2009
DOI: 10.1099/vir.0.014290-0
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Characterization of microRNAs encoded by the bovine herpesvirus 1 genome

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Cited by 45 publications
(56 citation statements)
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“…Indeed, the entire 122-nt BFV pri-miRNA sequence is fully conserved, with the exception of two nucleotides in the terminal loop of the miR-BF2 stem-loop that, based on previous work (31), are not predicted to affect miRNA processing or expression. Interestingly, comparison of the three highly expressed BFV miRNAs with known viral and cellular miRNAs revealed that the entire miR-BF1-5p seed sequence (nt 2 to 8) is conserved in miR-B5, which is expressed by bovine herpesvirus 1 (BHV-1) in infected cells (38). However, as the mRNA targets for miR-B5 are not currently known, this conservation is not currently informative as to miR-BF1-5p function.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the entire 122-nt BFV pri-miRNA sequence is fully conserved, with the exception of two nucleotides in the terminal loop of the miR-BF2 stem-loop that, based on previous work (31), are not predicted to affect miRNA processing or expression. Interestingly, comparison of the three highly expressed BFV miRNAs with known viral and cellular miRNAs revealed that the entire miR-BF1-5p seed sequence (nt 2 to 8) is conserved in miR-B5, which is expressed by bovine herpesvirus 1 (BHV-1) in infected cells (38). However, as the mRNA targets for miR-B5 are not currently known, this conservation is not currently informative as to miR-BF1-5p function.…”
Section: Discussionmentioning
confidence: 99%
“…The identification of an abundant transcript of 60 to 65 nt expressed from the OriLyt could be reminiscent of other viral pre-miRNAs recently identified to be expressed from the OriLyt regions of MCMV (8,17), RCMV (35), bovine herpesvirus (BoHV) (22), and HSV-1/2 (30). However, similar to our results, none of the miRNAs reported in these papers were reported conclusively to be in Ago2 RNA; hence, herpesvirus origin-derived small RNAs represent an area of research that clearly deserves further investigation.…”
Section: Downloaded Frommentioning
confidence: 99%
“…However the differential expression of miRNA has been shown to correlate with the virulence potential of GaHV-1 field strains [27]. While miRNA expressed by BoHV-1 have been identified how expression might varying across the know subtypes or between field strains is yet to be explored [50]. As NGS costs continue to fall there is likely to be increased usage in veterinary studies and as this knowledge base increases it will undoubted lead to improved understanding of disease development and the role of viral genes in this process.…”
Section: Next Generation Sequencing (Ngs)mentioning
confidence: 97%
“…Further there have been no reports investigating the role miRNA expression, either from the host or pathogen perspectives, with respect to BoHV-1 virulence. Glazov et al [50] reported the BoHV-1 miRNA profile in cultured cells. In a separate report Glazov et al [51] reported changes in expression patterns of bovine miRNA in cultured bovine cells infected with BoHV-1 compared to uninfected cells.…”
Section: Vaccination Against Brdmentioning
confidence: 98%