Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

Mishra, Nidhi; Yadav, Kuldeep; Kumar, Vineet; Yadav, Narayan Prasad

doi:10.1208/s12249-016-0512-4

Cited by 42 publications

(10 citation statements)

References 31 publications

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“…The mean charge value on the particles prepared in our study was recorded as -24.43 ± 0.49 mV which is somewhat higher that recorded by Abbas et al, 2015, i.e., -17.2 ± 0.35 mV [22]. Similar results were recorded by Mishra et al [33] and Langella et al [35] with the zeta potential values of 22.9 to 31.01 mV.…”

Section: Discussionsupporting

confidence: 84%

“…The mean diameter of nanocapsules was recorded 160.57 ± 1.06 nm which was in accordance with [18] in which the mean diameter of nanocapsule was 159.85 ± 0.92 nm. Likewise, Mishra et al [33] prepared stable multilayered nanoemulsion using layer-by-layer technology, and particle size were in range of 90.8 to 167.8 nm. Many studies found that stability of encapsulated compound against oxidation was improved in multilayer nanoemulsions [34].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of oral bioavailability of nanocapsules loaded-curcumin in-vivo

Ananda¹,

Tariq²,

Rafiq³

et al. 2021

World J. Adv. Res. Rev.

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Curcumin, a hydrophobic polyphenol found in rhizome of turmeric (curcuma longa) is one of the generally used spice in Asian countries. It has been found through studies that it has numerous health promoting properties and is proved to have curative properties as it possesses antioxidant and anti-inflammatory properties. Due to low oral bioavailability, decreased solubility, quick metabolism and removal from body, it is challenging to achieve maximum benefits from it. This study was aimed to enhance curcumin oral bioavailability by making use of nanoencapsulation technique. Biodegradable nanocapsules were prepared by consecutive addition of food grade polyelectrolytes including OSA-modified starch (PGU), as an emulsifier, chitosan and sodium-carboxymethylcellulose by ultrasonication technique using primary nanoemulsion as template. Results showed that the mean droplet diameter of nanocapsules was 160.57 ± 1.06 nm, the average PDI was 0.14 ± 0.01 and average charge was recorded as -24.43 ± 0.49 mV. Microscopy results showed that the nanostructures were spherical in shape having mean droplet diameter below 200nm. The nanocapsules assessment as a carrier in enhancing the in vivo oral bioavailability of curcumin was made; however, further studies and better tools are needed to clearly know the potential of developed nanosystem.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Assessment of oral bioavailability of nanocapsules loaded-curcumin in-vivo

Ananda¹,

Tariq²,

Rafiq³

et al. 2021

World J. Adv. Res. Rev.

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“…It is known as king of bitter due to the very bitter taste of all part of the plant and in Indonesia its name is sambiloto. In pharmacological research, it shows antidiabetic [1], cytotoxic effect [2], antimicrobial activity [3], anti-inflammatory [4], anti-hyperglycemia [5], antiatherosclerosis [6], antimalaria [7], hepatoprotective [8], and anticancer activity [9]; in vitro and in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

A Simple Liquid-Liquid Fractionation (LLF) Method for Isolating Deoxyandrographolide dan Andrographolide from Herbs of Andrographis paniculata (Burm., F) Ness and Its Cytotoxic Activity on 3T3-L1 Preadipocyte Cells

et al. 2020

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The main bitter constituents of sambiloto (Androgaphis paniculata (Burm., F) Ness) are diterpene lactones, namely andrographolide and deoxyandrographolide which have been reported to have antidiabetic, cytotoxic, antiatherosclerosis, anti-inflammatory, and antimicrobial activity. There are many studies that performed the isolation of deoxyandrographolide and andrographolide from A. paniculata herbs, but most of them included several steps that make them not efficient. This research was conducted to do an isolation of deoxyandrographolide and andrographolide through liquid-liquid fractionation (LLF) due to its simplicity, low cost, and time efficient. The extraction of deoxyandrographolide and andrographolide from the herbs was carried out using chloroform as the solvent by using Soxhlet apparatus, and LLF was performed to isolate the compounds. The identities of the compounds were confirmed by TLC scanner compared to its standard references. Hence, these present methods were successfully isolated and determined deoxyandrographolide and andrographolide of A. paniculata. The compounds were also showed relatively moderate cytotoxicity on 3T3-L1 cell lines using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay, with LC50 of deoxyandrographolide and andrographolide; 29.3173 µg/mL and 37.7011 µg/mL, respectively.

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“…Andrographolide (ADG) is one of the main active components isolated from the Chinese herb Andrographis paniculata . ADG has many pharmacological actions, including anti‐inflammatory, anti‐infection, anticancer, anti‐hyperglycemia, anti‐angiogenesis, hepato‐protection, antifertility, and anti‐HIV effects. However, its high lipophilicity (log P = 2.63), low aqueous solubility (74 μg mL −1 ), and poor stability seriously limit its application .…”

Section: Introductionmentioning

confidence: 99%

Andrographolide solid dispersions formulated by Soluplus to enhance interface wetting, dissolution, and absorption

Song¹,

Wang

Lu³

et al. 2019

J of Applied Polymer Sci

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Andrographolide (ADG) had profound functions as drug health‐care product. To improve ADG application in medical care, solid dispersion technique was introduced. Initially, several polymers were chosen to prepare ADG solid dispersion using hot‐melt extrusion. Working mechanisms of ADG solid dispersion, which include molecular docking and wetting property, were studied. The strongest molecular binding energy of ADG with Soluplus contributed to carrier‐controlled mechanism, leading to its highest drug dissolution. Soluplus as solid dispersion excipient could significantly improve drug absorption. In addition, ADG solid dispersions formulated by Soluplus were prepared and studied, and the ratios of drug to polymer were 1:5, 1:7, 1:9, and 1:12, respectively. It demonstrated that hydrogen bond interactions were formed between ADG and Soluplus based on infrared (IR) spectroscopy analysis. The characteristic peaks of crystal state of ADG at 11.97°, 14.95°, 15.86°, and 9.78° disappeared in ADG solid dispersion, demonstrating that excipient was efficient in transforming drug crystal state to amorphous phase by interacting with ADG. ADG‐Soluplus solid dispersion of 1:7 turned out to be the best with maximum cumulative release amount of more than 80%, whereas other ADG solid dispersions were in the range of 60–70%. The cumulative release amount of pure ADG was below 20%. Comparing with the oral administration of pure ADG, we found that the mean Cmax and AUC values of ADG for ADG‐Soluplus solid dispersion were approximately increased 1.96‐ to 2.53‐fold. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48354.

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Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

Cited by 42 publications

References 31 publications

Assessment of oral bioavailability of nanocapsules loaded-curcumin in-vivo

Assessment of oral bioavailability of nanocapsules loaded-curcumin in-vivo

A Simple Liquid-Liquid Fractionation (LLF) Method for Isolating Deoxyandrographolide dan Andrographolide from Herbs of Andrographis paniculata (Burm., F) Ness and Its Cytotoxic Activity on 3T3-L1 Preadipocyte Cells

Andrographolide solid dispersions formulated by Soluplus to enhance interface wetting, dissolution, and absorption

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