Characterization of flow intensity in continuous centrifuges for the development of laboratory mimics

Boychyn, M.; Yim, Sung-Sam; Shamlou, P. Ayazi; Bulmer, M.; More, John; Hoare, M.

doi:10.1016/s0009-2509(01)00139-7

Cited by 88 publications

(133 citation statements)

References 13 publications

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“…Simulations of the flow in some industrial process equipment have been developed using CFD and even some researchers [7][8][9] have recently attempted to simulate the flow in centrifuges.…”

Section: Physical Separation In Science and Engineeringmentioning

confidence: 99%

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A Numerical Study of the Impact of Radial Baffles in Solid Bowl Centrifuges Using Computational Fluid Dynamics

Fernández

Nirschl

2010

Physical Separation in Science and Engineering

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Centrifugal separation equipment, such as solid bowl centrifuges, is used to carry out an effective separation of fine particles from industrial fluids. Knowledge of the streams and sedimentation behavior inside solid bowl centrifuges is necessary to determine the geometry and the process parameters that lead to an optimal performance. Regarding a given industrial centrifuge geometry, a grid was built to calculate numerically the multiphase flow of water, air, and particles with a computational fluid dynamics (CFD) software. The effect of internal radial baffles on the multiphase flow was investigated. The results show that the baffles are helpful for the acceleration of the fluid, but they disturb the axial boundary layer, making it irregular, and originate a secondary circulating flow which hinders the sedimentation of small particles.

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“…Simulations of the flow in some industrial process equipment have been developed using CFD and even some researchers [7][8][9] have recently attempted to simulate the flow in centrifuges.…”

Section: Physical Separation In Science and Engineeringmentioning

confidence: 99%

“…As the centrifuge rotates with an angular velocity ω about the Z-axis, the forces on the particles in X and Y direction are given by (6) and (7). The rotational forces F r include the centrifugal force (first term) and the Coriolis force (second term), which arises in the moving reference frame.…”

Section: Mathematical Formulation Of the Particlesmentioning

confidence: 99%

A Numerical Study of the Impact of Radial Baffles in Solid Bowl Centrifuges Using Computational Fluid Dynamics

Fernández

Nirschl

2010

Physical Separation in Science and Engineering

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“…Mannweiler and Hoare (1992) performed a grade efficiency analysis of protein precipitate suspensions derived from clarified mechanically disrupted Saccharomyces cerevisiae and processed through a disc stack centrifuge and concluded that breakage of aggregate occurred in the feed zone and this was demonstrated also for a multichamber bowl centrifuge (Boychyn et al, 2000). These studies required pilot scale quantities of test material but Boychyn et al (2001) subsequently approached the issue using regime analysis and ultra scale-down. Computational fluid dynamics (CFD) was applied to analyze the flow field in the entry region of a multichamber machine which defined in more precise terms the levels and duration of shear.…”

Section: Centrifugationmentioning

confidence: 99%

Micro biochemical engineering to accelerate the design of industrial‐scale downstream processes for biopharmaceutical proteins

Titchener‐Hooker

Dunnill

Hoare

2008

Biotech & Bioengineering

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The article examines how a small set of easily implemented micro biochemical engineering procedures combined with regime analysis and bioprocess models can be used to predict industrial scale performance of biopharmaceutical protein downstream processing. This approach has been worked on in many of our studies of individual operations over the last 10 years and allows preliminary evaluation to be conducted much earlier in the development pathway because of lower costs. It then permits the later large scale trials to be more highly focused. This means that the risk of delays during bioprocess development and of product launch are reduced. Here we draw the outcomes of this research together and illustrate its use in a set of typical operations; cell rupture, centrifugation, filtration, precipitation, expanded bed adsorption, chromatography and for common sources, E. coli, two yeasts and mammalian cells (GS-NSO). The general approach to establishing this method for other operations is summarized and new developments outlined. The technique is placed against the background of the scale-down methods that preceded it and complementary ones that are being examined in parallel. The article concludes with a discussion of the advantages and limitations of the micro biochemical engineering approach versus other methods.

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“…This study uses computational fluid dynamics (CFD) to solve numerically the governing flow equations in the centrifuge. Although CFD has been used to develop models of flow in some industrial devices, only recently researchers have tried to simulate the flow in centrifuges [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Multiphase CFD Simulation of a Solid Bowl Centrifuge

Fernández

Nirschl

2009

Chem Eng & Technol

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This study presents some results from the numerical simulation of the flow in an industrial solid bowl centrifuge used for particle separation in industrial fluid processing. The computational fluid dynamics (CFD) software Fluent was used to simulate this multiphase flow. Simplified two-dimensional and three-dimensional geometries were built and meshed from the real centrifuge geometry. The CFD results show a boundary layer of axially fast moving fluid at the gas-liquid interface. Below this layer there is a thin recirculation. The obtained tangential velocity values are lower than the ones for the rigid-body motion. Also, the trajectories of the solid particles are evaluated.

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Characterization of flow intensity in continuous centrifuges for the development of laboratory mimics

Cited by 88 publications

References 13 publications

A Numerical Study of the Impact of Radial Baffles in Solid Bowl Centrifuges Using Computational Fluid Dynamics

A Numerical Study of the Impact of Radial Baffles in Solid Bowl Centrifuges Using Computational Fluid Dynamics

Micro biochemical engineering to accelerate the design of industrial‐scale downstream processes for biopharmaceutical proteins

Multiphase CFD Simulation of a Solid Bowl Centrifuge

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