Characterization of neuronal cell death in normal and diabetic rats following exprimental focal cerebral ischemia

Wang, Guixia; Li, Guang-Ren; Wang, Ying-Di; Yang, Tao; Ouyang, Yi‐Bing

doi:10.1016/s0024-3205(01)01354-6

Cited by 37 publications

(21 citation statements)

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“…Therefore, other factors may underlie the higher mortality/ morbidity and worse outcome of stroke in diabetic patients. It is currently clear that cells dying after brain ischemia is due to both necrosis and/or apoptosis (Wang et al, 2001), which are different modes of cell death. Necrosis is characterized by irreversible swelling of the cytoplasm and organelles and eventually loss of membrane integrity resulting in cell lysis and release of noxious cellular constituents.…”

Section: Introductionmentioning

confidence: 99%

“…It plays a major role in normal growth and differentiation of organ systems and appears to be involved in a variety of human disorders (Barr and Tomei, 1994;Thompson, 1995). Apoptosis, as one process of cell death, has been implicated in cerebral ischemic injury (Cao et al, 2001;Charriaut-Marlangue et al, 1998;Chen et al, 1998;Luo et al, 2002;Namura et al, 1998;Pulera et al, 1998;Wang et al, 2001;Yin et al, 2002). Cerebral neuronal apoptosis in diabetes may also occur without preceding ischemic stroke (Britton et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Diabetes enhances apoptosis induced by cerebral ischemia

Britton

Sima

et al. 2004

Life Sciences

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diabetes enhances apoptosis induced by cerebral ischemia

Britton

Sima

et al. 2004

Life Sciences

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“…Miyata et al (2006) have reported that STZ induced diabetic rodents showed cognitive impairment, depressive and anxiety behavior. Brain damage following cerebral ischemia/reperfusion was worsened distinctly under diabetic conditions (Wang et al, 2001). Type 1 diabetes mellitus results in brain disturbances like hypersensitivity to stress, cognitive disturbance, increased risk of stroke and dementia.…”

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confidence: 99%

Effect of streptozotocin induced diabetes on rat hippocampus

Pamidi

Nayak²

2013

BLL

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Abstract:Objective: The present study was designed to evaluate the diabetes induced neuronal damage in the hippocampus of the rat brain. Background: Diabetes mellitus is an endocrine metabolic disorder of impaired carbohydrate, fat and protein metabolisms characterized by chronic hyperglycemia. The neurological consequences of diabetes mellitus in the brain have gained attention most recently. Materials and methods: Male albino rats of Wistar strain, aged 30 days were used. The rats were divided into (A) Normal Control (B) Vehicle Control (C) 15 days of Streptozotocin (STZ), (D) 30 days of STZ, (E) 45 days of STZ, (F) 60 days of STZ diabetic groups (n = 6 in each group). Blood glucose levels and body weight were measured before STZ injection, 2 days after STZ injection and on the day of sacrifi ce. At the end of the experimental period rats were scarifi ed and brains were processed for cresyl violet staining and the number of survived neurons in the hippocampus was quantifi ed. Results: Microscopic examination of cresyl violet stained sections of diabetic rat hippocampus showed signifi cant and reliable changes. There was a signifi cant difference in the number of survived neurons especially in 30 days of STZ, 45 days of STZ and 60 days of STZ diabetic groups compared to normal control group. Conclusion:The results of our study indicated that diabetic complications can cause rapid damage to the neurons in the hippocampus (Fig. 12, Ref. 22). Full Text in PDF www.elis.sk.

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“…Others have demonstrated a similar outcome with different experimental models as well as in clinical studies. 1,2,[30][31][32][33][34][35] It is established that central nervous system dysfunctions in diabetes are reflected in both structural and functional abnormalities, including impaired cognitive function, [36][37][38][39][40] modest cerebral atrophy, 41,42 and increased occurrence of subcortical and brain stem lesions. [43][44][45] Our studies are supportive of these findings, and we have demonstrated that cerebral infarction was larger in diabetic compared with normoglycemic animals.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of aspirin-induced cerebroprotection by minocycline: A therapeutic approach to attenuate exacerbation of transient focal cerebral ischaemia

Bhatt¹,

Addepalli

2011

Diabetes and Vascular Disease Research

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Cerebrovascular disease is a major cause of mortality and disability in adults. Diabetes mellitus increases the risk of cerebral ischaemia and is associated with worse clinical outcome following an event. Upregulation of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in diabetes appears to play a role in vascular complications of diabetes. We hypothesised that inhibition of MMP-2 and MMP-9 by minocycline can be potentiated by aspirin through inhibition of cyclooxygenase-2 and tissue plasminogen activator, resulting in amelioration of clinical cerebral ischaemia in diabetes. In the present study, cerebral ischaemia/reperfusion injury was induced in streptozotocin diabetic rats by 1 h middle cerebral artery occlusion and 24 h reperfusion. Infarct volume, cerebral oedema, neurological severity score and blood-brain barrier disruption were significantly increased in diabetic animals compared with the normoglycemic control group. The combination of aspirin and minocycline treatment significantly improved these parameters in diabetic animals. Moreover, this therapy was associated with significantly lower mortality and reduction in MMP-2 and MMP-9 levels. Our data indicate that combination of aspirin and minocycline therapy protects from the consequences of cerebral ischaemia in animal models of diabetes and is associated with inhibition of MMP-2 and MMP-9. Therefore, this combination therapy may represent a novel strategy to reduce the neurological complications of cerebral ischaemia in diabetes.

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Characterization of neuronal cell death in normal and diabetic rats following exprimental focal cerebral ischemia

Cited by 37 publications

References 0 publications

Diabetes enhances apoptosis induced by cerebral ischemia

Diabetes enhances apoptosis induced by cerebral ischemia

Effect of streptozotocin induced diabetes on rat hippocampus

Potentiation of aspirin-induced cerebroprotection by minocycline: A therapeutic approach to attenuate exacerbation of transient focal cerebral ischaemia

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