2012
DOI: 10.1016/j.jpba.2012.04.017
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Characterization of currently marketed heparin products: Adverse event relevant bioassays

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Cited by 8 publications
(4 citation statements)
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“…[11][12][13][14] In this study, to further develop and rene this approach, the 2D-1 H- 13 C-HSQC experiment was applied to a larger set of samples obtained from multiple sources that had been thoroughly characterized by a number of orthogonal techniques. 4,7,15,16 The HSQC experiment detects the effect of the carbon nucleus connected to a proton indirectly via the proton magnetization. The instrument response is dependent on experimental parameters and the magnitude of the one-bond scalar-coupling between 1 H- 13 C pairs ( 1 J CH ), the proton T 1 and T 2 relaxation times, J HH evolution during the polarization transfer period and offset effects on the 13 C-nucleus pulses.…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13][14] In this study, to further develop and rene this approach, the 2D-1 H- 13 C-HSQC experiment was applied to a larger set of samples obtained from multiple sources that had been thoroughly characterized by a number of orthogonal techniques. 4,7,15,16 The HSQC experiment detects the effect of the carbon nucleus connected to a proton indirectly via the proton magnetization. The instrument response is dependent on experimental parameters and the magnitude of the one-bond scalar-coupling between 1 H- 13 C pairs ( 1 J CH ), the proton T 1 and T 2 relaxation times, J HH evolution during the polarization transfer period and offset effects on the 13 C-nucleus pulses.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, there were some subtle differences in response between CS3.0, CS3.1 and CS3.2 which could indicate that there may be some specific features that influence the activation of kallikrein. Previously it has been shown that OSCS can activate bradykinin [ 4 , 31 ] and this study under the conditions used the is no bradykinin activity without kallikrein formation. Concentrations of OSCS that generated the same level of kallikrein, also generated the same amount of bradykinin, consistent with prekallikrein activation being the sole mechanism through which OSCS influences bradykinin generation.…”
Section: Discussionmentioning
confidence: 77%
“…On the other hand, DS will probably not be as antigenic as CS in the case of HNK-1 because, as opposed to the latter, which can contain the antigen 3-sulfated GlcA epitope, DS does not present this motif (Table 2). Nonetheless, while not confirming the hypotensive side-effect, there are studies that indicate that oversulfated DS can cause kallikrein activation [236,237].…”
Section: Drawbacksmentioning
confidence: 99%