2007
DOI: 10.1111/j.1365-2958.2007.05597.x
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Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence

Abstract: Summary Listeria monocytogenes is a Gram

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Cited by 144 publications
(189 citation statements)
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“…This hypothesis has proven to be correct for Bacillus cereus, Clostridium difficile, Listeria monocytogenes, S. aureus, Streptococcus pneumoniae, and Streptococcus pyogenes (14,51,87,132,147,149). Similar to CodY in B. subtilis, CodY in pathogenic bacteria represses genes involved in amino acid transport, catabolism, and biosynthesis.…”
Section: Catabolite-responsive Regulatorsmentioning
confidence: 99%
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“…This hypothesis has proven to be correct for Bacillus cereus, Clostridium difficile, Listeria monocytogenes, S. aureus, Streptococcus pneumoniae, and Streptococcus pyogenes (14,51,87,132,147,149). Similar to CodY in B. subtilis, CodY in pathogenic bacteria represses genes involved in amino acid transport, catabolism, and biosynthesis.…”
Section: Catabolite-responsive Regulatorsmentioning
confidence: 99%
“…In C. difficile, CodY binds to the promoter region of the tcdR gene, which codes for an alternative sigma factor that is required for the synthesis of the large clostridial cytotoxins toxin A and toxin B (51). CodY in L. monocytogenes affects amino acid transport, catabolism, and biosynthesis; however, its function in pathogenesis is less clear (14). The inactivation of codY in L. monocytogenes affects motility and chemotaxis but has only a slight effect on virulence in a murine listeriosis model (14).…”
Section: Catabolite-responsive Regulatorsmentioning
confidence: 99%
See 1 more Smart Citation
“…The gene encoding the Group D protein Lmo2666, annotated as a galactitolspecific PTS system IIB component, was previously found to be positively regulated by s B in L. monocytogenes strains representing lineages I and IIIB (which has been redesignated IV), but not in the lineage II strain 10403S (Oliver et al, 2010). lmo2666 has also been found to be differentially regulated in comparisons between L. monocytogenes EGD-e and mutants that did not express the regulators CodY and DegU (Bennett et al, 2007;Williams et al, 2005), suggesting regulatory interactions that govern transcription of this gene.…”
mentioning
confidence: 99%
“…First identified in Bacillus subtilis as a factor that represses stationary phase genes during exponential growth in rich medium (11), CodY is now known to provide a critical regulatory link between metabolism and pathogenesis in bacteria important for human health (5,6,(12)(13)(14)(15)(16). CodY is activated as a DNA-binding protein in vitro by at least two classes of metabolites: the branched-chain amino acids [BCAAs; i.e., isoleucine, leucine, and valine (ILV)] and GTP (17)(18)(19)(20)(21).…”
mentioning
confidence: 99%