Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy

Aimuzi, Ruxianguli; Luo, Kai; Huang, Rong; Huo, Xiaona; Nian, Min; Ouyang, Fengxiu; Du, Yu‐Cang; Feng, Liping; Wang, Weiye; Zhang, Jun

doi:10.1016/j.envpol.2020.114557

Cited by 49 publications

(28 citation statements)

References 45 publications

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“…Another study aimed at evaluating the relationship between PFAS and maternal thyroid function parameters was the one by Aiumzi et al (74) who performed a large prospective study on a 77) extended the evaluation of a possible relationship between thyroid hormones and maternal thyroid function also to the postpartum period. The participants of a prospective Canadian birth cohort (the APrON Study), were enrolled, and data regarding FT3, FT4, TSH, and TPOAb maternal plasma levels were collected in each trimester and 3-months postpartum.…”

Section: Prenatal Exposure To Pfas: Effects On Maternal and Neonatal Thyroid Functionmentioning

confidence: 99%

Thyroid Disrupting Effects of Old and New Generation PFAS

et al. 2021

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Per- and polyfluoroalkyl substances (PFAS) represent a group of synthetic compounds widely used in industry plants due to their low grade of degradation, surfactant properties, thermic and flame resistance. These characteristics are useful for the industrial production, however they are also potentially dangerous for human health and for the environment. PFAS are persistent pollutants accumulating in waters and soil and recoverable in foods due to their release by food packaging. Humans are daily exposed to PFAS because these compounds are ubiquitous and, when assimilated, they are difficult to be eliminated, persisting for years both in humans and animals. Due to their persistence and potential danger to health, some old generation PFAS have been replaced by newly synthesized PFAS with the aim to use alternative compounds presumably safer for humans and the environment. Yet, the environmental pollution with PFAS remains a matter of concern worldwide and led to large-scale epidemiological studies both on plants’ workers and on exposed people in the general population. In this context, strong concern emerged concerning the potential adverse effects of PFAS on the thyroid gland. Thyroid hormones play a critical role in the regulation of metabolism, and thyroid function is related to cardiovascular disease, fertility, and fetal neurodevelopment. In vitro, ex vivo data, and epidemiological studies suggested that PFASs may disrupt the thyroid hormone system in humans, with possible negative repercussions on the outcome of pregnancy and fetal-child development. However, data on the thyroid disrupting effect of PFAS remain controversial, as well as their impact on human health in different ages of life. Aim of the present paper is to review recent data on the effects of old and new generation PFAS on thyroid homeostasis. To this purpose we collected information from in vitro studies, animal models, and in vivo data on exposed workers, general population, and pregnant women.

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Section: Prenatal Exposure To Pfas: Effects On Maternal and Neonatal Thyroid Functionmentioning

confidence: 99%

Thyroid Disrupting Effects of Old and New Generation PFAS

et al. 2021

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“…Effects were milder in pregnant women with normal TPOAb levels [ 85 ]. However, in a recent US study, TPOAb positive women had a negative association between PFAS exposure and TSH levels [ 81 ], inconsistent with other studies reporting a positive association [ 75 , 76 , 82 , 83 , 85 ]. The authors noted that this discrepancy could be a result of study design differences, particularly iodide status of their study population, which affects TH synthesis [ 81 , 85 ].…”

Section: Pfas Exposure and Risk Of Gestational Diabetes Mellitus (Gdm) Development And Candidate Biomarkers: Evidence In The Literaturementioning

confidence: 91%

“…There were 13 individual studies reviewed that measured the associations of PFAS and THs in maternal circulation [ 75 – 87 ], with ten (77%) finding a positive or negative association [ 75 , 76 , 79 – 85 , 87 ] (Table 1 , Supplemental Tables 5–7 ). Berg and colleagues published two studies examining associations of PFAS with maternal TH levels using the same cohort.…”

Section: Pfas Exposure and Risk Of Gestational Diabetes Mellitus (Gdm) Development And Candidate Biomarkers: Evidence In The Literaturementioning

confidence: 99%

“…Of the six studies that performed a subanalysis stratifying women by thyroid antibody status, all six reported that maternal thyroid autoimmunity altered PFAS disruption of the thyroid based on effect measure modification (Supplemental Table 8 ) [ 75 , 79 – 82 , 85 ]. In these studies, it is not presumed that PFAS increased autoimmunity but that PFAS may exacerbate the autoimmune damage to further dysregulate TH production [ 79 , 82 , 85 ].…”

