Characterization of Physical and Mechanical Properties of Miscible Lactose‐Sugars Systems

Li, Runjing; Roos, Yrjö H.; Miao, Song

doi:10.1111/1750-3841.13831

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…The above characterizations show that, in addition to significant amounts of small molecular products obtained, the fluid obtained from the conversion and dissolution of solid biomass is mainly composed of dimers and trimers of monosaccharides and lignin units, which could be one favorable stream for further upgrading. In fact, the catalytic conversion of dimers and trimers have been widely investigated in previous studies to mimic biomass conversion,[ 61 , 62 , 63 ] while in the present work, dimers and trimmers are obtained directly from raw biomass, representing the actual structure of raw biomass. Thus another fractionation method of biomass conversion starting from the fluid obtained might be possible overcoming the bottleneck of engineering obstacles of mass and heat transfer as well as the use of solid heterogeneous catalysts in previously studied fractionation starting from solid actual biomass.…”

Section: Resultsmentioning

confidence: 99%

Complete Low‐Temperature Transformation and Dissolution of the Three Main Components in Corn Straw

et al. 2023

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The conversion of biomass faces the challenge of mass and heat transfer, as well as the exertion of heterogeneous catalyst, because raw biomass exists usually in solid state. In this work, the simultaneous transformation and dissolution of the three main components (hemicellulose, cellulose, lignin) in corn straw were achieved in ethanol/ valerolactone (GVL)/H 2 O (10 : 10 : 40, v / v / v ) co‐solvent system. With the assistance of AlCl 3 ⋅ 6H 2 O, the conversion of hemicellulose, lignin and cellulose was >96 % at 170 °C. The conversion of solid biomass into fluid, overcoming the mass transfer restrictions between solid biomass and solid catalysts, provides new raw materials to further upgrading. H 2 O could penetrate inside the crystalline cellulose to swell even dissolve it, while ethanol and GVL acted as media to dissolve especially the G unit in lignin. The H + derived from AlCl 3 ⋅ 6H 2 O hydrolysis could break the linkages of lignin‐hemicellulose and glycosidic bond in saccharides, and aluminum chloride promoted the next degradation of polysaccharides to small molecules. Consequently, as high as 33.2 % yield of levulinic acid and 42.2 % yield of furfural were obtained. The cleavage of β‐O‐4 and C β −C γ bonds in lignin produced large amounts of lignin‐derived dimers and trimers. The total yield of monomeric phenols is up to 8 %.

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Section: Resultsmentioning

confidence: 99%

Complete Low‐Temperature Transformation and Dissolution of the Three Main Components in Corn Straw

et al. 2023

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“…a) Physical Properties (Li, Roos, and Miao 2017) Appearance: Clear and Transparent b) Determination of pH (Singh, Kumar, and Prasad 2018) The acidity or alkalinity of an aqueous solution is traditionally represented by the pH value. The glass electrode was used to determine the pH value of a solution potentiometrically.…”

Section: Formulation Of Syrupsmentioning

confidence: 99%

Ibuprofen syrup made by mixed solubilization technique

Thakur¹,

Tripathi²,

Badwaik³

et al. 2022

ijhs

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The aim of the present study was to prepare a liquid dosage form (syrup) of a NSAID (ibuprofen) by mixed solvency technique. The syrup formulation was prepared by using mixed hydrotropic method in which potassium citrate, sodium citrate, potassium acetate and disodium hydrogen phospahte were used as hydrotropes. Glycerine and tween 80 were also used in the formulation. The syrup was prepared by agitation method. At first solubility of the model drug Ibuprofen was identified by dissolving it with different hydrotropes. It was observed that the solubility of ibuprofen increased with increase in concentration of the hydrotropes. However, it is difficult to develop a formulation with very concentration of hydrotropes. Therefore, co-solvent and surfactants were also added to enhance the solubility of the ibuprofen. Glycerine and tween 80 were used along with blends of hydrotropes to increase the solubility of Ibuprofen. The results, showed 3000 times increase in solubility of the ibuprofen drug. Also, the drug content of the prepared formulation was found to be 99.67% which proved the mixed solubilizing technique as a efficient and stable method for development of pharmaceutical dosage forms.

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“…Generally valid relationships could not be derived so far. It is not yet possible to predict the glass transition behavior for random sugar mixtures [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Investigation on the Glass Transition Temperature of Binary and Ternary Sugar Mixtures and the Applicability of Gordon–Taylor and Couchman–Karasz Equation

Schugmann

Foerst

2022

Foods

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Glass transition temperatures (Tg) of carbohydrate mixtures consisting of only one monomer and glycosidic binding type (aldohexose glucose, α1-4-glycosidic bonded) were studied by differential scanning calorimetry (DSC). The aim of this work was to systematically assess the predictability of Tg of anhydrous binary and ternary sugar mixtures focusing on the components Tg, molecular chain length, and shape. Binary systems were investigated with glucose as a monosaccharide and its linear di-, tri-, tetra-, penta-, hexa-, and heptasaccharides. Additionally, the Tg of ternary carbohydrate systems prepared with different glucose/maltose/maltotriose mass fractions were studied to evaluate the behavior of more complex mixtures. An experimental method to prepare fully amorphized, anhydrous mixtures were developed which allows the analysis of mixtures with strongly different thermodynamic pure-component properties (Tg, melting temperature, and degradation). The mixtures’ Tg is systematically underestimated by means of the Couchman–Karasz model. A systematic, sigmoidal deviation behavior from the Gordon–Taylor model could be found, which we concluded is specific for the investigated glucopolymer mixtures. At low concentrations of small molecules, the model underestimates Tg, meeting the experimental values at about equimolarity, and overestimates Tg at higher concentrations. These deviations become more pronounced with increasing Tg differences and were explained by a polymer mixture-specific, nonlinear plasticizing/thermal volume expansion effect.

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Characterization of Physical and Mechanical Properties of Miscible Lactose‐Sugars Systems

Cited by 6 publications

References 48 publications

Complete Low‐Temperature Transformation and Dissolution of the Three Main Components in Corn Straw

Complete Low‐Temperature Transformation and Dissolution of the Three Main Components in Corn Straw

Ibuprofen syrup made by mixed solubilization technique

Systematic Investigation on the Glass Transition Temperature of Binary and Ternary Sugar Mixtures and the Applicability of Gordon–Taylor and Couchman–Karasz Equation

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