Characterization of histamine receptors in the ureter of the dog

Dodel, Richard; Häfner, D.; Borchard, U.

doi:10.1016/s0014-2999(96)00765-0

Cited by 12 publications

(7 citation statements)

References 65 publications

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“…5‐HT significantly increased contraction frequency of ureter peristalsis in anaesthetized pigs after intravenous administration in a dose‐dependent manner (Figure 2A). In accordance with our work on the ureteral smooth muscle, stimulating effects of 5‐HT in several in vitro studies on specimens from dogs (Dodel et al ., 1996), man (Dodel et al ., 1996; Kuwahara, 1983; Long & Nergardh, 1978; Gidener et al ., 1995; 1999; Iselin et al ., 1997) and guinea‐pigs (Benzi et al ., 1970) have been shown, and in vivo studies in dog ureters (Abrahams & Pickford, 1956; Catacutan‐Labay et al ., 1966; Boatman et al ., 1967) also support our findings. The contractile response has been shown to be biphasic in dogs (Mazzella & Schroeder, 1960) but this was not observed in the present experiments in pigs, as can be seen in Figure 1.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that receptors previously labelled 5-HT 1 -like are a heterogeneous population of 5-HT 1B , 5-HT 1D and 5-HT 7 receptors (Saxena et al, 1998). 5-HT is well known to induce ureteral contractions in isolated ureter preparations from dierent species (Hertle & Nawrath, 1986;Dodel et al, 1996;Kuwahara, 1983;Long & Nergardh, 1978;Gidener et al, 1995;1999;Benzi et al, 1970;Iselin et al, 1997) and in vivo (Abrahams & Pickford, 1956;Catacutan-Labay et al, 1966;Boatman et al, 1967). Nevertheless it is still unclear which 5-HT receptor subtype is responsible for the stimulating eect and whether 5-HT is physiologically involved in ureter motility.…”

Section: Introductionmentioning

confidence: 99%

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Effects of ketanserin and DOI on spontaneous and 5‐HT‐evoked peristalsis of the pig ureter in vivo

Hauser

Mevissen

Weiss

et al. 2002

British J Pharmacology

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1 The in¯uence of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on the ureter motility was investigated in vivo on intact ureters of anaesthetized pigs. Drugs were administered intravenously or topically. 2 5-HT induced a dose-dependent increase in the frequency of ureter contractions in anaesthetized pigs when given intravenously (0.0001 ± 1 mg kg 71 ; ED 50 0.066 mg kg 71 ) or topically (0.001 ± 1 mg ml 71 ; EC 50 0.043 mg ml 71 ). Signi®cant increases in heart rate and blood pressure were observed when the drug was given intravenously but not topically. 3 The 5-HT 2A agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) increased the frequency of ureteral contractions in a dose-dependent manner (1 ± 300 mg kg 71 i.v.). Calculation of ED 50 indicated this compound to be about 1.5 times more potent with an e cacy of 23% compared to 5-HT. 4 The 5-HT 2A/2C antagonist, ketanserin (0.5 mg kg 71 ) and the 5-HT 2C antagonist, methysergide (1 mg kg 71 ) antagonized the 5-HT-induced ureter peristalsis when given intravenously. Contraction amplitude, blood pressure and heart rate were not a ected by the antagonists. 5 Intravenous (0.0001 ± 1 mg kg 71 ) and topical (0.0001 ± 1 mg ml 71 ) ketanserin signi®cantly decreased the frequency of spontaneous ureteral contractions to about 30% of controls, which could be partly reversed by 5-HT (0.3 mg kg 71 i.v.). The contraction amplitude, contractions of the contralateral, saline perfused ureter, heart rate and mean arterial blood pressure were not a ected. 6 Thus, contractility of porcine ureter is mediated by 5-HT 2 receptors. Their antagonists ketanserin and methysergide seem to be promising drugs for treatment of acute ureteric colic or in preparing the ureter for ureteroscopy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of ketanserin and DOI on spontaneous and 5‐HT‐evoked peristalsis of the pig ureter in vivo

Hauser

Mevissen

Weiss

et al. 2002

British J Pharmacology

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“…It was demonstrated that two types of histamine receptors modulate the contractile activity of the human ureter, whereby histamine H 1 -receptors cause contraction and histamine H 2 -receptors cause slight relaxation [58] . H 1 -receptors have been shown to be predominant over H 2 -receptors with regard to efficacy of coupling in the human ureteral muscle.…”

