Characterization of Pasteurella spp. Strains Isolated from Human Infections

Donnio, Pierre-Yves; Lerestif-Gautier, A.-L.; Avril, J

doi:10.1016/j.jcpa.2003.10.002

Cited by 38 publications

(29 citation statements)

References 24 publications

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“…1), and in nearly all cases death appears to result as a complication from infection acquired through animal exposure. Among the Pasteurella species, P. multocida is the predominant human pathogen encountered, especially in severe disease cases (235,239), although P. canis may be more prevalent with dog bites (48, [246][247][248]. Common symptoms of pasteurellosis in humans from animal bite wounds are swelling (edema), cellulitis (diffuse, localized inflammation with redness and pain), and bloody or suppurative/ purulent exudate (drainage) at the wound site (39, 41, 48, 49, 160,165,241,[249][250][251][252][253][254][255].…”

Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

“…Respiratory infection in humans is relatively uncommon but can occur in patients with chronic pulmonary disease (44,48,152,239,247,(294)(295)(296). In these instances, pasteurellosis can present as severe bilateral consolidating pneumonia and also can cause lymphadenopathy (swelling of the lymph nodes), epiglottitis, and abscess formation (295,297).…”

Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

“…However, there are a few studies where this has been examined retrospectively. In one study, 143 isolates collected from human patients over a 12-year period (1983 to 1994) were biochemically characterized for distribution at the species and subspecies levels as well as capsular groups (239). Most of the isolates were determined to be P. multocida subsp.…”

Section: Transmission and Prevalence Through Contact With Petsmentioning

confidence: 99%

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Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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SUMMARY In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae , Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.

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Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

Section: Pasteurella and Other Pasteurellaceae Diseases In Humans Pasmentioning

confidence: 99%

Section: Transmission and Prevalence Through Contact With Petsmentioning

confidence: 99%

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Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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“…multocida (hereafter referred to as P. multocida) is an economically important opportunistic pathogen of livestock (hemorrhagic septicemia, shipping fever, and atrophic rhinitis), poultry (fowl cholera), wildlife (avian cholera), and laboratory rabbits (snuffles) (1). As a commensal of cats and dogs, P. multocida also is a significant cause of zoonotic abscesses arising mainly from bites or scratches, but it has been increasingly associated with pulmonary disease, sepsis, and meningitis in patients with underlying medical conditions that may compromise their immune status (4,10,13,15,16,20,21,29,30,35,38,48). Although the so-called dermonecrotic toxin synthesized by some P. multocida strains produces atrophic rhinitis, the toxin is not essential for respiratory or systemic disease.…”

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confidence: 99%

Sialic Acid Metabolism and Systemic Pasteurellosis

et al. 2005

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Pasteurella multocida subsp. multocida is a commensal and opportunistic pathogen of food animals, wildlife, and pets and a zoonotic cause of human infection arising from contacts with these animals. Here, an investigation of multiple serotype A strains demonstrated the occurrence of membrane sialyltransferase. Although P. multocida lacks the genes for the two earliest steps in de novo sialic acid synthesis, adding sialic acid to the growth medium resulted in uptake, activation, and subsequent transfer of sialic acid to a membrane acceptor resembling lipooligosaccharide. Two candidate-activating enzymes with homology to Escherichia coli cytidine 5-monophospho-N-acetylneuraminate synthetase were overproduced as histidine-tagged polypeptides. The synthetase encoded by pm0187 was at least 37 times more active than the pm1710 gene product, suggesting pm0187 encodes the primary sialic acid cytidylyltransferase in P. multocida. A sialate aldolase (pm1715) mutant unable to initiate dissimilation of internalized sialic acid was not attenuated in the CD-1 mouse model of systemic pasteurellosis, indicating that the nutritional function of sialate catabolism is not required for systemic disease. In contrast, the attenuation of a sialate uptake-deficient mutant supports the essential role in pathogenesis of a sialylation mechanism that is dependent on an environmental (host) supply of sialic acid. The combined results provide the first direct evidence of sialylation by a precursor scavenging mechanism in pasteurellae and of a potential tripartite ATP-independent periplasmic sialate transporter in any species.

