Characterization of Capsaicin-Loaded Nanoemulsions Stabilized with Alginate and Chitosan by Self-assembly

Choi, Ae Jin; Kim, Chul Jin; Cho, Yong Jin; Hwang, Jae Kwan; Kim, Chong Tai

doi:10.1007/s11947-011-0568-9

Cited by 116 publications

(69 citation statements)

References 12 publications

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“…In the development of biohybrid emulsions, it is important to analyze the rheology properties and, consequently, the delivery kinetics of the compound of interest, which would be modified [44]. In general, an increase in viscosity causes a decrease in the rate of drug delivery [45]; it also affects the structural excipients organization in the final pharmaceutical form [46].…”

Section: 1mentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: 1mentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…The MLNE was prepared in two steps with method described elsewhere with a slight modification (9,21). Firstly, AP (250 mg) was dissolved in sufficient amount of ethanol (oil phase) and then mixed with tween 80 in proportion 1:2 of oil phase.…”

Section: Preparation Of Multilayer Ne (Mlne) Of Ap Via Ultrasonicationmentioning

confidence: 99%

“…However, gastric instability of single layer NE was seemed as a major challenge in oral delivery. This could be due to the non-uniform encrusting of biopolymer over NE surface as a result of slight change in processing conditions like temperature, light, and pH (9) thereby increasing the probability of leakage of bioactives (10). Subsequently, layer-by-layer (LbL) coating technology (interaction of oppositively charged polyelectrolyte components) was introduced to produce stable and spherical shaped nano-droplets with uniform size and surface (11).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

et al. 2016

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Andrographolide (AP), a phytoconstituent of Andrographis paniculata is reported as a potent hepatoprotective agent. However, utility of this molecule is restricted due to its low aqueous solubility, gastric instability and hence low bioavailability. It was aimed to formulate and characterize AP-loaded, natural biopolymer stabilized, multilayered nano-hydrocolloid delivery system. Nanoemulsion (NE) was formulated using layer-by-layer (LbL) technology via electrostatic deposition of chitosan over alginate encrusted o/w NE by ultra-sonication. Improved transparency and stability of NE were observed with increasing sonication time. Best stability was obtained after 20 min sonication and particle size of the multilayered NE was measured in the range of 90.8-167.8 nm. Transmission electron microscopy confirmed the progressive layering of nanosized NE. Higher magnitude of zeta potential (i.e., 22.9 to 31.01 mV) confirmed higher stability and coating of alginate layer over NE surface for the period of 3 months. NE showed strategic release pattern when assessed in vitro in various simulated biological fluids of GIT in timed pattern. Multilayered NE showed significant modulation in liver function test (ALT, ALP, AST, TBIL, DBIL, and liver glycogen) and serum cytokines (TNF-α, IL-6, IL-10, and IL-β) when assessed in vivo in galactosamine-lipopolysaccharide intoxicated mice. In conclusion, the andrographolide engrained multi-layered NE enhanced the solubility, stability and henceforth assured the increased availability in simulated biological fluids. The in vivo study exhibited the significantly improved hepatoprotection by andrographolide when delivered in stable multi-layered NE carrier systems.

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“…6 Currently, there are more than 100 compounds identified in OC, such as acids, esters, alcohols, aldehydes, ketones, and carotenoid pigments, as well as capsaicin analogs. 7 It is assumed that some of those components may exert beneficial effects on health in cooperation with each other; however, the application of OC is limited by some drawbacks, such as low solubility and poor bioavailability, 8 thus, biotechnologies have been considered to increase bioavailability of OC.…”

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confidence: 99%

Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

Kim¹,

Lee²,

Jung³

et al. 2014

IJN

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Purpose This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor ( PPAR )-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR - α , palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR - α , palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehydrogenase in white adipose tissue.

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Characterization of Capsaicin-Loaded Nanoemulsions Stabilized with Alginate and Chitosan by Self-assembly

Cited by 116 publications

References 12 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

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