Characterization of cDNAs encoding isoforms of hamster 3 beta-hydroxysteroid dehydrogenase/delta 5--&gt;4 isomerase

Rogerson, Fraser M.; Courtemanche, Jean; Fleury, Alain; Head, Judith R.; Lehoux, Jean‐Guy; Mason, J. Ian

doi:10.1677/jme.0.0200099

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…1997 ; HVU7746, 32%), the UDP‐galactose 4‐epimerase ( Adams et al . 1988 ; P13226, 26%) of yeast, and the 3‐β‐hydroxysteroid dehydrogenase of hamster ( Rogerson et al . 1995 ; HAHMSD3B, 19%).…”

Section: Resultsmentioning

confidence: 99%

The BANYULS gene encodes a DFR‐like protein and is a marker of early seed coat development

Devic¹,

Guilleminot²,

Debeaujon³

et al. 1999

The Plant Journal

221

213

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Summary Mutations in the BANYULS (BAN) gene lead to precocious accumulation of anthocyanins in immature seed coat in Arabidopsis. The ban–1 allele has been isolated from a collection of T‐DNA transformants and found to be tagged by the integrative molecule. The sequencing of wild‐type and two independent mutant alleles confirmed the identity of the gene. Analysis of the full‐length cDNA sequence revealed an open reading frame encoding a 342 amino acid protein which shared strong similarities with DFR and other enzymes of the phenylpropanoid biosynthesis pathway. BAN expression was restricted to the endothelium of immature seeds at the pre‐globular to early globular stages of development as predicted from the maternal inheritance of the phenotype, and therefore represents a marker for early differentiation and development of the seed coat. BAN is probably involved in a metabolic channelling between the production of anthocyanins and pro‐anthocyanidins in the seed coat.

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Section: Resultsmentioning

confidence: 99%

The BANYULS gene encodes a DFR‐like protein and is a marker of early seed coat development

Devic¹,

Guilleminot²,

Debeaujon³

et al. 1999

The Plant Journal

221

213

View full text Add to dashboard Cite

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“…This finding suggests that the non-endocrine tissues of Japanese eel potentially express the P450scc and P450c17 gene, however, the transcript abundance is low and below the detectable level of conventional RT-PCR as employed in this study. Multiple forms of 3β-HSD and its expression in a variety of tissues have been demonstrated in mammals, especially in rodents [35,36]. Therefore, the wide tissue-distribution of the 3β-HSD transcript does not appear to be unique in Japanese eel and 3β-HSD may be involved in reproductive physiology through the regulation of local and/or circulating steroid hormone levels in teleosts, as they are in mammals.…”

Section: Discussionmentioning

confidence: 99%

Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): Tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development

Kazeto

Ijiri

Adachi

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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“…A study on the regulation of adrenal steroidogenic enzymes suggested that the hamster could be a good model for studying human steroidogenesis. With this in mind, three isoenzymes of 3␤-HSD were characterized in the hamster (96,97). The type I isoenzyme was isolated from an adrenal cDNA library and was identified as being a low K m 3␤-HSD (K m : PREG, 5.5 m; DHEA, 2.4 m).…”

Section: The Hamster 3␤-hsd Gene Familymentioning

confidence: 99%

Molecular Biology of the 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Gene Family

et al. 2005

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The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) isoenzymes are responsible for the oxidation and isomerization of Delta(5)-3beta-hydroxysteroid precursors into Delta(4)-ketosteroids, thus catalyzing an essential step in the formation of all classes of active steroid hormones. In humans, expression of the type I isoenzyme accounts for the 3beta-HSD activity found in placenta and peripheral tissues, whereas the type II 3beta-HSD isoenzyme is predominantly expressed in the adrenal gland, ovary, and testis, and its deficiency is responsible for a rare form of congenital adrenal hyperplasia. Phylogeny analyses of the 3beta-HSD gene family strongly suggest that the need for different 3beta-HSD genes occurred very late in mammals, with subsequent evolution in a similar manner in other lineages. Therefore, to a large extent, the 3beta-HSD gene family should have evolved to facilitate differential patterns of tissue- and cell-specific expression and regulation involving multiple signal transduction pathways, which are activated by several growth factors, steroids, and cytokines. Recent studies indicate that HSD3B2 gene regulation involves the orphan nuclear receptors steroidogenic factor-1 and dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome gene 1 (DAX-1). Other findings suggest a potential regulatory role for STAT5 and STAT6 in transcriptional activation of HSD3B2 promoter. It was shown that epidermal growth factor (EGF) requires intact STAT5; on the other hand IL-4 induces HSD3B1 gene expression, along with IL-13, through STAT 6 activation. However, evidence suggests that multiple signal transduction pathways are involved in IL-4 mediated HSD3B1 gene expression. Indeed, a better understanding of the transcriptional factors responsible for the fine control of 3beta-HSD gene expression may provide insight into mechanisms involved in the functional cooperation between STATs and nuclear receptors as well as their potential interaction with other signaling transduction pathways such as GATA proteins. Finally, the elucidation of the molecular basis of 3beta-HSD deficiency has highlighted the fact that mutations in the HSD3B2 gene can result in a wide spectrum of molecular repercussions, which are associated with the different phenotypic manifestations of classical 3beta-HSD deficiency and also provide valuable information concerning the structure-function relationships of the 3beta-HSD superfamily. Furthermore, several recent studies using type I and type II purified enzymes have elegantly further characterized structure-function relationships responsible for kinetic differences and coenzyme specificity.

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Characterization of cDNAs encoding isoforms of hamster 3 beta-hydroxysteroid dehydrogenase/delta 5-->4 isomerase

Cited by 11 publications

References 28 publications

The BANYULS gene encodes a DFR‐like protein and is a marker of early seed coat development

The BANYULS gene encodes a DFR‐like protein and is a marker of early seed coat development

Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): Tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development

Molecular Biology of the 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Gene Family

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