Characterization of non-radiolabeled Thyroxine (T4) uptake in cryopreserved rat hepatocyte suspensions: Pharmacokinetic implications for PFOA and PFOS chemical exposure

Selano, Julian; Richardson, Vicki M.; Washington, John W.; Mazur, Chris S.

doi:10.1016/j.tiv.2019.03.022

Cited by 4 publications

(2 citation statements)

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“…PFOA and PFHxA exposure also induced similar changes in T4, T3 and TSH in male rats [61]. For PFOA and PFOS, reduced circulating levels of T4 may be due changes in uptake of T4 as demonstrated in rat hepatocytes [193].…”

Section: Modulates Receptor-mediated Effectsmentioning

confidence: 99%

“…Animal Biosassay In Vitro PFOA Association: [153]; [154]; [155]; [156]; [157] Association: reviewed in [164]; [91]; [165]; [166]; [169]; [170]; [173]; [175]; [191]; [61] No association: [174] Association: [176]; [158]; [175]; [181]; [188]; [189]; [193]; [179]; [180] No association: [182] Long-chain PFAS a PFOS Association: [154]; [155]; [156]; [157]; [160]; reviwed in [163] No Association: [153] Association: [191]; [192] Association: [177]; [175]; [181]; [188]; [189]; [193]; [179]; [180] No association: [182] PFHxS Association: [159]; reviwed in [163] No association: [...…”

Section: Epidemiologicalmentioning

confidence: 99%

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Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

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Section: Modulates Receptor-mediated Effectsmentioning

confidence: 99%