Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI

Knutsen, Andrew K.; Vidhate, Suhas; McIlvain, Grace; Luster, Joshua; Galindo, Eric J.; Johnson, Curtis L.; Pham, Dzung L.; Butman, John A.; Mejía-Álvarez, Ricardo; Tartis, Michaelann; Willis, Adam M.

doi:10.1016/j.jmbbm.2022.105586

Cited by 8 publications

(14 citation statements)

References 54 publications

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“…This data brief supports the publication titled ‘Characterization of Material Properties and Deformation in the ANGUS Phantom During Mild Head Impacts’ by providing the foundational mechanical characterization data necessary to fabricate a head phantom with specified properties to analyze simulated mild head impacts [1] . This data brief characterizes two cranial components, brain tissue and skull.…”

Section: Objectivesupporting

confidence: 66%

“…An ideal formulation will minimally swell and remain optically clear for high-speed imaging. These formulations, for white and gray matter, achieve a storage modulus of 2000 or 1400 Pa, a loss modulus of 400 or 300 Pa, respectively, and a tan δ of 0.2 [1 , 3] . Hydrogels with increased linear acrylamide chains were formulated in an effort to obtain an increased viscous component thereby increasing the tan δ, the ratio of viscous to elastic forces [4] .…”

Section: Objectivementioning

confidence: 99%

“…Both formulations obtain a range of rheological properties desired for tissue scaffold and brain mimic applications. Based on Magnetic Resonance Elastography of healthy volunteers and indentation measurements of the bovine brain it was determined that an ideal hydrogel formulation to mimic storage and loss modulus of brain tissue would be 2000 Pa and 400 Pa for white matter and 1400 Pa and 300 Pa for gray matter, respectively, that would result in a tan δ of 0.2 [1 , 3] . Fig.…”

Section: Data Descriptionmentioning

confidence: 99%

“…Fig. 6 shows the average flexural stress for PLA samples with a 100% grid infill (n = 5) used in the skull of brain phantoms, with the ‘X’ signifying the fracture point [1] . Literature values for the flexural modulus of human skull is reported at 11.73 GPa [9] .…”

Section: Data Descriptionmentioning

confidence: 99%

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Mechanical characterization data of polyacrylamide hydrogel formulations and 3D printed PLA for application in human head phantoms

et al. 2023

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Section: Objectivesupporting

confidence: 66%

Section: Objectivementioning

confidence: 99%

Section: Data Descriptionmentioning

confidence: 99%

Section: Data Descriptionmentioning

confidence: 99%

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Mechanical characterization data of polyacrylamide hydrogel formulations and 3D printed PLA for application in human head phantoms

et al. 2023

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“…Various researchers use different methods to construct different layers. The existing phantom materials serve two distinct purposes-one to match the mechanical properties [26,27] and the other to match the electrical properties. Oftentimes, many of the electrically equivalent phantom head materials are not durable, which severely limits its applications.…”

Section: Introductionmentioning

confidence: 99%

Electrically Equivalent Head Tissue Materials for Electroencephalogram Study on Head Surrogates

Daru,

Rabby,

et al. 2024

Applied Sciences

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With the recent advent of smart wearable sensors for monitoring brain activities in real-time, the scopes for using Electroencephalograms (EEGs) and Magnetoencephalography (MEG) in mobile and dynamic environments have become more relevant. However, their application in dynamic and open environments, typical of mobile wearable use, poses challenges. Presently, there is limited clinical data on using EEG/MEG as wearables. To advance these technologies at a time when large-scale clinical trials are not feasible, many researchers have turned to realistic phantom heads to further explore EEG and MEG capabilities. However, to achieve translational results, such phantom heads should have matching geometric features and electrical properties. Here, we have designed and fabricated multilayer chopped carbon fiber–PDMS reinforced composites to represent phantom head tissues. Two types of phantom layers are fabricated, namely seven-layer and four-layer systems with a goal to achieve matching electrical conductivities in each layer. Desired electrical conductivities are obtained by varying the weight fraction of the carbon fibers in PDMS. Then, the prototype system was calibrated and tested with a 32-electrode EEG cap. The test results demonstrated that the phantom effectively generates a variety of scalp potential patterns, achieved through a finite number of internal dipole generators within the phantom sample. This innovative design holds potential as a valuable test platform for assessing wearable EEG technology as well as developing an EEG analysis process.

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Mechanically anisotropic phantoms for magnetic resonance elastography

Eckstein,

Yoon,

Ruding

et al. 2024

Magnetic Resonance in Med

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PurposeImaging phantoms with known anisotropic mechanical properties are needed to evaluate magnetic resonance elastography (MRE) methods to estimate anisotropic parameters. The aims of this study were to fabricate mechanically anisotropic MRE phantoms, characterize their mechanical behavior by direct testing, then assess the accuracy of MRE estimates of anisotropic properties using a transversely isotropic nonlinear inversion (TI‐NLI) algorithm.MethodsDirectionally scaled and unscaled lattices were designed to exhibit anisotropic or isotropic mechanical properties. Lattices were three‐dimensionally printed in poly(ethelyne glycol) diacrylate using a commercial digital light processing printer, then infilled with gelatin to form a composite material. Benchtop testing determined two shear stiffnesses, and , governing loading parallel and perpendicular to the symmetry axis, and two analogous Young's moduli and . From these measures, shear anisotropy = and tensile anisotropy = were calculated. Three phantoms were driven by a central actuator and imaged with MRE at frequencies from 300 to 500 Hz. From MRE data, the TI‐NLI algorithm estimated maps of , , and .ResultsIn benchtop tests, geometrically scaled lattice composites exhibited the following anisotropic properties: = 6.1 ± 0.7 kPa, = 0.83 ± 0.13, = 0.78 ± 0.09} (mean ± standard deviation). MRE of scaled lattice composites revealed elliptical wavefields; TI‐NLI analysis identified the following median property ranges: = 11–19 kPa, = 0.6–1.0, = 0.8–1.6}.ConclusionAnisotropic MRE phantoms are created by embedding anisotropic three‐dimensionally printed lattices into a softer matrix. The TI‐NLI algorithm accurately estimates spatial contrast in anisotropic properties.

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Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI

Cited by 8 publications

References 54 publications

Mechanical characterization data of polyacrylamide hydrogel formulations and 3D printed PLA for application in human head phantoms

Mechanical characterization data of polyacrylamide hydrogel formulations and 3D printed PLA for application in human head phantoms

Electrically Equivalent Head Tissue Materials for Electroencephalogram Study on Head Surrogates

Mechanically anisotropic phantoms for magnetic resonance elastography

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