Characterization of fusidic acid-resistant Staphylococcus aureus isolates in the community of Casablanca (Morocco)

Elazhari, Mohamed; Abu-Quatouseh, Luay F.; Elhabchi, Driss; Zerouali, Khalid; Dersi, Noureddine; Saı̈le, Rachid; Timinouni, Mohammed; Becker, Karsten

doi:10.1016/j.ijmm.2011.10.002

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…The size of the nodes represents the number of isolates included in that type Patients with hand eczema in Östergötland County are rarely treated with antibiotics, systemically or locally, which is reflected in the low prevalence of resistance and resistance genes in S. aureus isolated from patients. The fusidic acid resistant t127/CC1 clone colonizing three patients in our study has previously been frequently isolated around the globe [33][34][35].…”

Section: Discussionmentioning

confidence: 67%

Staphylococcus aureus colonization related to severity of hand eczema

Mernelius

Carlsson

Henricson

et al. 2016

Eur J Clin Microbiol Infect Dis

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Knowledge on Staphylococcus aureus colonization rates and epidemiology in hand eczema is limited. The aim of this study was to clarify some of these issues. Samples were collected by the "glove juice" method from the hands of 59 patients with chronic hand eczema and 24 healthy individuals. Swab samples were taken from anterior nares and throat from 43 of the 59 patients and all healthy individuals. S. aureus were spa typed and analysed by DNA-microarray-based genotyping. The extent of the eczema was evaluated by the hand eczema extent score (HEES). The colonization rate was higher on the hands of hand eczema patients (69 %) compared to healthy individuals (21 %, p < 0.001). This was also seen for bacterial density (p = 0.002). Patients with severe hand eczema (HEES ≥ 13) had a significantly higher S. aureus density on their hands compared to those with milder eczema (HEES = 1 to 12, p = 0.004). There was no difference between patients and healthy individuals regarding colonization rates in anterior nares or throat. spa typing and DNA-microarray-based genotyping indicated certain types more prone to colonize eczematous skin. Simultaneous colonization, in one individual, with S. aureus of different types, was identified in 60-85 % of the study subjects. The colonization rate and density indicate a need for effective treatment of eczema and may have an impact on infection control in healthcare.

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Section: Discussionmentioning

confidence: 67%

Staphylococcus aureus colonization related to severity of hand eczema

Mernelius

Carlsson

Henricson

et al. 2016

Eur J Clin Microbiol Infect Dis

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“…It is noteworthy that this is in contrast to isolates from individuals from remote regions, such as Pygmies, where resistance to penicillin (35.3%), co‐trimoxazole (11.8%) and tetracycline (5.8%) was clearly lower . There seems to be a tendency for there to be higher rates of resistance to fusidic acid in North Africa (13–62%) than in sub‐Saharan Africa (0–2%) . Data on the prescription and use of antibiotics are scarce for urban populations and absent for remote populations.…”

Section: Antimicrobial Resistancementioning

confidence: 81%

New epidemiology of Staphylococcus aureus infection in Africa

Schaumburg

Alabi

Peters

et al. 2014

Clinical Microbiology and Infection

149

146

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Research on African Staphylococcus aureus has been largely neglected in the past, despite the cultural and geographical diversity in Africa, which has a significant impact on the epidemiology of this pathogen. The polarity between developed urban societies and remote rural populations (e.g. Pygmies), combined with close contact with animals (e.g. livestock and domestic animals, and wildlife), makes the epidemiology of S. aureus on the African continent unique and fascinating. Here, we try to draw an epidemiological picture of S. aureus colonization and infection in Africa, and focus on the wide spread of Panton-Valentine leukocidin-positive isolates, the emergence of the hypervirulent methicillin-resistant S. aureus (MRSA) clone USA300, and the dissemination of the typical African clone MRSA sequence type 88.

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“…In addition, we related the genotypic characterization to background information from the patients from whom the isolates originated. Finally, we assessed the clonal relationship between the fusidic acid-resistant S. aureus by means of spa typing, because both fusB and fusC have been linked to specific spa types [6,11]. For all our objectives, we stratified our results by methicillin-susceptible S. aureus (MSSA) and MRSA, because of previously observed differences in fusidic acid resistance genotypes [12].…”

mentioning

confidence: 99%