2021
DOI: 10.1021/acs.langmuir.0c03039
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Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

Abstract: DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal re… Show more

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Cited by 65 publications
(57 citation statements)
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“…Here we report the development, among different lipid matrices, of novel DDS for tetracaine. Factorial design was used as a chemometric tool to elucidate the effect of excipients in the NLC supramolecular organization, providing robust systems with optimized structural properties for subsequent analyses 13 . Among other biophysical techniques, Raman imaging and SANS analyses disclosed details on the lipid matrix organization, that reduced the shelf stability of one optimized formulation.…”
Section: Introductionmentioning
confidence: 99%
“…Here we report the development, among different lipid matrices, of novel DDS for tetracaine. Factorial design was used as a chemometric tool to elucidate the effect of excipients in the NLC supramolecular organization, providing robust systems with optimized structural properties for subsequent analyses 13 . Among other biophysical techniques, Raman imaging and SANS analyses disclosed details on the lipid matrix organization, that reduced the shelf stability of one optimized formulation.…”
Section: Introductionmentioning
confidence: 99%
“…In principal, assembly of LNPs is achieved by rapid mixing of four lipids in ethanol with RNA molecules in an aqueous buffer (near pH 4) in a microfluidic or T-junction mixer [ [47] , [48] , [49] ].…”
Section: Difference In Formulationmentioning
confidence: 99%
“…Introducing and evolving ethanol loading procedures facilitated effective production of homogenous, small-size (diameter < 100nm) LNPs with high entrapment efficiency (>80%) [34,[56][57][58]. Over the years, many ionizable lipids have been developed, with a variety of features depending on the desired purpose.…”
Section: Ionizable Cationic Lipids Lnpsmentioning
confidence: 99%