Characterization of Chlorhexidine-Loaded Calcium-Hydroxide Microparticles as a Potential Dental Pulp-Capping Material

Priyadarshini, Balasankar Meera; Selvan, Subramanian Tamil; Narayanan, Karthikeyan; Fawzy, A.

doi:10.3390/bioengineering4030059

Cited by 24 publications

(15 citation statements)

References 58 publications

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“…From the calibration graph (Figure 4), the concentration of free CHX (µg/mL) was determined using the obtained linear regression equations ( R 2 > 0.99). The EE and LC were calculated using Equations (1) and (2) [30]. Based on the LC and EE, Equations (3) and (4) were created to calculate the unknown percentage concentration by weight of CHX (CHX wt %) and mass of CHX (mCHX) in the coating solution: EE (%) =mCHXa − mCHXfmCHXa×100 LC (%) =mCHXemCHX@MSN×100 CHX wt%=mCHX@MSN × LC(mCHX@MSN+mPDMS) mCHX=CHX wt% ×…”

Section: Methodsmentioning

confidence: 99%

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Mai

Kim

Hyun

et al. 2019

JCM

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Chlorhexidine (CHX) has been incorporated into the composition of polymethyl methacrylate (PMMA) dental restorations to enhance their antimicrobial performance. However, the controlled delivery of CHX remains a challenge. Although previous findings with pure silica or polymer coatings demonstrated the resistance to bacterial adhesion, they did not provide antibacterial activity beyond the coated surface. Polydimethylsiloxane (PDMS) and mesoporous silica nanoparticles (MSNs) are widely used in biomedical science as a transfer medium in drug delivery systems. Here, the MSNs are used to encapsulate CHX, and the combination is added to PDMS. A thin coating film is formed on the PMMA, using oxygen plasma and thermal treatment. The liquid chromatography analysis shows that the coating film has high encapsulation efficiency and loading capacity, with a slow and stable release rate of CHX. The cytotoxicity tests also show that the coating does not affect the proinflammatory cytokines, cellular mitotic activity, or apoptotic cell death. The ability of the coating to release CHX indicates that the coating may even be effective against bacteria that are not directly in contact with the surface. This antibacterial protective film is expected to be a novel method to inhibit bacterial activity distal to the coated surfaces of PMMA restorations.

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Section: Methodsmentioning

confidence: 99%

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Mai

Kim

Hyun

et al. 2019

JCM

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“…It has been known for some years that the combination of two of these antiseptics (i.e., 2% chlorhexidine in alcohol solution) is to be considered the best choice for skin disinfection before and after the placement of a venous access. New formulations have been developed subsequently [15].…”

Section: Introductionmentioning

confidence: 99%

Chlorhexidine Gel Use in the Oral District: A Systematic Review

Fiorillo

2019

Gels

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Chlorhexidine compounds and their different formulations have been investigated several times, especially in the dentistry field. Chlorhexidine application for mouth rinsing immediately underwent oral contraindications, linked to the possibility of causing pigmentation to the teeth or relating to possible cytotoxic events after oral surgery. The positive effects, however, are considerable and its topical antiseptic action has been widely demonstrated by in vitro and clinical research. That’s the reason for its large application in different fields of dentistry. The aim of this study is to collect all the literature regarding the use of chlorhexidine gel in dentistry and all the numerous applications. The initial search on search engines obtained 232 results; then, following the application of the inclusion criteria there were 24 selected articles. The chlorhexidine gel appliance in the dental daily practice is direct to oral surgery, conservative endodontics, prevention and prophylaxis. The use of chlorhexidine has shown some positive effects, also in the case of systemic diseases prevention. Surely, this topical medicine used both professionally and prescribed for home use, can be considered a great help for the prevention of several oral pathologies with systemic implications too.

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“…While infrared spectra of CHX showed the presence of fingerprint of amine (CH and NH) band at ≈ 2,947 and 1,650 cm −1 as well as Raman bands of NH at 1450–1350, 1,232 cm‐1. This finding is indicative of inclusive of CHX within the material surface (Priyadarshini, Selvan, Narayanan, & Fawzy, 2017).…”

Section: Discussionmentioning

confidence: 93%

Morphological and chemical analysis of surface interaction of irrigant‐endosequence root repair material

2020

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This study aimed to evaluate the characterization of chemical interaction of root canal irrigants on the surface of EndoSequence root repair materials using spectroscopy analysis. Round discs of putty and paste were obtained and immersed in saline, sodium hypochlorite (NaOCl), or chlorhexidine. On the surface of chlorhexidine treated putty, diffuse red pigmentation was detected by Raman analysis and diffuse black pigmentation having unusual needle-like shaped crystals was detected by scanning electron microscopy. This pigmentation formed from nitrogen-rich compounds detected by Raman, infrared spectroscopy, and X-ray diffraction analysis. Mineral/ amide ratios were increased by NaOCl and significantly decreased by chlorhexidine. Carbonate/phosphate ratios showed no significant changes by NaOCl, while a significant decrease by chlorhexidine. A full half of maximum width Raman of the phosphate band was significantly increased by NaOCl, while decreased by chlorhexidine. In conclusion; nitrogen-rich compounds produced by chlorhexidine altered the surface morphology of the putty without crystallinity reduction. However, NaOCl reduced the organic fillers that affected its binding to phosphate ions. This reaction affects the chemical properties and perfection of root repair material. The clinicians should be aware of different irrigants to be used after repairing the perforation.

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Characterization of Chlorhexidine-Loaded Calcium-Hydroxide Microparticles as a Potential Dental Pulp-Capping Material

Cited by 24 publications

References 58 publications

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Chlorhexidine Gel Use in the Oral District: A Systematic Review

Morphological and chemical analysis of surface interaction of irrigant‐endosequence root repair material

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