Section: Histaminementioning

confidence: 99%

Physiology and Pharmacology of the Human Ureter: Basis for Current and Future Treatments

Canda

Turna²,

Cinar

et al. 2007

Urol Int

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Introduction: This article sets out to be a review regarding agents that affect contraction and relaxation of the ureter in order to establish a basis for current and future treatments for upper urinary tract obstruction. Material and Methods: A complete review of the English literature using MEDLINE was performed between 1960 and 2007 on ureter physiology and pharmacology with special emphasis on signal transduction mechanisms involved in the contractile regulation of the human ureter. Results: Activation of muscarinic and adrenergic receptors increases the amplitude of ureteral contractions. The sympathetic nerves modulate the contractions by α-adrenoceptors and relaxation by β-adrenoceptors. The purinergic system is important in sensory/motor functions and ATP is an important non-adrenergic non-cholinergic (NANC) agent causing contraction. Nitric oxide (NO) is a major inhibitory NANC neurotransmitter causing relaxation. Serotonin causes contraction. Prostaglandin-F₂α contracts whereas prostaglandin-E₁/E₂ relaxes the ureter. Phosphodiesterases (PDE) and the Rho-kinase pathway have recently been identified in the human ureter. PDE-IV inhibitors, K⁺ channel openers, calcium antagonists, α₁-adrenoceptor antagonists and NO donors seem to be promising drugs in relieving obstruction and facilitating stone passage. Conclusions: Further understanding of the ureteral function and pharmacology may lead to the discovery of promising new drugs that could be useful in relieving ureteral colic, facilitating spontaneous stone passage, preparing the ureter for ureteroscopy as well as acting adjunctive to extracorporeal shock-wave lithotripsy.

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“…Our previous findings suggest that contractile responses in ureters isolated from different ages vary with agonists, with ureteral contractions to α 1-adrenoceptor stimulation being greater in older animals, whilst contractions to 5-HT were smaller in younger animals (Lim, Chess-Williams, & Sellers, 2018a). However, the influence of age on responses mediated by carbachol and histamine, which have both been suggested to mediate ureteral contraction (Dodel, Hafner, & Borchard, 1996;Yalcin et al, 2013), have not been studied.…”

Section: Introductionmentioning

confidence: 98%

A porcine model of ureteral contractile activity: Influences of age, tissue orientation, region, urothelium, COX and NO

Lim

Chess-Williams

Sellers

2020

Journal of Pharmacological and Toxicological Methods

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Introduction: We aimed to investigate factors contributing to ureteral responses and establish a reliable porcine model for studying ureteral contractility. Methods: Isolated ureteral strips from young (6-month old) and older (3-year old) pigs were mounted in organ baths and subjected to phenylephrine, 5-HT, carbachol and histamine.Ureteral strips developed bursts of contractile activity which was measured as area under the curve (AUC) and frequency. Phenylephrine and 5-HT-induced responses of proximal and distal ureters were obtained, in the presence and absence of indomethacin (10μM) and L-NNA (100μM), and the influence of an intact mucosa was examined.Results: Phenylephrine and 5-HT-induced contractile responses were greater than those to carbachol in the porcine ureter. In fact, responses to carbachol were only present in ureters from older animals. Ureters suspended longitudinally had increased phenylephrine-induced contractions compared to those suspended circularly (p<0.05). A greater amount of tissue strips developed spontaneous contractions from the proximal region compared to distal (83% vs 25%). There was an increase in maximum phenylephrine-induced responses in the distal ureter when compared to the proximal ureter (p<0.05). In the presence of indomethacin, only 5-HT-induced contractions in the young animals were depressed (p<0.05) while L-NNA did not affect any ureteral responses. The intact mucosa significantly decreased contractile responses to phenylephrine and 5-HT in the porcine ureter.Discussion: The complexity of ureteral contractions depicting bursts of phasic activity requires AUC assessment. Porcine ureteral contractile properties, such as regional differences, influence of mucosa and lack of response to carbachol, are similar to those reported in the literature for human ureter.

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Characterization of histamine receptors in the ureter of the dog

Cited by 12 publications

References 65 publications

Effects of ketanserin and DOI on spontaneous and 5‐HT‐evoked peristalsis of the pig ureter in vivo

Effects of ketanserin and DOI on spontaneous and 5‐HT‐evoked peristalsis of the pig ureter in vivo

Physiology and Pharmacology of the Human Ureter: Basis for Current and Future Treatments

A porcine model of ureteral contractile activity: Influences of age, tissue orientation, region, urothelium, COX and NO

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