Section: Pfas Exposure and Risk Of Gestational Diabetes Mellitus (Gdm) Development And Candidate Biomarkers: Evidence In The Literaturementioning

confidence: 99%

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A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

et al. 2021

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Per- and polyfluoroalkyl substances (PFAS) have been found to be associated with gestational diabetes mellitus (GDM) development, a maternal health disorder in pregnancy with negative effects that can extend beyond pregnancy. Studies that report on this association are difficult to summarize due to weak associations and wide confidence intervals. One way to advance this field is to sharpen the biologic theory on a causal pathway behind this association, and to measure it directly by way of molecular biomarkers. The aim of this review is to summarize the literature that supports a novel pathway between PFAS exposure and GDM development. Epidemiological studies demonstrate a clear association of biomarkers of thyroid hormones and glucose metabolism with GDM development. We report biologic plausibility and epidemiologic evidence that PFAS dysregulation of maternal thyroid hormones and thyrotropin (TSH) may disrupt glucose homeostasis, increasing the risk of GDM. Overall, epidemiological studies demonstrate that PFAS were positively associated with TSH and negatively with triiodothyronine (T3) and thyroxine (T4). PFAS were generally positively associated with glucose and insulin levels in pregnancy. We propose dysregulation of thyroid function and glucose metabolism may be a critical and missing component in the accurate estimation of PFAS on the risk of GDM.

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“…The universal exposure to PFAS in pregnant women has been reported from different regions worldwide ( Aimuzi et al. 2020 ; Han et al.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

Gao

Luo

Zhang

et al. 2022

Environ Health Perspect

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Background: Pregnant women are ubiquitously exposed to per- and polyfluoroalkyl substances (PFAS). Prenatal exposure to PFAS has been associated with lower birth weight but also with excess adiposity and higher weight in childhood. These mixed findings warrant investigation of the relationship between PFAS and dynamic offspring growth. Objectives: To investigate the association between prenatal PFAS exposure and early-life growth trajectories during the first 2 y. Methods: Pregnant women ( ) were recruited from 2013 to 2016 from the Shanghai Birth Cohort (SBC) Study, and their children were followed up from birth to 2 y of age. Seven PFAS congeners were quantified in pregnant women’s serum during the first trimester. Our study population was restricted to 1,350 children who had five repeated measurements for at least one anthropometric measure. Four anthropometric measures, including weight, length/height, weight-for-length, and head circumference, were evaluated at birth, 42 d, 6 months, 12 months, and 24 months, and standardized into z -scores using the World Health Organization reference. Trajectories of each measure were classified into five groups using group-based trajectory modeling. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for trajectory groups according to -transformed PFAS concentrations, and the moderate-stable group was selected as the reference group for all measures. Results: Higher prenatal exposure to PFAS was associated with elevated odds for the low-rising weight-for-age z -score (WAZ) trajectory, and the high-rising length-for-age z -score (LAZ) trajectory. Meanwhile, PFAS levels were associated with decreased odds for the low-rising and high-rising weight-for-length z -score (WLZ) trajectories. In addition, the associations of PFAS with growth trajectory groups differed by sex, where males had greater odds for the low-rising and low-stable WAZ trajectories and for the high-stable and low-rising WLZ trajectories. In contrast, inverse associations were consistently observed with trajectories of the high-stable, low-stable, and low-rising head-circumference-for-age z -score (HCZ) in relation to most individual PFAS congeners. PFAS mixtures analysis further confirmed the above findings. Discussion: Trajectory analysis approach provided insight into the complex associations between PFAS exposure and offspring growth. Future studies are warranted to confirm the present findings with trajectory modeling strategies and understand the clinical significance of these trajectory groups. https://doi.org/10.1289/EHP9875

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Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy

Cited by 49 publications

References 45 publications

Thyroid Disrupting Effects of Old and New Generation PFAS

Thyroid Disrupting Effects of Old and New Generation PFAS

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

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