Characterization of Isoforms of the Lectin Isolated from the Red Algae Bryothamnion seaforthii and Its Pro-Healing Effect

Neto, Luiz Gonzaga do Nascimento; Carneiro, Rômulo Farias; Silva, Suzete Roberta da; Silva, Bruno Rocha da; Arruda, Francisco Vassiliepe Sousa; Carneiro, Victor Alves; Nascimento, Kyria S.; Saker-Sampaio, Silvana; Silva, Valdemiro Amaro da; Porto, Ana Lúcia Figueiredo; Cavada, Benildo S.; Sampaio, Alexandre Holanda; Teixeira, Edson Holanda; Nagano, Celso Shiniti

doi:10.3390/md10091936

Cited by 29 publications

(7 citation statements)

References 41 publications

(62 reference statements)

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“…Owing to potential of lectins for promoting healing, they act as a promising candidate in treatment of skin wounds (Chahud et al 2009;Nascimento Neto et al 2011). A lectin from B. seaforthii has a pro-healing activity as it accelerates healing of skin wounds by exerting activity on migration of polymorphonuclear cells towards injured site (Nascimento-Neto et al 2012).…”

Section: Miscellaneous Applicationsmentioning

confidence: 99%

Lectins from red algae and their biomedical potential

Singh

Walia

2017

J Appl Phycol

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Lectins are unique proteins or glycoproteins of nonimmune origin that bind specifically to carbohydrates. They recognise and interact reversibly to either free carbohydrates or glycoconjugates, without modifying their structure. Lectins are highly diverse and widely distributed in nature and have been extensively reported from various red algae species. Numerous red algae species have been reported to possess lectins having carbohydrate specificity towards complex glycoproteins or high-mannose N-glycans. These lectin-glycan interactions further trigger many biochemical responses which lead to their extensive use as valuable tools in biomedical research. Thus, owing to their exceptional glycan recognition property, red algae lectins are potential candidate for inhibition of various viral diseases. Hence, the present report integrates existing information on the red algae lectins, their carbohydrate specificity, and characteristics of purified lectins. Further, the review also reports the current state of research into their anti-viral activity against various enveloped viruses such as HIV, hepatitis, influenza, encephalitis, coronavirus and herpes simplex virus and other biomedical activities such as anti-cancer, anti-microbial, anti-inflammatory, antinociceptive and acaricidal activities.

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Section: Miscellaneous Applicationsmentioning

confidence: 99%

Lectins from red algae and their biomedical potential

Singh

Walia

2017

J Appl Phycol

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“…However, this trial was a pilot study—we planned to evaluate our idea in a standard minimum sample size of patients with renal stones. Another important limitation was the lack of more accurate objective indices like computed tomography (Gonzaga do Nascimento‐Neto et al, ) scan for the assessment of kidney stone size. However, due to the high cost, it was difficult to perform computed tomography scan.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

Movaghati

Yousefi

Saghebi³

et al. 2019

Phytotherapy Research

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Preclinical studies have shown beneficial effects of black seed (Nigella sativa L.) in the prevention and treatment of renal stones. Hence, we designed a study to evaluate the renal‐stone‐dissolving efficacy of black seed. Sixty patients with renal stones were randomly enrolled in two arms of a randomized, triple‐blind, placebo‐controlled, clinical trial. The patients were treated by black seed capsules (500 mg) or placebo two times per day for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention. In the black seed group, 44.4% of patients excreted their stones completely, and the size of the stones remained unchanged and decreased in 3.7% and 51.8% of patients, respectively. In contrast, in the placebo group, 15.3% of the patients excreted their stones completely, 11.5% had reduction in stone size, 15.3% had increase in stone size, and 57.6% had no change in their stone size. The difference in the mean size of renal stones after the study was significant between the two groups (p < 0.05). N. sativa L., as compared with placebo, is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.

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“…A lectin isolated from the marine red algae Bryothamnion seaforthii (BSL) demonstrated prohealing potential on skin wounds in mice [ 123 ]. Induced wounds in dorsal thoracic region of mice were submitted to topical treatment with BSL.…”

Section: Lectins For Healing Applicationsmentioning

confidence: 99%

“…After 7 and 12 days, treatment with BSL promoted the synthesis of collagen by fibroblasts and active presence of young skin annexes, promoting the restructuration of the luminal epithelium and an effective wound closure. Here, BSL plays an immunomodulatory effect on immune cells during inflammatory and proliferative phases, where BSL demonstrated stimulatory activity on the migration of polymorphonuclear cells to injured site, and activation of fibroblasts, resulting in the prohealing effect [ 123 ].…”

Section: Lectins For Healing Applicationsmentioning

confidence: 99%

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

Coelho

Silva

Lima

et al. 2017

Evidence-Based Complementary and Alternative Medicine

160

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Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.

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Characterization of Isoforms of the Lectin Isolated from the Red Algae Bryothamnion seaforthii and Its Pro-Healing Effect

Cited by 29 publications

References 41 publications

Lectins from red algae and their biomedical potential

Lectins from red algae and their biomedical potential

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

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