Characterization of gut microbiota in adults with coronary atherosclerosis

Abstract

Background Cardiovascular disease, which is mainly caused by coronary atherosclerosis, is one of the leading causes of death and disability worldwide. Gut microbiota likely play an important role in coronary atherosclerosis. This study aims to investigate the microbiota profile of adults with coronary atherosclerosis to provide a theoretical basis for future research. Methods Fecal samples were collected from 35 adult patients diagnosed with coronary atherosclerosis and 32 healthy adults in Nanjing, China, and the V3-V4 region of 16S rDNA genes was sequenced using high-throughput sequencing. Differences in alpha diversity, beta diversity, and gut microbiota composition between the two groups were then compared. Results A beta diversity analysis revealed significant differences between adults with coronary atherosclerosis and controls, but there was no statistical difference in alpha diversity between the two groups. There were also differences in the composition of the gut microbiota between the two groups. The genera, Megamonas, Streptococcus, Veillonella, Ruminococcus_torques_group, Prevotella_2, Tyzzerella_4, were identified as potential biomarkers for coronary atherosclerosis. Conclusion There are some differences in the gut microbiota of adults with coronary atherosclerosis compared to healthy adults. The insights from this study could be used to explore microbiome-based mechanisms for coronary atherosclerosis.

Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation

“…[30][31][32] Studies have concluded that the diversity of fecal bacteria is reduced or significantly altered when the host experiences pathological conditions. 30 Dramatically decreased αdiversity parameters of intestinal flora diversity were detected in various diseases, including hypertension, 33 coronary atherosclerosis, 34 and Parkinson's disease. 35 In the present study, it was observed that the αdiversity is decreased in both the Pon1 KO group and the overexpression group compared to WT.…”

“…The diversity of gut bacteria has been widely considered a crucial characteristic linked to health status and multiple diseases. It has been previously reported that the stability of α‐diversity indicates a healthy status of the intestinal microbiome, and both suppressed and increased α‐diversity represents a signature of gut microbial disorders, which is frequently associated with diseases, including Pon1 ‐related diseases 30–32 . Studies have concluded that the diversity of fecal bacteria is reduced or significantly altered when the host experiences pathological conditions 30 .…”

“…It has been previously reported that the stability of α‐diversity indicates a healthy status of the intestinal microbiome, and both suppressed and increased α‐diversity represents a signature of gut microbial disorders, which is frequently associated with diseases, including Pon1 ‐related diseases 30–32 . Studies have concluded that the diversity of fecal bacteria is reduced or significantly altered when the host experiences pathological conditions 30 . Dramatically decreased α‐diversity parameters of intestinal flora diversity were detected in various diseases, including hypertension, 33 coronary atherosclerosis, 34 and Parkinson's disease 35 .…”

Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study

“…Remarkably, the Ruminococcus_torques group was the only shared taxon that was differentially enriched in samples from individuals with either hyperplastic polyps or conventional adenomas. Members of the Ruminococcus torques group have been positively associated with proinflammatory diets and, as also occurs with Ruminococcus gnavus (both were differentially enriched in the group with conventional adenomas), were found to be increased in several inflammatory processes and diseases [ 41 , 42 , 43 ]. Ruminococcus torques has been recently identified as a “driver” in the initiation and progression of the cancerous process [ 44 ].…”