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“…El cuadro clínico más común es la infección de piel y tejidos blandos posterior a una mordedura animal, seguido por infecciones del tracto respiratorio, que afecta en la mayoría de los casos a personas con una enfermedad pulmonar subyacente como la enfermedad pulmonar obstructiva crónica (EPOC) y bronquiectasias, o en ancianos e individuos inmunocomprometidos. Se han descrito infecciones secundarias a diseminación hematógena (osteomielitis y artritis séptica) en pacientes con enfermedades de base como artritis reumatoide y en quienes reciben tratamientos con corticoesteroides 2,5,6 . Se han reportado casos infrecuentes de septicemia, endocarditis y meningitis, con mayor frecuencia en personas mayores de 50 años de edad 7 .…”

Section: Introductionunclassified

Septicemia hemorrágica y empiema pleural por Pasteurella canis

Casallas-Rivera

Faccini-Martínez

Perdomo-Beltrán³

et al. 2016

Rev. chil. infectol.

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Pasteurella canis hemorragic sepsis and empyemaWe report the case of a 56-year-old female patient, with a three-day history of hematemesis, melena, abdominal wall hematoma and epistaxis associated with thrombocytopenia and anemia. Idiopathic thrombocytopenic purpura was diagnosed and she was treated with dexamethasone for four days. The patient developed acute respiratory failure with signs of systemic inflammatory response. Blood and pleural fluid cultures grew Pasteurella canis. This is the first case, to our knowledge, of P. canis empyema associated with hemorrhagic septicemia without epidemiological background and the third case of septicemia caused by P. canis reported in the literature.Key words: Pasteurella, empyema, sepsis.Palabras clave: Pasteurella canis, empiema, septicemia hemorrágica. IntroducciónE l género Pasteurella está conformado por bacterias aerobias-microaerofílicas o anaerobias facultativas que se describen morfológicamente como cocobacilos gramnegativos pleomórficos. En la tinción de Gram se pueden observar como formas cocoides, bacilos cortos o filamentosos con una típica tinción bipolar 1-3 . Habitan en la cavidad oral y tracto gastrointestinal de diversos animales y en el ser humano pueden ser parte de la microbiota del tracto respiratorio superior. Los factores de virulencia están dados por la adherencia al epitelio del tracto respiratorio superior mediada por fimbrias, producción de leucotoxinas que alteran la respuesta celular en el tejido pulmonar, una cápsula de polisacáridos antifagocítica resistente al complemento 4 y la unión a la transferrina garantizando la suplencia de hierro necesaria para el crecimiento bacteriano 1 . El cuadro clínico más común es la infección de piel y tejidos blandos posterior a una mordedura animal, seguido por infecciones del tracto respiratorio, que afecta en la mayoría de los casos a personas con una enfermedad pulmonar subyacente como la enfermedad pulmonar obstructiva crónica (EPOC) y bronquiectasias, o en ancianos e individuos inmunocomprometidos. Se han descrito infecciones secundarias a diseminación hematógena (osteomielitis y artritis séptica) en pacientes con enfermedades de base como artritis reumatoide y en quienes reciben tratamientos con corticoesteroides 2,5,6 . Se han reportado casos infrecuentes de septicemia, endocarditis y meningitis, con mayor frecuencia en personas mayores de 50 años de edad 7 .A continuación, comunicamos el primer caso de una septicemia hemorrágica asociada a un empiema pleural por Pasteurella canis.

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Characterization of Pasteurella spp. Strains Isolated from Human Infections

Cited by 38 publications

References 24 publications

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Sialic Acid Metabolism and Systemic Pasteurellosis

Septicemia hemorrágica y empiema pleural por Pasteurella canis

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