Characterization of elasticity and hydration of composite hydrogel based on collagen-iota carrageenan as a corneal tissue engineering

Rinawati, M; Triastuti, Juni; Pursetyo, Kustiawan Tri

doi:10.1088/1755-1315/137/1/012042

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…The mold was then dissolved within the solidified hydrogel to generate complex 3D vascular networks without any manual alignment or bonding. Both of the materials are transparent, with optical properties close to that of water (RI = 1.35–1.39 ( Fu et al, 2017 ; Rinawati et al, 2018 )). After being crosslinked chemically, Gelatin had an elastic modulus of ∼0.3–20 kPa ( Zhao et al, 2016 ) and an elongation at break of ∼70% ( Lee et al, 2019 ).…”

Section: Microfluidic Scaffold—materials and Manufacturingmentioning

confidence: 98%

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A Minireview of Microfluidic Scaffold Materials in Tissue Engineering

Tong

Voronov

2022

Front. Mol. Biosci.

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In 2020, nearly 107,000 people in the U.S needed a lifesaving organ transplant, but due to a limited number of donors, only ∼35% of them have actually received it. Thus, successful bio-manufacturing of artificial tissues and organs is central to satisfying the ever-growing demand for transplants. However, despite decades of tremendous investments in regenerative medicine research and development conventional scaffold technologies have failed to yield viable tissues and organs. Luckily, microfluidic scaffolds hold the promise of overcoming the major challenges associated with generating complex 3D cultures: 1) cell death due to poor metabolite distribution/clearing of waste in thick cultures; 2) sacrificial analysis due to inability to sample the culture non-invasively; 3) product variability due to lack of control over the cell action post-seeding, and 4) adoption barriers associated with having to learn a different culturing protocol for each new product. Namely, their active pore networks provide the ability to perform automated fluid and cell manipulations (e.g., seeding, feeding, probing, clearing waste, delivering drugs, etc.) at targeted locations in-situ. However, challenges remain in developing a biomaterial that would have the appropriate characteristics for such scaffolds. Specifically, it should ideally be: 1) biocompatible—to support cell attachment and growth, 2) biodegradable—to give way to newly formed tissue, 3) flexible—to create microfluidic valves, 4) photo-crosslinkable—to manufacture using light-based 3D printing and 5) transparent—for optical microscopy validation. To that end, this minireview summarizes the latest progress of the biomaterial design, and of the corresponding fabrication method development, for making the microfluidic scaffolds.

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Section: Microfluidic Scaffold—materials and Manufacturingmentioning

confidence: 98%

“…Frontiers in Molecular Biosciences | www.frontiersin.org with optical properties close to that of water (RI 1.35-1.39 (Fu et al, 2017;Rinawati et al, 2018)). After being crosslinked chemically, Gelatin had an elastic modulus of ∼0.3-20 kPa (Zhao et al, 2016) and an elongation at break of ∼70% (Lee et al, 2019).…”

Section: Stretchable Flexiblementioning

confidence: 99%

A Minireview of Microfluidic Scaffold Materials in Tissue Engineering

Tong

Voronov

2022

Front. Mol. Biosci.

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“…Corneal tissue engineering requires high mechanical strength and hydration strength. Rinawati et al [49] developed a compound collagen-karae hydrogel with karawa gel, which equilibrate the water content of 87.07%, viscosity of 10.7346 Pa.s, which is closer to corneal tissue characteristics.…”

Section: Organization Engineeringmentioning

confidence: 99%

Progress in Application of Carrageenan Hydrogel in Biomedicine

Zhang

Gao

et al. 2021

J. Photopol. Sci. Technol.

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Carrageenan-based hydrogel, as a kind of natural polymer soft material with a threedimensional network structure, has good biocompatibility, biodegradability and biosafety, and has high water content, structure and performance. The matrix is similar and has received extensive attention from researchers. This article outlines the structure and properties of carrageenan-based hydrogels, and classifies carrageenan-based hydrogels according to their functionality, focusing on self-healing, antibacterial, stimulus-responsive, and conductive carrageenan-based hydrogels. The characteristics and properties of glue and its application progress in drug delivery, wound healing, tissue engineering, and biological intelligent sensing. Finally, the problems and challenges faced by carrageenan-based hydrogels are discussed, and the future of carrageenan-based hydrogels are prospected. Possible development trend.

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