Characterization of pH-sensitive chitosan/hydroxypropyl methylcellulose composite nanoparticles for delivery of melatonin in cancer therapy

Jafari, Hessam; Hassanpour, Mehdi; Akbari, Ali; Rezaie, Jafar; Gohari, Gholamreza; Mahdavinia, Gholam Reza; Jabbari, Esmaiel

doi:10.1016/j.matlet.2020.128818

Cited by 25 publications

(19 citation statements)

References 11 publications

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“…Deionized water (DIW) was used for this investigation. Cs–NPs were prepared according to a published method [ 25 ]. Briefly, a Cs solution was obtained by adding 0.5 g of Cs powder to 25 mL of 1% (by wgt) acetic acid with continuous stirring for 3 h at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Chitosan–Selenium Nanoparticle (Cs–Se NP) Foliar Spray Alleviates Salt Stress in Bitter Melon

et al. 2021

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Salt stress severely reduces growth and yield of plants. Considering the positive effects of selenium (Se) and chitosan (Cs) separately against abiotic stress, in these experiments, we synthesized chitosan–selenium nanoparticles (Cs–Se NPs) and investigated their ability to reduce the negative effects of salt stress on growth and some biochemical parameters of bitter melon (Momordica charantia). Bitter melon plants were grown at three NaCl salinity levels (0, 50, and 100 mM) and a foliar spray of Cs–Se NPs (0, 10, and 20 mg L−1) was applied. Some key morphological, biochemical, and physiological parameters in leaf samples and essential oil from fruit were measured at harvest. Salinity decreased growth and yield while foliar application of Cs–Se NPs increased these critical parameters. Furthermore, Cs–Se NPs enhanced bitter melon tolerance to salinity by increasing antioxidant enzyme activity, proline concentration, relative water content, and K+, and decreasing MDA and H2O2 oxidants and Na aggregation in plant tissues. Yield was also improved, as the highest amount of essential oils was produced by plants treated with Cs–Se NPs. Generally, the greatest improvement in measured parameters under saline conditions was obtained by treating plants with 20 mg L−1 Cs–Se NPs, which significantly increased salinity tolerance in bitter melon plants.

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Section: Methodsmentioning

confidence: 99%

Chitosan–Selenium Nanoparticle (Cs–Se NP) Foliar Spray Alleviates Salt Stress in Bitter Melon

et al. 2021

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“…Among the natural polysaccharides, chitosan (CS) has attracted much attention in medical fields [ 11 , 12 ] and is widely used for the loading and release of 5-Fu. CS-decorated nanoemulsion gel used for the topical delivery of 5-Fu was reported by the group of Lim [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Evaluation of Graphene Oxide/Hydroxypropyl Cellulose/Chitosan Hybrid Aerogel for 5-Fluorouracil Release

Sang

Miao

Chen

et al. 2022

Gels

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The incorporation of graphene oxide (GO) into a polymeric drug carrier can not only enhance the loading efficiency but also reduce the initial burst and consequently improve the controllability of drug release. Firstly, 5-fluorouracil (5-Fu)-loaded hydroxypropyl cellulose/chitosan (HPC/CS@5-Fu) and GO/HPC/CS@5-Fu aerogels were successfully fabricated through chemical cross-linking with glutaraldehyde. Then, the obtained aerogels were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FITR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetry (TG), and the effect of HPC and GO content on the drug loading (DL) and encapsulation efficiency (EE) for the two aerogels were investigated, respectively. Finally, the drug release behavior of the GO/HPC/CS@5-Fu aerogels with different GO content was evaluated at two different pH values, and four kinds of kinetic models were used to evaluate the release behavior.

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“…To further confirm Exo biogenesis and alteration under T2DM, we performed an AChE assay for BAL samples. Higher AChE activities in diabetic BAL suggest an increase in the amount of secreted Exo 37 . Based on previous data, the changes in the levels of glucose can alter Exo biogenesis.…”

Section: Discussionmentioning

confidence: 60%

“…Higher AChE activities in diabetic BAL suggest an increase in the amount of secreted Exo. 37 Based on previous data, the changes in the levels of glucose can alter Exo biogenesis. For example, under hypoglycemic conditions cardiomyocytes release high levels of Exo enriched with specific cargo.…”

Section: Discussionmentioning

confidence: 98%

Type 2 diabetes mellitus stimulated pulmonary vascular inflammation and exosome biogenesis in rats

Rezaie

Hosseinpour

Rahbarghazi‬

et al. 2022

Cell Biochemistry & Function

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It has been shown that type 2 Diabetes Mellitus (T2DM) changes the paracrine activity of several cell types. Whether the biogenesis of exosomes is changed during diabetic conditions is the subject of debate. Here, we investigated the effect of T2M on exosome biogenesis in rat pulmonary tissue. Rats received a high‐fat diet regime and a single low dose of Streptozocin to mimic the T2DM‐like condition. A total of 8 weeks after induction of T2DM, rats were subjected to several analyses. Besides histological examination, vascular cell adhesion molecule 1 (VCAM‐1) levels were detected using immunohistochemistry (IHC) staining. Transcription of several genes such as IL‐1β, Alix, and Rab27b was calculated by real‐time polymerase chain reaction assay. Using western blot analysis, intracellular CD63 levels were measured. The morphology and exosome secretion activity were assessed using acetylcholinesterase (AChE) assay and scanning electron microscopy, respectively. Histological results exhibited a moderate‐to‐high rate of interstitial pneumonia with emphysematous changes. IHC staining showed an increased VCAM‐1 expression in the diabetic lungs compared with the normal conditions (p < .05). Likewise, we found the induction of IL‐1β, and exosome‐related genes Alix and Rab27b under diabetic conditions compared with the control group (p < .05). Along with these changes, protein levels of CD63 and AChE activity were induced upon the initiation of T2DM, indicating accelerated exosome biogenesis. Taken together, current data indicated the induction of exosome biogenesis in rat pulmonary tissue affected by T2DM. It seems that the induction of inflammatory niche is touted as a stimulatory factor to accelerate exosome secretion.

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Characterization of pH-sensitive chitosan/hydroxypropyl methylcellulose composite nanoparticles for delivery of melatonin in cancer therapy

Cited by 25 publications

References 11 publications

Chitosan–Selenium Nanoparticle (Cs–Se NP) Foliar Spray Alleviates Salt Stress in Bitter Melon

Chitosan–Selenium Nanoparticle (Cs–Se NP) Foliar Spray Alleviates Salt Stress in Bitter Melon

Fabrication and Evaluation of Graphene Oxide/Hydroxypropyl Cellulose/Chitosan Hybrid Aerogel for 5-Fluorouracil Release

Type 2 diabetes mellitus stimulated pulmonary vascular inflammation and exosome biogenesis in rats

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