Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Abstract

Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

Synthesis and characterization of a polymeric network made of polyethylene glycol and chitosan as a treatment with antibacterial properties for skin wounds

“…25 In addition, the swelling time in PBS at 37 C and in PBS at room temperature of the networks was different; PEG network, PC-0.05% and PC-0.1% reached maximum swelling in approximately 24 h. However, PC-1%, PC-2% and PC-4% had the maximum swelling in PBS at both temperatures in 2 h. This behavior can be attributed to the size and number of pores that is determined by the crosslinking between PEG and chitosan. 21 In both solutions, PC-4% exhibited the lowest swelling capability (349.58 AE 47.58% at 37 C; 262.4 AE 52.54% at room temperature). The PEG hydrogel showed the highest percentage of swelling (930.55 AE 324.91% at 37 C; 614.16 AE 57.85% at room temperature).…”

“…The bands observed in the FT-IR of the PEG, chitosan and PC networks ( Figure 2) are similar with the FT-IR reported in literature. 15,[21][22][23] The synthesis of a new material was demonstrated with the appearance of bands from both polymers: PEG and chitosan. PEG network showed bands at 1108 cm À1 of C-O-H stretching and at 1724 cm À1 of the carboxylic acid from the acrylation of PEG.…”

“…The presence of pores in the networks was also observed by Gaitán-Tolosa et.al. 21 who synthesized ketoprofen-loaded PC system for wound dressing and they found pores of different sizes. However, the pore size was of 13.7 nm, since they loaded ketoprofen inside the networks, so they decreased the pore size to avoid the diffusion of the drug outside of the PC system.…”