Characterization of human papillomavirus infection in north Taiwan

Abstract

The detection of human papillomavirus (HPV) is very important for the evaluation of preventative strategies for cervical cancer. The major objective of this study was to characterize the prevalence of different genotypes of HPV in north Taiwan to contribute to the epidemiological knowledge of HPV infections. Papanicolaou (Pap) cervical smears were collected from 10,543 women aged between 14 and 87 years. The polymerase chain reaction (PCR) and DNA array hybridization techniques were used to genotype 51 different HPV strains. HPV was detected in 1,577 women, which gave an overall HPV prevalence rate of 15%. Forty-eight different genotypes were found in these patients, which included 9.7% that were high-risk HPV (HR-HPV) genotypes. The most common types of HR-HPV in patients, in descending order of frequency, were HPV 52, 16, 58, 56, 39, 51, 18, 68, 31, 33, 59, 45, and 35. HPV 52 was the most frequent type in every age group. The four most common HR-HPV types were found in 56.6% of the patients infected with HR-HPV. In cases that were infected with multiple HPV genotypes, 69.2% had at least one HR-HPV genotype. The rate of infection with HR-HPV was higher in the younger age groups than the older ones. In conclusion, 48 HPV genotypes were identified from a large study of cervical screening samples and the prevalence of HPV genotypes in different age groups was very diverse. The formulation of a public health strategy for HPV vaccination should take into account the prevalence of various HR-HPV/LR-HPV genotypes.

Human papillomavirus type‐specific prevalence in women referred for colposcopic examination in Beijing

“…The results show that new genotype infection rates in cervicitis and abnormal histological lesions group were higher than those of the healthy control group, but infection rates of new genotypes in the cervicitis, cervical intraepithelial neoplasia grade 1, and cervical intraepithelial neoplasia grade 2 or grade 3 groups were higher than those of the cervical cancer group, which indicates that infection by the new genotypes was related to cervical lesions. However, in accord with other reports [Wang et al, ], they did not increase the risk of cervical cancer. Ye et al [] investigated distribution of new genotypes 26, 82, 40, 54, 61, 57, and 83 in Zhejiang Province, south‐eastern China.…”

Human Papillomavirus (HPV) Infection in Women Participating in Cervical Cancer Screening from 2006 to 2010 in Shenzhen City, South China

“…The prevalence of HPV infection in different age groups was very diverse (Wang et al, 2010). This study showed that the prevalence of HPV was higher in the younger age groups than the older ones, and the highest HPV prevalence was found in age group ≤ 25-years old, and increasing ages were significantly associated with the decreasing prevalence of HPV infection from 26 to 45 years old, which was consistent with the published results (Cibas et al, 2007).…”

“…Our findings showed a relatively high prevalence of HPV (13.80%) among females in Shenzhen city, and similar ratios were found in Taipei and five areas of mainland China, but higher than that reported in North India, and lower in Italy (Datta et al, 2010;Wang et al, 2010;Guido et al, 2013;Wu et al, 2013). The reasons could be explained by the different detection methodologies, and the ethical, racial, or geographic diversity.…”

An exploration of human papillomavirus‐related cervical cancer prevention experiences among college women: a descriptive qualitative approach

“…It has been reported that HPV was detected in 45Á3% of adolescent girls and up to 80% of them were infected with HPV during the entire two-year longitudinal study in the US (Brown et al 2005). Similarly, the highest rates of HPV prevalence were found in women younger than 29 years of age in Taiwan (Wang et al 2010).…”

“…Similarly, the highest rates of HPV prevalence were found in women younger than 29 years of age in Taiwan (Wang et al . ).…”