Characterization of nano-hydroxyapatite silica gel and evaluation of its combined effect with Solcoseryl paste on bone formation: An experimental study in New Zealand rabbits

Hamid, Dalia M. Abdel; El-Ghani, Safa F. Abdel; Khashaba, Mohamed M.

doi:10.1016/j.fdj.2018.05.007

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…The results of histology consistence with (Lin K, et al, 2014, Dau M, et al, 2016, Abdel Hamid, D et al, 2018 who monitored the behaviour of Nano Bone by means of histologic and histomorphometric analyses. (39,40,41) The noninvasive (DEXA) and invasive (EDX) methods in BMD measurements of small animals were carried out to complement the information already obtained from histological analysis.…”

Section: Discussionsupporting

confidence: 56%

Association of DEXA with EDX in Evaluation of Inorganic Bone Components After Application of Nano bone For Repair of Bone Defect

Ahmad

Elkilania

2022

Al-Azhar Assiut Dental Journal

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Aim:The aim of this study is to correlate DEXA and EDX in assessment the variations in chemical composition in terms of the main elements comprising the bone mineral {calcium (Ca), and phosphorus (P)} after application of Nano bone for Repair of bone defect. Subjects and Methods: A bone drill defect was created in the right tibia (two holes in each tibia) of 48 rabbits; upper hole was left empty while the lower hole was packed with NanoBone. 24 animals were sacrificed 2 weeks after surgery; the remaining animals were sacrificed after 4 weeks. Half of the bone specimens prepared for the routine laboratory processing, histological and histomorphometric, while The remaining specimens were scanned by Dual-energy X-ray absorptiometry (DEXA) for bone mineral density measurement and then used for bone mineral composition determination by Energy Dispersive X-ray Analyses (EDX). The measurements of DEXA and EDX have been compared after that, data were submitted to ANOVA and Tukey's test. Results: DEXA showed a strong positive correlation with EDX and histological analysis. Conclusion: Energy-dispersive X-ray microanalysis (EDX) is a useful quantitative tool for the analysis of Ca and P in bone in a non-invasive way.

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Section: Discussionsupporting

confidence: 56%

Association of DEXA with EDX in Evaluation of Inorganic Bone Components After Application of Nano bone For Repair of Bone Defect

Ahmad

Elkilania

2022

Al-Azhar Assiut Dental Journal

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In situ assembly of Mt-HAP drug carrier with pH-responsive sustained release properties

Wang

Wen

Xie

et al. 2020

Mater. Res. Express

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The Mt-HAP composites were achieved by combining layered montmorillonite (Mt) and hydroxyapatite (HAP) nanoparticles produced by in situ assembly technique. Amoxicillin (AMX) loading and release experiment proved that the synthetic Mt-HAP composites demonstrated high drug loading ability and pH-responsive sustained release property. The AMX load of original Mt was 18.5 mg g−1, while that of Mt-HAP grew to 49.1 mg g−1. Experiments in simulated gastric fluid (pH 1.2) release indicated that Mt drug carrier having a higher release rate of AMX within the initial 2 h. But after that, the drug release rate of AMX from Mt-HAP has a greater value (about 65% over 12 h) than that of Mt (about 50% over 12 h) because of the dissolution of HAP under acidic circumstance. However, the cumulative sustained release rate of Mt-HAP in simulated intestinal fluid (pH 6.8) over 12 h was only 30%, and the drug release amount of Mt was still about 49%. Compared to Mt@AMX, the drug release rate of Mt-HAP @ AMX is sensitive to changes in pH. The findings claimed that the Mt-HAP composite exhibited extreme potential as a drug carrier for controllable drug delivery.

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A review of bioceramics scaffolds for bone defects in different types of animal models: HA and β -TCP

Kahar¹,

Ahmad²,

Jaafar³

et al. 2022

Biomed. Phys. Eng. Express

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Increased life expectancy has led to an increase in the use of bone substitutes in numerous nations, with over two million bone-grafting surgeries performed worldwide each year. A bone defect can be caused by trauma, infections, and tissue resections which can self-heal due to the osteoconductive nature of the native extracellular matrix components. However, natural self-healing is time-consuming, and new bone regeneration is slow, especially for large bone defects. It also remains a clinical challenge for surgeons to have a suitable bone substitute. To date, there are numerous potential treatments for bone grafting, including gold-standard autografts, allograft implantation, xenografts, or bone graft substitutes. Tricalcium phosphate (TCP) and hydroxyapatite (HA) are the most extensively used and studied bone substitutes due to their similar chemical composition to bone. The scaffolds should be tested in vivo and in vitro using suitable animal models to ensure that the biomaterials work effectively as implants. Hence, this article aims to familiarize readers with the most frequently used animal models for biomaterials testing and highlight the available literature for in vivo studies using small and large animal models. This review summarizes the bio ceramic materials, particularly HA and β-TCP scaffolds, for bone defects in small and large animal models. Besides, the design considerations for the pre-clinical animal model selection for bone defect implants are emphasized and presented.

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Characterization of nano-hydroxyapatite silica gel and evaluation of its combined effect with Solcoseryl paste on bone formation: An experimental study in New Zealand rabbits

Cited by 4 publications

References 29 publications

Association of DEXA with EDX in Evaluation of Inorganic Bone Components After Application of Nano bone For Repair of Bone Defect

Association of DEXA with EDX in Evaluation of Inorganic Bone Components After Application of Nano bone For Repair of Bone Defect

In situ assembly of Mt-HAP drug carrier with pH-responsive sustained release properties

A review of bioceramics scaffolds for bone defects in different types of animal models: HA and β -TCP

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