Characterization of chronic obstructive pulmonary disease in dairy farmers

Soumagne, Thibaud; Degano, Bruno; Guillien, Alicia; Annesi‐Maesano, Isabella; Andujar, Pascal; Hüe, Sophie; Adotévi, Olivier; Jouneau, S.; Botebol, M.; Laplante, Jean‐Jacques; Roche, Nicolás; Dalphin, Jean‐Charles

doi:10.1016/j.envres.2020.109847

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…For instance, CHCs with an industrial predominant activity such as Sabiñánigo and Monzón, Calatayud, the River Ebro Valley and Andorra, Utrillas and Caspe surroundings denote higher rates of prevalence. The importance of socioeconomic and labor factors is well known, particularly in rural areas, which can be underestimated in population studies (Soumagne et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Spatial Patterns in the Association between the Prevalence of Asthma and Chronic Obstructive Pulmonary Disease: Socioeconomic and Climate Indicators in a Mediterranean Region

Bentué

Mimbrero

González

et al. 2021

Preprint

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The World Health Organization endorses the study of diseases from the perspective of the Determinants of Health (DH). DH are known as the circumstances in which people are born and raised, the environment in which they grow up and age and their lifestyle. The aim of this study is to analyze the spatial behavior of the prevalence of chronic obstructive pulmonary disease (COPD) and asthma in 2017 in Aragon, a Mediterranean region in Spain, using a DH approach. The methodological process entailed building a spatial database collating sociodemographic and climate indicators, and then evaluating the spatial variability of the relationships between DH indicators and disease prevalence by combining the Principal Component Analysis (PCA), Geographically Weighted Regression (GWR) models and cartographic design techniques. GWR evidences both global and spatially varying relationships, although each prevalence behaves differently. Asthma seems closely tied to local climate patterns whereas COPD is largely influenced by the built environment. Consequently, the socioeconomic and climatic contrasts characterizing the study area translate into several DH scenarios leading to situations vulnerable to the prevalence of asthma and COPD. This differential DH behavior detected by local regression models is relevant to guiding and refining public health decision-making.

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Section: Discussionmentioning

confidence: 99%

Spatial Patterns in the Association between the Prevalence of Asthma and Chronic Obstructive Pulmonary Disease: Socioeconomic and Climate Indicators in a Mediterranean Region

Bentué

Mimbrero

González

et al. 2021

Preprint

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“…[68][69][70] Recent studies in farmers have associated lifelong exposure to organic dust with the occurrence of COPD. 71,72 Exposure to other types of organic dust in the textile sector 73 or in paper mills 74 has been associated with COPD or accelerated lung function decline.…”

Section: Cohort Studiesmentioning

confidence: 99%

Occupational COPD—The most under‐recognized occupational lung disease?

Murgia

Gambelunghe

2022

Respirology

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Chronic obstructive pulmonary disease (COPD) is caused by exposure to noxious particles and gases. Smoking is the main risk factor, but other factors are also associated with COPD. Occupational exposure to vapours, gases, dusts and fumes contributes to the development and progression of COPD, accounting for a population attributable fraction of 14%. Workplace pollutants, in particular inorganic dust, can initiate airway damage and inflammation, which are the hallmarks of COPD pathogenesis. Occupational COPD is still underdiagnosed, mainly due to the challenges of assessing the occupational component of the disease in clinical settings, especially if other risk factors are present. There is a need for specific education and training for clinicians, and research with a focus on evaluating the role of occupational exposure in causing COPD. Early diagnosis and identification of occupational causes is very important to prevent further decline in lung function and to reduce the health and socio‐economic burden of COPD. Establishing details of the occupational history by general practitioners or respiratory physicians could help to define the occupational burden of COPD for individual patients, providing the first useful interventions (smoking cessation, best therapeutic management, etc.). Once patients are diagnosed with occupational COPD, there is a wide international variation in access to specialist occupational medicine and public health services, along with limitations in workplace and income support. Therefore, a strong collaboration between primary care physicians, respiratory physicians and occupational medicine specialists is desirable to help manage COPD patients' health and social issues.

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“…Development of COPD following the chronic inhalation of environmental dusts seems to be mainly driven by an inflammatory reaction that occurs in a subset of exposed subjects (2,9,24). COPD in these patients has been associated with some Th2 phenotype markers and is considered to depend on individuals' susceptibility rather than on the magnitude and/or the characteristics of exposure (30,38).…”

Section: Introductionmentioning

confidence: 99%

Never-smokers with occupational COPD have better exercise capacities and ventilatory efficiency than matched smokers with COPD

Soumagne

Guillien

Roche

et al. 2020

Journal of Applied Physiology

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Background. COPD in never-smokers exposed to organic dusts is still poorly characterized. Therapeutic strategies in COPD are only evaluated in smoking-related COPD. To understand how never-smokers with COPD behave during exercise is an important prerequisite for optimal management. Objectives. To compare physiological parameters measured at exercise between never-smokers exposed to organic dusts with COPD and patients with smoking-related COPD matched for age, sex and severity of airway obstruction. Healthy controls were also studied. Methods. Dyspnea (Borg scale), exercise tolerance and ventilatory constraints were assessed during incremental cycle cardiopulmonary exercise testing in COPD patients at mild-to-moderate stages (22 exposed to organic dusts, postbronchodilator FEV1/FVC z-score: -2.44±0.72 and FEV1z-score: -1.45±0.78; 22 with smoking-related COPD, FEV1/FVC z-score: -2.45±0.61; FEV1z-score: -1.43±0.69) and 44 healthy controls (including 22 never-smokers). Results. Despite the occurrence of similar significant dynamic hyperinflation, never-smokers COPD patients exposed to organic dusts had lower dyspnea ratings than those with smoking-related COPD. They also had higher peak oxygen consumption, peak power output and better ventilatory efficiency than smoking-related COPD, all these parameters being similar controls. Differences in exercise capacity between the two groups of COPD were mainly driven by better ventilatory efficiency stemming from preserved diffusing capacity.Conclusion Never-smokers exposed to organic dusts with mild-to-moderate COPD have better exercise capacities, better ventilatory efficiency and better diffusion capacity than matched patients with smoking-related COPD.

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Characterization of chronic obstructive pulmonary disease in dairy farmers

Cited by 8 publications

References 50 publications

Spatial Patterns in the Association between the Prevalence of Asthma and Chronic Obstructive Pulmonary Disease: Socioeconomic and Climate Indicators in a Mediterranean Region

Spatial Patterns in the Association between the Prevalence of Asthma and Chronic Obstructive Pulmonary Disease: Socioeconomic and Climate Indicators in a Mediterranean Region

Occupational COPD—The most under‐recognized occupational lung disease?

Never-smokers with occupational COPD have better exercise capacities and ventilatory efficiency than matched smokers with COPD

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