Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Abstract

Problem statement: Seeds of Nigella sativa L., commonly known as black seed, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The seeds of this plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous and oil extracts of the seeds have been shown to possess especially nowadays in pharmaceutical antioxidant, anti-inflammatory, anticancer, analgesic, antimicrobial activities and medicinal and cosmetic applications, sanitary, cosmetic, agricultural and food industries. Approach: The aim of this study was to formulate a new delivery system for dermal and cosmetic application by the incorporation of Nigella sativa essential oil into solid lipid nanoparticles SLN. SLN formulations were prepared following the high-pressure homogenization after starring and ultra-trax homognization techniques using hydrogenated palm oil Softisan 154 and N. sativa essential oil as lipid matrix, sorbitol and water as surfactants. The SLN formulation particle size was determined using Photon Correlation System (PCS). Results: The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and re-crystallization behavior was studied using Differential Scanning Calorimetry (DSC). Data showed a high physical stability for both formulations at various storage temperatures during 3 months of storage. In particular, average diameter of N. sativa essential oilloaded SLN did not vary during storage and increased slightly after freeze-drying the SLN dispersions. Conclusion: Therefore, obtained results showed that the studied SLN formulations are suitable carriers in pharmaceutical and cosmetic fields.

Use of Vegetable Oils to Improve the Sun Protection Factor of Sunscreen Formulations

“…In addition, Korkina et al [41], reviewing the sun protection activity of secondary plant metabolites, suggested that the encapsulation of such plant derivatives into solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) could be a promising strategy to formulate sunscreen products with a lower organic UV-filter content. Several works have reported the successful loading of vegetable oils into SLN and NLC to improve the physicochemical and biological properties of these natural ingredients [43][44][45][46]. Therefore, further studies have been planned to assess the effect of co-loading pomegranate oil, shea oil, and organic UV-filters into lipid nanoparticles and the SPF of the resulting formulations.…”

Hydrodistillation of Nigella Sativa Seed and Analysis of Thymoquinone with HPLC and GC-MS

“…Black seed seeds, commonly known as black seeds, are headaches in traditional medicine by many Asian, Middle Eastern and Far Eastern countries (Salem 2005). It is used to treat cough, abdominal pain, diarrhea, asthma, rheumatism and other diseases (Al-Haj et al 2010). Corek seed has high nutritional value and contains various active chemical components.…”

To Determined Using of Herbal Product in Elderly People

“…This plant has great religious significance in Muslim societies, and Turkey is a predominantly Muslim societ. 37 There is a religious tradition (Hadith) which states "Apart from death, there is no disease for which a remedy cannot be found in black cumin". 38 It has been established in studies performed with different cultures that plants such as ginkgo, garlic and Echinacea have been used by different individuals or groups for their cultural or ethnic associations.…”