35 years. All data were analyzed using the statistical package SAS. A p value <0.05 was considered significant. Results: Women who subsequently underwent surgical treatment were significantly older and significantly more frequently, current IUD users. There was no significant difference with regard to other socio-demographic characteristics. Women who subsequently underwent surgery had significantly more frequent complaints of severe abdominal pain, elevated body temperature, symptoms of peritoneal irritation, and appearance of adnexal mass. No differences were found between groups with regard to anaerobic microbiological findings, nor with regard to the finding of Actinomyces. IUD use and age ≧35 were found to be highly significant risk factors for surgery in patients with PID. Conclusion: Age over 35 years and IUD use, independently of each other, were factors strongly associated with an increased risk of surgery for PID as a result of failed conservative treatment.

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“…54 Finally, the corrosion products, such as Cu 2 O, Cu(OH) 2 , and CaCO 3 , are deposited on the surface of the bulk copper; such hard, calcified deposits as CaCO 3 will aggravate the damage of the endometrium. 55,56 Compared with the corroded bulk copper, the surface of the corroded nano-Cu/LDPE composite is much smoother, much softer, and much cleaner. 17 Therefore, the damage caused by the implanted nano-Cu/LDPE composite is much less than that caused by implanted bulk copper.…”

mentioning

confidence: 99%

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Hu¹,

Wang²,

Rao³

et al. 2014

IJN

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A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group ( P <0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group ( P <0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment.

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Characterization of calcified deposits on contraceptive intrauterine devices

Cited by 28 publications

References 4 publications

Prolonged use of intrauterine contraceptive device as a risk factor for tubo‐ovarian abscess

Prolonged use of intrauterine contraceptive device as a risk factor for tubo‐ovarian abscess

The Impact of Age and Intrauterine Contraception on the Clinical Course of Pelvic Inflammatory Disease

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

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