Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China

Zhang, Hongliang; Leng, Chaoliang; Ding, Yushan; Zhai, Hongyue; Li, Zhen; Xiang, Lirun; Zhang, Wenli; Liu, Chunxiao; Li, Minhua; Chen, Jiazeng; Bai, Yun; Kan, Yunchao; Yao, Lunguang; Peng, Jinmei; Wang, Qian; Tang, Yan-Dong; An, Tongqing; Cai, Xuehui; Tian, Zhen; Tong, Guangzhi

doi:10.1007/s00705-018-4080-7

Cited by 43 publications

(51 citation statements)

References 35 publications

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“…All of the recombination sites are within genes encoding Nsp1β, Nsp2, ORF4 and ORF5. The recombination patterns of NADC34‐like PRRSV are complex, consistent with that of the NADC30‐like virus (Zhang, Leng, et al, ). However, unlike NADC30‐like PRRSV, we did not find that NADC34‐like PRRSV has recombined with local strains in China.…”

Section: Resultssupporting

confidence: 70%

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Song

Zhao

et al. 2020

Transbound Emerg Dis

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Porcine reproductive and respiratory syndrome (PRRS) is a global viral swine disease causing significant economic loss to the pig industry worldwide (Neumann et al., 2005; Wensvoort et al., 1992). The pathogen PRRSV, belonging to the genus Porartevirus in the family Arteriviridae (Kuhn et al., 2016), has a genome that is approximately 15 kb in length, including at least 10 open reading frames (ORFs): ORF1a, 1b, 2a, 2b, 3, 4, 5a and 5-7 (Meulenberg et al., 1997). ORF1a and ORF1b encode pp1a and ppab, respectively, which are cleaved to produce 16 Nsps (non-structural proteins). Other ORFs encode the viral structural proteins GP2a, E,

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Section: Resultssupporting

confidence: 70%

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Song

Zhao

et al. 2020

Transbound Emerg Dis

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“…The distribution of lineage 1 viruses was epidemic mainly in the United States, while unique endemic clusters have developed in some countries (Shi, Lam, Hon, Murtaugh, et al, 2010 The epidemic situation of the lineage 1 viruses has become severe in China in recent years. Since the NADC30-like virus was reported in China in 2013, its geographical distribution has expanded rapidly and it has caused several outbreaks (Guo, Chen, Li, Qiao, & Zhang, 2018;Zhang et al, 2019;Zhou et al, 2015). Here, we systematically investigated the global lineage 1 viruses and expanded the recent introductions and reintroductions of PRRSV into China.…”

Section: Discussionmentioning

confidence: 99%

“…Those viruses originated from Canada and then expanded in the United States (representative variants: NADC30) (Shi, Lemey, et al, 2013). Since the first reports of the NADC30-like strains in 2013 (Zhao et al, 2015;Zhou et al, 2015), the virus rapidly spread to many regions of China with high detection rates reported in some regions (Li et al, 2016;Zhang et al, 2018Zhang et al, , 2019. However, knowledge regarding the epidemiological history of Chinese lineage 1 viruses is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Insights into the evolutionary history and epidemiological characteristics of the emerging lineage 1 porcine reproductive and respiratory syndrome viruses in China

Sun

Chen

Cai

et al. 2020

Transbound. Emerg. Dis.

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“…It is suspected that imported breeding pigs from the US were the source of the virus introduction. It was also shown later that NAD30-like PRRSVs underwent recombination with various co-circulating PRRSV2 strains in China including the classical Chinese PRRSV2, the previous dominant HP-PRRSVs [15,64,65] and even the MLV-related strains such as RespPRRS MLV [66] and the Chinese HP-PRRSV JXA1-R based MLV [16].…”

Section: Asfvmentioning

confidence: 95%

Major swine viral diseases: an Asian perspective after the African swine fever introduction

2020

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Asia is a major pig producer of the world, and at present, African swine fever virus (ASFV) continues to significantly impact the Asian pig industry. Since more than 50% of the world's pig population is in Asia, ASFV outbreaks in Asia will affect the global pig industry. Prior to the introduction of ASF, several outbreaks of major swine viruses occurred in Asia over the last two decades, including porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and foot and mouth disease virus (FMDV). The rapid spreading of those viruses throughout Asia involve many factors such as the various pig production systems and supply chains ranging from backyard to intensive industrial farms, animal movement and animal product trading within and among countries, and consumer behaviors. ASF has notoriously been known as a human-driven disease. Travelers and international trading are the major ASFV-carriers for the transboundary transmission and introduction to naïve countries. Globalization puts the entire pig industry at risk for ASF and other infectious diseases arising from Asian countries. Disease control strategies for the various pig production systems in Asia are challenging. In order to ensure future food security in the region and to prevent the deleterious consequences of ASF and other major viral disease outbreaks, disease control strategies and production systems must be improved and modernized.

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Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China

Cited by 43 publications

References 35 publications

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

A potential endemic strain in China: NADC34‑like porcine reproductive and respiratory syndrome virus

Insights into the evolutionary history and epidemiological characteristics of the emerging lineage 1 porcine reproductive and respiratory syndrome viruses in China

Major swine viral diseases: an Asian perspective after the African swine fever introduction

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