Characterization of oligosaccharide-functionalized hyperbranched poly(ethylene imine) and their complexes with retinol in aqueous solution

Bekhradnia, Sara; Naz, Iram; Lund, Reidar; Effenberg, Christiane; Appelhans, Dietmar; Sande, Sverre Arne; Nyström, Bo

doi:10.1016/j.jcis.2015.07.042

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…Backfolded maltose units in G4-DOTA-Mal, inducing the presence of amino groups for Cu(II) coordination in the outer sphere. No core–shell structure, resembling the “fluffy model” of the open-shell architecture of maltose-modified hyperbranched poly(ethyleneimine) (right) . Part structure (dendron) of G4-DOTA-Mal for exemplifying Cu(II) coordination.…”

Section: Resultsmentioning

confidence: 99%

DOTA Glycodendrimers as Cu(II) Complexing Agents and Their Dynamic Interaction Characteristics toward Liposomes

et al. 2020

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Copper (Cu)(II) ions, mainly an excess amount, play a negative role in the course of several diseases, like cancers, neurodegenerative diseases, and the so-called Wilson disease. On the contrary, Cu(II) ions are also capable of improving anticancer drug efficiency. For this reason, it is of great interest to study the interacting ability of Cu(II)− nanodrug and Cu(II)−nanocarrier complexes with cell membranes for their potential use as nanotherapeutics. In this study, the complex interaction between 1,4,7,10-tetraazacyclododecan-N,N′,N′′,N′′′-tetraacetic acid (DOTA)-functionalized poly(propyleneimine) (PPI) glycodendrimers and Cu(II) ions and/or neutral and anionic lipid membrane models using different liposomes is described. These interactions were investigated via dynamic light scattering (DLS), ζ-potential (ZP), electron paramagnetic resonance (EPR), fluorescence anisotropy, and cryogenic transmission electron microscopy (cryo-TEM). Structural and dynamic information about the PPI glycodendrimer and its Cu(II) complexes toward liposomes was obtained via EPR. At the binding site Cu−N 2 O 2 coordination prevails, while at the external interface, this coordination partially weakens due to competitive dendrimer−liposome interactions, with only small liposome structural perturbation. Fluorescence anisotropy was used to evaluate the membrane fluidity of both the hydrophobic and hydrophilic parts of the lipid bilayer, while DLS and ZP allowed us to determine the distribution profile of the nanoparticle (PPI glycodendrimer and liposomes) size and surface charge, respectively. From this multitechnique approach, it is deduced that DOTA-PPI glycodendrimers selectively extract Cu(II) ions from the bioenvironment, while these complexes interact with the liposome surface, preferentially with even more negatively charged liposomes. However, these complexes are not able to cross the cell membrane model and poorly perturb the membrane structure, showing their potential for biomedical use.

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Section: Resultsmentioning

confidence: 99%

DOTA Glycodendrimers as Cu(II) Complexing Agents and Their Dynamic Interaction Characteristics toward Liposomes

et al. 2020

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“…The possibility that the polysaccharides might sequester the retinol in a kind of molecular complex within the overall formulation has been suggested. For example, it has been demonstrated that certain oligosaccharide/polyethylenimine copolymers can form sequestered complexes with retinol in aqueous solution [18]. The behavior of the retinol in aqueous solution would be quite different than its behavior in the colloidal emulsified formulations used in the study.…”

Section: Extended Skin Hydration Regression Study Responsementioning

confidence: 99%

Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides

Gruber

Stojkoska²,

Riemer³

2020

Cosmetics

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It is common that retinoids used in skincare can cause skin dryness, irritation and redness which is a complaint for the use of these molecules in skincare formulations. Objective: to investigate the influence of a mixture of polysaccharides to improve retinol-based formulations in a 12-day inner volar forearm study. Methods: in total, 22 inner volar forearms were treated over a 12-day topical application of a Placebo formulation containing 0.5% retinol verses a formulation containing 0.5% retinol and 3.0% of a complex of polysaccharides. Application occurred 2X/day in the morning and evening. Skin testing included barrier disruption, erythema, and skin hydration. After a 3-day regression of treatment, skin hydration was measured again. Results: the 0.5% retinol Placebo formulation showed a significant impact on skin dehydration compared to untreated control or polysaccharide-treated areas. The formulation containing retinol and 3.0% of the polysaccharides, maintained skin hydration levels comparable to the untreated control. Neither formulation had a statistically significant impact on skin erythema or barrier disruption. After the 3-day regression, the polysaccharide mixture continued to demonstrate significant moisturization benefits superior to the untreated and active-treated sites. Conclusions: a mixture of polysaccharides was able to mitigate the short-term skin drying effects of retinol and continued to moisturize the skin after a 3-Day regression.

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“…introduced mono-and oligosaccharide units on the PEI surface by reductive amidation or N-carboxyanhydride polymerization [129,130]. These defined novel oligosaccharide architectures on dendritic polymer surfaces have been studied as nano-sized carrier systems for gene delivery [131,132] or metal nanoparticles [133,134].…”

Section: Hbps and Multiarm Sps From Peimentioning

confidence: 99%

Improved epoxy thermosets by the use of poly(ethyleneimine) derivatives

Acebo

Ramis

Serra

2017

Physical Sciences Reviews

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Epoxy resins are commonly used as thermosetting materials due to their excellent mechanical properties, high adhesion to many substrates and good heat and chemical resistances. This type of thermosets is intensively used in a wide range of fields, where they act as fiber-reinforced materials, general-purpose adhesives, high-performance coatings and encapsulating materials. These materials are formed by the chemical reaction of multifunctional epoxy monomers forming a polymer network produced through an irreversible way. In this article the improvement of the characteristics of epoxy thermosets using different hyperbranched poly(ethyleneimine) (PEI) derivatives will be explained.Postprint (published version

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Characterization of oligosaccharide-functionalized hyperbranched poly(ethylene imine) and their complexes with retinol in aqueous solution

Cited by 9 publications

References 35 publications

DOTA Glycodendrimers as Cu(II) Complexing Agents and Their Dynamic Interaction Characteristics toward Liposomes

DOTA Glycodendrimers as Cu(II) Complexing Agents and Their Dynamic Interaction Characteristics toward Liposomes

Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides

Improved epoxy thermosets by the use of poly(ethyleneimine) derivatives

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