Characterization of fetal cardiac structure and function detected by echocardiography in women with normal pregnancy and gestational diabetes mellitus

Ren, Yanping; Zhou, Qiongjie; Yan, Yongkun; Chu, Chen; Gui, Yonghao; Li, Xiaotian

doi:10.1002/pd.2717

Cited by 48 publications

(44 citation statements)

References 33 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tissue Doppler was able to detect both systolic and diastolic dysfunction than conventional Doppler in infants of diabetic mothers with hypertrophic cardiomyopathy when compared to the control group. This higher sensitivity of tissue Doppler over the conventional Doppler was previously reported in various studies [20,29,30]. We also found that Tei index was more sensitive than left or right ventricle fractional shortening in detecting impaired cardiac performance.…”

Section: /9supporting

confidence: 71%

Correlation of Cord blood Cardiac Troponin-T to Echocardiographic and Tissue Doppler Variables in Infants of Diabetics Mothers with and without Hypertrophic Cardiomyopathy

Al‐Biltagi¹,

Serag²,

Al-Asy³

et al. 2016

JPNC

View full text Add to dashboard Cite

Objective: The objective was to evaluate the value of cord blood cardiac troponin-T levels and tissue Doppler echocardiography in evaluation of hypertrophic cardiomyopathy in infants of diabetic mothers. Methods:A prospective study involved 60 infants of diabetic mothers and 60 healthy neonates.Cord blood level of cardiac troponin-T was measured and conventional and tissue Doppler echocardiographies were performed for all infants. Results:Hypertrophic cardiomyopathy was present in 19 cases (31.6%) of infants of diabetic mothers. There were significant increase in the cord blood cardiac troponin-T levels (P<0.0001) and more significant systolic and diastolic dysfunction in infants of diabetic mothers than in control group. Infants of diabetic mothers with hypertrophic cardiomyopathy had significant increase in the cord blood cardiac troponin-T levels (P<0.0001) and more significant systolic and diastolic dysfunction than infants of diabetic mothers without hypertrophic cardiomyopathy. There was no significant correlation between infant's birth weight and cord blood cardiac troponin-T levels while there was significant correlation between maternal glycosylated hemoglobin and cord blood levels of cardiac troponin-T. There were significant negative correlation between cord blood levels of cardiac troponin-T and E/A ratio at mitral valve, E'/A' ratio and S wave at mitral annulus, E/A ratio tricuspid valve, E'/A' ratio and S wave at tricuspid annulus. There were positive correlations between cord blood cardiac troponin-T levels with septal/posterior wall, and Tie indices.Conclusion: cardiac troponin-T was a useful marker especially when combined with tissue Doppler echocardiography for evaluation of hypertrophic cardiomyopathy in infants of diabetic mothers. Keywords:

show abstract

Section: /9supporting

confidence: 71%

Correlation of Cord blood Cardiac Troponin-T to Echocardiographic and Tissue Doppler Variables in Infants of Diabetics Mothers with and without Hypertrophic Cardiomyopathy

Al‐Biltagi¹,

Serag²,

Al-Asy³

et al. 2016

JPNC

View full text Add to dashboard Cite

show abstract

“…In the US, up to 18% of all pregnancies are now affected by diabetes (52), and 35% of women are obese (23), a comorbidity that increases health risks (36). Infants born to obese or diabetic mothers are at higher risk of cardiovascular disease at birth (29,51,59) and throughout life (22,54), purportedly through fuel-mediated influences (5,10,24). Current preventative measures focus on glucose control (2).…”

mentioning

confidence: 99%

Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction

Mdaki

Larsen

Wachal

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

161

View full text Add to dashboard Cite

Offspring of diabetic pregnancies are at risk of cardiovascular disease at birth and throughout life, purportedly through fuel-mediated influences on the developing heart. Preventative measures focus on glycemic control, but the contribution of additional offenders, including lipids, is not understood. Cellular bioenergetics can be influenced by both diabetes and hyperlipidemia and play a pivotal role in the pathophysiology of adult cardiovascular disease. This study investigated whether a maternal high-fat diet, independently or additively with diabetes, could impair fuel metabolism, mitochondrial function, and cardiac physiology in the developing offspring's heart. Sprague-Dawley rats fed a control or high-fat diet were administered placebo or streptozotocin to induce diabetes during pregnancy and then delivered offspring from four groups: control, diabetes exposed, diet exposed, and combination exposed. Cardiac function, cellular bioenergetics (mitochondrial stress test, glycolytic stress test, and palmitate oxidation assay), lipid peroxidation, mitochondrial histology, and copy number were determined. Diabetes-exposed offspring had impaired glycolytic and respiratory capacity and a reduced proton leak. High-fat diet-exposed offspring had increased mitochondrial copy number, increased lipid peroxidation, and evidence of mitochondrial dysfunction. Combination-exposed pups were most severely affected and demonstrated cardiac lipid droplet accumulation and diastolic/systolic cardiac dysfunction that mimics that of adult diabetic cardiomyopathy. This study is the first to demonstrate that a maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancies through metabolic stress and serves as a critical step in understanding the role of cellular bioenergetics in developmentally programmed cardiac disease.

show abstract

“…Hypertrophic cardiomyopathy observed in the infant of the diabetic mother is characterized by thickening of the interventricular septum, and to a lesser extent the ventricular free walls (Hornberger, 2006). The presence of this pathology whether is associated with fetal hyperinsulinaemia and general somatic growth in maternal diabetes (Buchanan & Kjos, 1999;Ren et al, 2011). But, the wide variety of cardiac abnormalities suggests a complex pathogenesis.…”

Section: Congenital Cardiopathies and Diabetes Mellitusmentioning

confidence: 99%

“…Experimental studies suggest that hyperglycemia is the major teratogen in diabetic pregnancies, but other diabetes-related factors may also affect fetal outcomes (Aberg at al., 2001;Buchanan & Kjos, 1999;Leonard et al, 1989;Ren et al, 2011). It is a fact that an uncontrolled diabetes mellitus in early gestation is associated with a teratogenic effect, causing primary cardiogenesis defects.…”

Section: Congenital Cardiopathies and Diabetes Mellitusmentioning

confidence: 99%

See 1 more Smart Citation

Congenital Cardiopathies Screening Associated with Diabetes Mellitus Using Maternal Fructosamine Plasma Concentration

Reis¹,

Costa²

2011

Gestational Diabetes

View full text Add to dashboard Cite

Characterization of fetal cardiac structure and function detected by echocardiography in women with normal pregnancy and gestational diabetes mellitus

Abstract: Fetal cardiac wall thickness, cardiac systolic and diastolic functions are affected by GDM independently of glycemic control.

Cited by 48 publications

References 33 publications

Correlation of Cord blood Cardiac Troponin-T to Echocardiographic and Tissue Doppler Variables in Infants of Diabetics Mothers with and without Hypertrophic Cardiomyopathy

Correlation of Cord blood Cardiac Troponin-T to Echocardiographic and Tissue Doppler Variables in Infants of Diabetics Mothers with and without Hypertrophic Cardiomyopathy

Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction

Congenital Cardiopathies Screening Associated with Diabetes Mellitus Using Maternal Fructosamine Plasma Concentration

Contact Info

Product

Resources

About