Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13

Vieites, José María; Torre, Raúl de la; Ortega, María A.; Montero, Trinidad; Peco, Jose Marı́a; Sánchez–Pozo, Antonio; Gil, Ángel; Suárez, Antonio

doi:10.1016/s0378-1119(03)00562-6

Cited by 31 publications

(29 citation statements)

References 16 publications

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“…1c, d). We also stained PC12 cells with anti-CD200R, but no positive immunostaining was observed (data not shown), which is consistent with previous studies showing that CD200R is restricted mainly to myeloid lineage [36][37][38].…”

Section: Basal Cd200r Expression In Mdms From Pd Patients Is Not Alteredsupporting

confidence: 91%

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Luo

Zhang

et al. 2009

Neurochem Res

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Microglia are the representative myeloid cells in the brain, and their over-activation plays an important role in the pathogenesis of Parkinson's disease (PD). Microglia activation is believed to be regulated by the CD200-CD200R signaling. As the peripheral counterpart of microglia, monocyte-derived macrophages (MDMs) share the same progenitor and antigen markers, and they have similar biological behaviors and mirror microglial function in the brain. Here, we studied CD200R expression and its regulation in MDMs from 32 PD cases, 27 age-matched old controls, and 28 young controls. We found that the basal CD200R expression is similar in MDMs from young control, old control and PD patients. However, the induction of CD200R expression in MDMs under various conditions is impaired in the old groups, especially in PD patients. There was a selective decrease in CD200R expression induced by co-culture with dying PC12 cells in MDMs from PD cases, as compared with MDMs from the age-matched controls. We also found that the inducible CD200R expression correlated inversely with the onset age of PD and to tumor necrosis factor-alpha (TNF-alpha) released from MDMs. These results suggest an intrinsic abnormality in the CD200-CD200R signaling in MDMs during aging and, especially, in PD. We speculate that in the PD brain,microglia might undergo abnormalities similar to MDMs.

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Section: Basal Cd200r Expression In Mdms From Pd Patients Is Not Alteredsupporting

confidence: 91%

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Luo

Zhang

et al. 2009

Neurochem Res

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“…This CD200-mediated suppression is mediated through interaction with a receptor, CD200R, on a target cell surface, and a family of CD200Rs has been described, with different members showing unique tissue distribution and function (16,18,(42)(43)(44). The mechanisms by which CD200-CD200R interaction contributes to immunoregulation and prolongation of tissue allograft survival remain unclear, although we and others have reported significant suppression of inflammatory responses and the induction of regulatory T cells as being prominent among the likely candidates (45)(46)(47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 84%

Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts

Gorczynski

Chen

et al. 2009

The Journal of Immunology

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CD200, a type 2 transmembrane molecule of the Ig supergene family, can induce immunosuppression in a number of biological systems, as well as promote increased graft acceptance, following binding to its receptors (CD200Rs). Skin and cardiac allograft acceptance are readily induced in transgenic mice overexpressing CD200 under control of a doxycycline-inducible promoter, both of which are associated with increased intragraft expression of mRNAs for a number of genes associated with altered T cell subset differentiation, including GATA-3, type 2 cytokines (IL-4, IL-13), GITR, and Foxp3. Interestingly, some 12–15 days after grafting, induction of transgenic CD200 expression can be stopped (by doxycycline withdrawal), without obvious significant effect on graft survival. However, neutralization of all CD200 expression (including endogenous CD200 expression) by anti-CD200 mAb caused graft loss, as did introduction of an acute inflammatory stimulus (LPS, 10 μg/mouse, delivered by i.p. injection). We conclude that even with apparently stably accepted tissue allografts, disruption of the immunoregulatory balance by an intense inflammatory stimulus can cause graft loss.

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“…they detected two different coding regions within chromosome 3 with homology to mouse cd200R encoding for isoforms cd200R2/cd200Rla. the mouse cd200 and cd200R genes are located on chromosome 16 (39). it was revealed that there are several related genes in the mouse genome that encode cd200R isoforms termed cd200Rl (receptor like -cdR200Rla -e).…”

Section: ) Cd200 and Cd200r Gene Encoding And Isoformsmentioning

confidence: 99%

CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function

Holmannová

Koláčková

Kondělková

et al. 2012

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: cd200/cd200R are highly conserved type i paired membrane glycoproteins that belong to the ig superfamily containing a two immunoglobulin -like domain (v, c). cd200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. the interaction between cd200/cd200R results in activation of the intracellular inhibitory pathway with Rasgap recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of t cells to the treg subset, upregulates indoleamine 2,3 -dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL -10 and TGF -β synthesis. CD200/CD200R are required for maintaining self -tolerance. Many studies have demonstrated the importance of cd200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.

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Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13

Cited by 31 publications

References 16 publications

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts

CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function

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