Characterization of glycoproteins in submandibular acinus and saliva of rats elicited by pilocarpine.

Masuhara, Taizo; Iwabuchi, Yoshiki

doi:10.2330/joralbiosci1965.26.280

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…We found that characteristic glycoproteins in the acini are secreted into the saliva after stimulation by the non-specific 1 -adrenergic agent isoproterenol (15), as well as after stimulation by the cholinergic agent pilocar pine (16) and by substance P (17), whereas glycoproteins characteristic of the granular convoluted tubules are secreted in response to the a,-adrenergic agent, methoxamine (18,19).…”

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Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.

1988

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Abstract-The actions of dobutamine (DOB) and terbutaline (TER) on the secretion of marker glycoprotein (GP) from the secretory cells of the glands and secretion of fluid from rat submandibular gland (SMG) were investigated in combination with two antagonists, metoprolol (MET) and ICI-118551 (ICI). The ED50 value of fluid secretion was 8.7 mg/kg for DOB and 5.9 mg/kg for TER. MET, adminis tered prior to either agonists at a dose of 40 mg/kg, inhibited the fluid secretion. However, the blocking effects of ICI were considerably lower than those of MET. The electrophoretic profiles of GP in DOB-evoked saliva were similar to those in TER-evoked saliva, and included two characteristic main bands of GP I (130 KDa) and GP IV (21.5 KDa) from the acinar cells and a minor band of GP III (31 KDa) which originated in the cells of the granular tubules.When MET was administered at a dose of 5 mg/kg prior to DOB, the intensity of band I decreased, whereas that of band III did not change.These results showed that the SMG of rats contains both ,31 and i92-adrenoceptors and that (3-receptors which mediate the secretion of G P from the acinus and fluid from the gland are mainly of the 31-subtype.

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confidence: 93%

Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.

1988

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“…In addition, substance P was proposed to act on acinar and duct cells of the rat submandibular gland by analysis of elec trolytes in the peptide-evoked saliva (6). We reported previously that glycoprotein species markedly differ between acini and granular convoluted tubules of the rat submandibular gland (7) and that character istic glycoprotein species in acini are secreted into the saliva by 8-adrenergic and cholinergic agonists, whereas those in granular con voluted tubules are secreted by a-adrenergic agonists (8)(9)(10). The present study was carried out to elucidate the action site of substance P on the rat submandibular gland by comparing electrophoretic profiles of glycoprotein species in isolated functional segments of the gland with those in substance P-evoked saliva.…”

Section: Substancementioning

confidence: 99%

“…As reported previously, there is an electro phoretic difference in glycoprotein species between acini and granular convoluted tubules of the rat submandibular gland (7). Accordingly, it is possible to determine the action site of various autonomic agents on the functional segments of the gland by comparing electrophoretic patterns of glycoprotein species in evoked saliva with those of acini or granular convoluted tubules (8)(9)(10).…”

Section: Substancementioning

confidence: 99%

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Effects of Substance P on Glycoprotein Secretion from Acinar Cells of the Rat Submandibular Gland

Iwabuchi

Aoki

Masuhara

1986

Japanese Journal of Pharmacology

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Abstract-The action of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland was described in this report. Salivation elicited by i.v. injection of 0.5 to 20 ug/kg of substance P was increased dose-dependently, and its flow rate was highest at the first 1 min. Major glycoprotein species secreted into saliva by substance P-stimulus were shown to be electrophoretically identical with those found in acini, but not granular convoluted tubules. These results support the view that substance P acts on acinar cells of the submandibular gland and stimulates secretion of saliva from the cells.

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Effects of Dobutamine and Terbutaline on the Secretion of Glycoproteins from the Acinar Cells of the Rat Submandibular Gland

Iwabuchi

Aoki

Masuhara

1988

Japanese Journal of Pharmacology

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Characterization of glycoproteins in submandibular acinus and saliva of rats elicited by pilocarpine.

Cited by 11 publications

References 8 publications

Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.

Effects of dobutamine and terbutaline on the secretion of glycoproteins from the acinar cells of the rat submandibular gland.

Effects of Substance P on Glycoprotein Secretion from Acinar Cells of the Rat Submandibular Gland

Effects of Dobutamine and Terbutaline on the Secretion of Glycoproteins from the Acinar Cells of the Rat Submandibular Gland

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