Characterization of oral disintegrating film of peanut skin extract—Potential route for buccal delivery of phenolic compounds

Tedesco, Marcela Perozzi; Monaco-Lourenço, Carla A.; Carvalho, Rosemary Aparecida de

doi:10.1016/j.ijbiomac.2017.01.044

Cited by 45 publications

(13 citation statements)

References 42 publications

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“…Peanut seeds, skin, and derived products contain phenolic compounds in significant quantities, which contribute to prominent antioxidant capacity (de Camargo et al., ; Sales & Resurreccion, ; Tedesco, Monaco‐Lourenço, & Carvalho, ). Enhanced production of phenolic acids was reported in peanut plants during early growth stages (Sobolev, Horn, Potter, Deyrup, & Gloer, ), and/or in plants exposed to various microbial elicitors (Devi & Reddy, ; Sobolev, ).…”

Section: Bioactive Compounds Make Peanut a Functional Foodmentioning

confidence: 99%

Peanut (Arachis hypogaea L.): A Prospective Legume Crop to Offer Multiple Health Benefits Under Changing Climate

Akram

Shafiq

Ashraf

2018

Comp Rev Food Sci Food Safe

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Peanut is a multipurpose oil-seed legume, which offer benefits in many ways. Apart from the peanut plant's beneficial effects on soil quality, peanut seeds are nutritious and medicinally and economically important. In this review, insights into peanut origin and its domestication are provided. Peanut is rich in bioactive components, including phenolics, flavonoids, polyphenols, and resveratrol. In addition, the involvement of peanut in biological nitrogen fixation is highly significant. Recent reports regarding peanut responses and N 2 fixation ability in response to abiotic stresses, including drought, salinity, heat stress, and iron deficiency on calcareous soils, have been incorporated. As a biotechnological note, recent advances in the development of transgenic peanut plants are also highlighted. In this context, regulation of transcriptional factors and gene transfer for the development of stress-tolerant peanut genotypes are of prime importance. Above all, this review signifies the importance of peanut cultivation and human consumption in view of the scenario of changing world climate in order to maintain food security.

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Section: Bioactive Compounds Make Peanut a Functional Foodmentioning

confidence: 99%

Peanut (Arachis hypogaea L.): A Prospective Legume Crop to Offer Multiple Health Benefits Under Changing Climate

Akram

Shafiq

Ashraf

2018

Comp Rev Food Sci Food Safe

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“…Several polymers can be used in the production of oral films, among the multiplicity of biocompatible polymers used to deliver active compounds, and Vuddanda et al 20 reported that polysaccharides are preferred in the pharmaceutical industry due to their greater compatibility, stability and ease of changing their physicochemical properties when mixed with others biopolymers. Carboxymethylcellulose (CMC), [21][22][23] hydroxypropyl methylcellulose (HPMC) [24][25][26][27] and starch 28,29 are macromolecules commonly used in the preparation of oral films because of their high commercial availability, low cost, good film-forming capacity, and for being nontoxic, among others.…”

Section: Introductionmentioning

confidence: 99%

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

Lourenço

Garcia

Borges

et al. 2022

J of Applied Polymer Sci

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Oral films perform promising alternatives to traditional oral delivery systems to carry and deliver bioactive compounds directly into the oral cavity. The objective of this work was to produce and evaluate oral films based on carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC) and pregelatinized starch incorporated with ethanolic extract from camu-camu industrial residue (EECCIR). Although all films can be ingested without causing irritation to the oral mucosa, due to near-neutral surface pH, the starchbased oral films with and without the addition of EECCIR showed reduced tensile strength (5.48 ± 0.97 MPa) indicating inferior mechanical properties to films based on CMC and HPMC. The CMC films, in addition to shorter disintegration time (50 ± 5 s), showed faster release, about 70% of phenolic compounds in 10 min and 100% in 30 min. As for the release profile, the application of the Korsmeyer and Peppas and Peppas and Sahlin models allowed to better understand the mechanisms involved in the release of phenolic compounds. Although all three oral film formulations can be used as carriers of active compounds from the ethanolic extract of the camu-camu residue, the oral films based on CMC incorporated with EECCIR showed greater potential.

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“…Este alimento possui uma alta concentração de polifenóis, os quais atuam como antioxidantes e reduzem a inflamação das artérias coronárias. Além disso, o amendoim contém uma quantidade considerável da coenzima Q10, nutriente este que fortalece o coração e o protege em condições de redução do fornecimento de oxigênio (Tedesco et al, 2017).…”

Section: Introductionunclassified

Composição físico-química e compostos bioativos do extrato aquoso de amendoim sem pele e enriquecido com pele

Oliveira

Almeida

Gomes

et al. 2021

Braz. J. Food Technol.

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Resumo Objetivou-se realizar a caracterização físico-química e dos compostos bioativos do extrato aquoso de amendoim sem pele e acrescido de 1% de pele. Os extratos aquosos de amendoim sem e com pele foram caracterizados quanto aos parâmetros: umidade, extrato seco total, cinzas, lipídios, proteínas, teor de sólidos solúveis, acidez titulável, pH, carboidrato e fibras totais, além de compostos fenólicos e flavonoides. Os percentuais de umidade encontrados foram elevados em todas as amostras, resultante de sua base de extrato aquoso produzido na proporção 1:8 (amendoim:água). Observou-se que os extratos aquosos de amendoim sem pele e acrescido de 1% de pele não apresentaram diferença significativa entre si para os parâmetros de pH, como também para sólidos solúveis totais, lipídios e carboidratos. No entanto, a acidez, proteínas, fibras e cinzas apresentaram diferença estatística. Na determinação de compostos fenólicos, notou-se que o extrato aquoso de amendoim com pele apresentou uma quantidade maior quando comparado ao sem pele. Quanto aos flavonoides, a maior quantidade também foi encontrada na amostra com pele, apresentando uma diferença média de 2,52 µg/100 g base úmida. Os extratos aquosos de amendoim com e sem pele mostraram ser uma valiosa alternativa para um melhor aproveitamento do amendoim, proporcionando à população um produto nutricional. A bebida acrescida de 1% de pele enriqueceu o produto quanto ao potencial antioxidante devido às suas maiores concentrações de compostos fenólicos totais e flavonoides.

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Characterization of oral disintegrating film of peanut skin extract—Potential route for buccal delivery of phenolic compounds

Cited by 45 publications

References 42 publications

Peanut (Arachis hypogaea L.): A Prospective Legume Crop to Offer Multiple Health Benefits Under Changing Climate

Peanut (Arachis hypogaea L.): A Prospective Legume Crop to Offer Multiple Health Benefits Under Changing Climate

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

Composição físico-química e compostos bioativos do extrato aquoso de amendoim sem pele e enriquecido com pele

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