Due to the unique geometry of the geomagnetic fields near the magnetic equator and low-latitude regions, the satellite communication system in the African sector is strongly influenced by the effects resulting from the accumulation of electrons in their ionosphere. Hence, this paper investigates the patterns of the vertical total electron content (VTEC) variation detected by the Global Positioning System (GPS) over low-latitude regions during a very low (2008 to 2009) and a high solar activity (2012 to 2013) phases. The study has been carried out by considering eight ground-based dual-frequency GPS receivers installed recently at different regions in Ethiopia. In this work, the diurnal, monthly, and seasonal variations in the GPS-VTEC have been analyzed. It has been found that the diurnal variability of VTEC has shown minimum values at around 0300 UT (0600 local time (LT)) and maximum values nearly between 1000 and 1300 UT (1300 and 1600 LT) during both the low and the high activity phases. Moreover, the maximum and minimum of monthly mean hourly VTEC values are observed in October and July, respectively, during both the low (2009) and the high solar activity (2012) phases. It has also been depicted that seasonal mean hourly VTEC values have shown maxima and minima in the March equinox and the June solstice, respectively, during both the low and the high solar activity phases.