Characterization of Pesticide Exposure in a Sample of Pregnant Women in Ecuador

Handal, Alexis J.; Hund, Lauren; Páez, Maritza; Bear, Samantha; Greenberg, Carolyn; Fenske, Richard A.; Barr, Dana Boyd

doi:10.1007/s00244-015-0217-9

Cited by 25 publications

(11 citation statements)

References 55 publications

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“…To the best of our knowledge, no other study has evaluated the urine concentrations of pyrethroid metabolites in a migrant Mexican population. In comparison to studies outside of Sonora, urinary concentrations of 3PBA were higher than the results obtained from the North Carolina studies by Raymer et al [41] and Arcury et al [38] as well as those reported by Panawet et al [38] in Thailand and a study conducted by Handal et al [40] in Ecuador with rose-workers (Table 5). Meanwhile, urinary concentrations for 4F3PBA and t-DCCA in our exploratory study were higher than the results reported by Handal et al [40] in Ecuador, but they were not reported in the other farmworker studies [38,39,41] (Table 5).…”

Section: Discussioncontrasting

confidence: 57%

Migrant Farmworkers’ Exposure to Pesticides in Sonora, Mexico

López-Gálvez

Wagoner

Beamer

et al. 2018

IJERPH

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Expanding agribusiness in Sonora, a state in Northern Mexico, has increased the demand for temporary migrant agricultural workers. Sonora is one of the top states in Mexico for pesticide utilization. We conducted an exploratory study to evaluate exposure to organophosphate (OP) and pyrethroid pesticides among migrant farmworkers. A sample of 20 migrant farmworkers was recruited from a large commercial grape farm during the harvest season. We administered a questionnaire on work activities, exposure characteristics, and socio-demographics. We collected urine samples to quantify pesticide metabolite concentrations. Most participants were originally from the state of Chiapas, Mexico, none had completed high school, and about half spoke an indigenous language as well as Spanish. The majority of participants had detectable concentrations of pyrethroid and organophosphate biomarkers. Geometric mean creatinine-adjusted concentrations for 3-phenoxybenzoic acid (1.83 µg/g), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (0.88 µg/g), 4-fluoro-3-phenoxybenzoic acid (0.94 µg/g), 3,5,6-trichloro-2-pyridinol (3.56 µg/g), and para-nitrophenol (0.63 µg/g) were significantly higher than in the general United States’ population and Mexican Americans. Our results also suggest that migrant farmworkers in this region are exposed to pesticides at higher levels than other farmworkers’ studies. Farmworkers’ age, language, training on personal protective equipment, time at the farm, and season, were significant exposure determinants.

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Section: Discussioncontrasting

confidence: 57%

Migrant Farmworkers’ Exposure to Pesticides in Sonora, Mexico

López-Gálvez

Wagoner

Beamer

et al. 2018

IJERPH

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“…Urinary metabolites of OPPs, i.e., DAPs, have short half-lives ranging from 2 to 15.5 h [ 17 , 18 ]. One study on Japanese pregnant women reported intra-class correlation coefficients (ICCs) to be 0.42–0.55 [ 21 ], while studies conducted in other countries provided −0.01–0.52 [ 51 , 56 , 57 , 58 ]. According to the rule of thumb, an ICC of 0.4 is categorised as “moderate” [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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“… 36 Another study reported elevated thiourea levels in pregnant agricultural rose workers in Ecuador. 37 …”

Section: Discussionmentioning

confidence: 99%

Development and validation of the PEPPER framework (Prenatal Exposure PubMed ParsER) with applications to food additives

Boland

Kashyap

Xiong

et al. 2018

Journal of the American Medical Informatics Association

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BackgroundGlobally, 36% of deaths among children can be attributed to environmental factors. However, no comprehensive list of environmental exposures exists. We seek to address this gap by developing a literature-mining algorithm to catalog prenatal environmental exposures.MethodsWe designed a framework called PEPPER Prenatal Exposure PubMed ParsER to a) catalog prenatal exposures studied in the literature and b) identify study type. Using PubMed Central, PEPPER classifies article type (methodology, systematic review) and catalogs prenatal exposures. We coupled PEPPER with the FDA’s food additive database to form a master set of exposures.ResultsWe found that of 31 764 prenatal exposure studies only 53.0% were methodology studies. PEPPER consists of 219 prenatal exposures, including a common set of 43 exposures. PEPPER captured prenatal exposures from 56.4% of methodology studies (9492/16 832 studies). Two raters independently reviewed 50 randomly selected articles and annotated presence of exposures and study methodology type. Error rates for PEPPER’s exposure assignment ranged from 0.56% to 1.30% depending on the rater. Evaluation of the study type assignment showed agreement ranging from 96% to 100% (kappa = 0.909, p < .001). Using a gold-standard set of relevant prenatal exposure studies, PEPPER achieved a recall of 94.4%.ConclusionsUsing curated exposures and food additives; PEPPER provides the first comprehensive list of 219 prenatal exposures studied in methodology papers. On average, 1.45 exposures were investigated per study. PEPPER successfully distinguished article type for all prenatal studies allowing literature gaps to be easily identified.

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Characterization of Pesticide Exposure in a Sample of Pregnant Women in Ecuador

Cited by 25 publications

References 55 publications

Migrant Farmworkers’ Exposure to Pesticides in Sonora, Mexico

Migrant Farmworkers’ Exposure to Pesticides in Sonora, Mexico

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Development and validation of the PEPPER framework (Prenatal Exposure PubMed ParsER) with applications to food additives

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