Characterization of epicathechin contents in the <i>Ziziphus spina-christi</i> L. root extracts using LC-MS analyses and their insecticidal potential

Elaloui, Meriem; Haouel-Hamdi, Soumaya; Ghazghazi, Hanene; Nasr, Rania Ben; Bouslih, Emna; Ammari, Youssef; Mediouni, Jouda; Laamouri, Abdelwahed

doi:10.1080/11263504.2020.1779837

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…One new polyphenol, quercetin 3- O -(4- O -trans- p -coumaroyl)- α -L-rhamnopyranosyl-(1⟶2)-[ α -L-rhamnopyranosyl-(1⟶6)]- β -D-galactopyranoside, was reportedly isolated from n-butanol fraction of the leaves [ 172 ]. LC-MS-ESI analysis of the root ethanol extract revealed the presence of epicatechin [ 41 ]. Spectra data from HPLC and UV-visible analysis revealed the presence of catechin, gallic acid, ellagic acid, chlorogenic acid, rutin, isoquercitrin, quercetin, and kaempferol in the methanolic extract of the fruit [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established.

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Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…ZSC leaves are a rich source of phenolic compounds including chlorogenic acids, proanthocyanidins, simple and highly glycosylated flavonoids. Fifty-seven components were tentatively detected and characterized on the basis of reported analytical data from three to four pieces of independent methods including retention time, UV/Vis spectroscopy, high resolution mass spectrometry (HR-MSn), and tandem mass spectrometry (MSn) (Elaloui et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Exploration of the flavonoid content of Ziziphus spina-christi leaf extract and antioxidant activity assay through in vitro and in silico methods

et al. 2023

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The human body naturally has an antioxidant system to counteract free radical reactivity in a sustainable manner, but if the number of free radicals in the body is excessive, additional antioxidants are needed from food intake, namely vitamin C, vitamin E, carotenes and flavonoids. One plant that has the potential as an antioxidant is Ziziphus spina-christi (ZSC) because it contains phenolics and flavonoids. This study aims to determine the flavonoid content both qualitatively and quantitatively and to test the antioxidant activity of ZSC leaf extract using in vitro and in silico attenuation methods. Determination of the total flavonoid content of ZSC leaf extract using a comparison of quercetin. In vitro the antioxidant activity assay of ZSC leaf extract was carried out by measuring the reducing activity of ZSC leaf extract against the radical DPPH using ascorbic acid as a comparison, while the in silico method used QSAR and pharmacophore modelling techniques. The results showed that the total flavonoid content obtained from ZSC leaf extract was 0.2515 ± 0.0013 mg QE/g D.W with an IC50 of 58.9296 ppm. Furthermore, from the in silico method using pharmacophore modeling and QSAR techniques, 8 hit compounds were obtained from the content of ZSC with IC50 QSAR ranging from 6.57 μM to 0.0004 μM, which was thought to be the metabolite that had the most role in its antioxidant activity. This value indicates that ZSC leaf extract has potential as a very strong antioxidant. ZSC leaf extract can be used as an antioxidant candidate in drug and cosmetic preparations through the oral or percutaneous route. It also proves that QSAR and pharmacophore modelling techniques can be used as confirmatory tests for in vitro results in determining the antioxidant activity of natural materials.

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“…So why it was named Chinese jujube or Chinese date. Ziziphus pulps were very famous for their richness in mineral fibers, vitamins, and polyphenols (Elaloui et al, 2020 ; Rashwan et al, 2020 ). Unfortunately, shelf life could not exceed more than 3 months because jujube cannot be stored for a long period under ambient conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Ziziphus pulps were very famous for their richness in mineral fibers, vitamins, and polyphenols (Elaloui et al, 2020;Rashwan et al, 2020).…”

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confidence: 99%

Effect on Ziziphus jujuba Mill. fruit powders embedded on physicochemical properties, biological activities, and rheologic quality of cake

Elaloui

Ammari

Ghazghazi

et al. 2023

Food Science & Nutrition

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This study aimed to improve the effects on the physical, textural, and rheological characteristics of cake supplied with Ziziphus jujuba fruit powder at rates of 0%, 3%, 5%, and 10%. The Physicochemical and antioxidant as well as the antibacterial activity and sensory qualities of Z. jujuba fruits were also investigated. The highest levels reached the values of 245.15 mg GAE/g DW (phenol) and 180.23 mg RE/g DW (flavonoids). Pulp extracts were also subjected to HPLC analysis in order to identify and quantify the sugar composition. This technique allowed us to identify Mahdia as the richest provenance especially in glucose (136.51%) and sucrose (113.28%) contents. The antioxidant activities investigated using DPPH assay decreased slightly from 175 μg/mL (Sfax) to 55 μg/mL (Mahdia). Furthermore, the antibacterial activity indicated that the S. aureus was the most inhibited especially by Sfax powder extracts (from 12 to 20 mm). Our results showed that the incorporation of Z. jujuba powder ameliorated the physicochemical and rheological characteristics (humidity, gluten yield, tenacity, falling time, and configuration) of the dough. Sensory analysis showed that consumer scores were increased with the increasing supplementation powder levels. Highest scores attributed to the cake supplied with 3% jujube powder collected from Mahdia provenance and confirmed that Ziziphus fruit could be advised a part of our diet. These results could validate a novel method to conserve Z. jujuba fruits in order to avoid their soilages for a long period.

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Characterization of epicathechin contents in the Ziziphus spina-christi L. root extracts using LC-MS analyses and their insecticidal potential

Cited by 6 publications

References 20 publications

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Exploration of the flavonoid content of Ziziphus spina-christi leaf extract and antioxidant activity assay through in vitro and in silico methods

Effect on Ziziphus jujuba Mill. fruit powders embedded on physicochemical properties, biological activities, and rheologic quality of cake

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