Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Lee, Ting Hun; Lee, Chia Hau; Azmi, Nurul Alia; Kavita, Supparmaniam; Wong, Syieluing; Znati, Mansour; Jannet, Hichem Ben

doi:10.1002/cbdv.201900419

Cited by 29 publications

(18 citation statements)

References 34 publications

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“…As such, the effect of its antioxidants after oral administration is not fully known. EBN's anti-oxidant properties are attributed to the pool of bioactive compounds such as amino acids, sialic acid, triacylglycerol, vitamins, lactoferrin, fatty acids, minerals, and glucosamine (Liu et al, 2012;Zainab et al, 2013;Lee et al, 2020). The anti-oxidative effect of EBN showed the presence of two main constituents, namely ovotransferrin and lactoferrin (Hou et al, 2015).…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Edible Bird’s Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia–A Review

et al. 2021

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Edible Bird’s Nest (EBN) is the most prized health delicacy among the Chinese population in the world. Although some scientific characterization and its bioactivities have been studied and researched, no lights have been shed on its actual composition or mechanism. The aim of this review paper is to address the advances of EBN as a therapeutic animal bioproduct, challenges and future perspectives of research involving EBN. The methodology of this review primarily involved a thorough search from the literature undertaken on Web of Science (WoS) using the keyword “edible bird nest”. Other information were obtained from the field/market in Malaysia, one of the largest EBN-producing countries. This article collects and describes the publications related to EBN and its therapeutic with diverse functional values. EBN extracts display anti-aging effects, inhibition of influenza virus infection, alternative traditional medicine in athletes and cancer patients, corneal wound healing effects, stimulation of proliferation of human adipose-derived stem cells, potentiate of mitogenic response, epidermal growth factor-like activities, enhancement of bone strength and dermal thickness, eye care, neuroprotective and antioxidant effects. In-depth literature study based on scientific findings were carried out on EBN and its properties. More importantly, the future direction of EBN in research and development as health-promoting ingredients in food and the potential treatment of certain diseases have been outlined.

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Section: Antioxidant Effectsmentioning

confidence: 99%

Edible Bird’s Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia–A Review

et al. 2021

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“…Briefly, after HMG was done, the triglyceride fraction from EBN was extracted with acetone water mixture (ratio of 75:25) at room temperature for 2 days. The aqueous solution was then obtained after solvent evaporation under a vacuum that was successively partitioned with ethyl acetate (Hun et al, 2020). One of the important factors for EBN nutrients retention is the pH value during acid extraction (Hun et al, 2020).…”

Section: Industrial Edible Bird's Nest Processing Optimised With Laboratory Findingsmentioning

confidence: 99%

Edible Bird’s Nest: Recent Updates and Industry Insights Based On Laboratory Findings

Chok

et al. 2021

Front. Pharmacol.

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Edible bird’s nest (EBN) is a traditional Chinese delicacy made of the saliva of swiftlets found in Southeast Asia. With increasing demands for EBN, quality control of EBN products is important for safe consumption. The processing steps are particularly important for efficient extraction of bioactive compounds. Geographical location, collection place, and harvesting season contribute to differences in nutritional contents in EBN. Concerns regarding presence of adulterant, chemical, and microbial contaminants in EBN as well as authentication and chemical composition measuring methods are discussed in this review. Recent discoveries of beneficial health functions of EBN in antimicrobial and antiviral actions, immunomodulation, cancer prevention and treatment, tissue regeneration, cardiometabolic maintenance, antioxidant action and neuroprotection are also reviewed. Our review provides an update on the recent research on EBN.

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“…EBN mainly consists of protein (almost 60%), carbohydrate (25%) (Daud et al, 2019), moisture, fat, and ash (Amiza et al, 2019;Hun Lee et al, 2020;Hui Yan et al, 2021). At present, the potential bioactive ingredients in EBN with anti-viral and immunomodulatory properties are glycoprotein or glycopeptides.…”

Section: Bioactive Ingredients In Ebnmentioning

confidence: 99%

“…The hydrolysates of EBN contained high level of N-acetylneuraminic acid with profound anti-oxidant effects (Gan et al, 2020). The degree of hydrolysis was the highest when EBN was enzymatically treated with alcalase (Amiza et al, 2019;Zulkifli et al, 2019;Hui Yan et al, 2021), recovering a high level of bioactive Siamuc-glycopeptide (Hui Yan et al, 2021), and amino acids including valine, serine, aspartic acid, phenylalanine, tyrosine, histidine, threonine, and leucine (Babji et al, 2018;Noor et al, 2018;Amiza et al, 2019;Hun Lee et al, 2020). In line with this, the anti-oxidant activity of enzymatically treated EBN was significantly higher, especially alcalase compared to just boiled EBN (Babji et al, 2018;Zulkifli et al, 2019).…”

Section: Bioactive Ingredients In Ebnmentioning

confidence: 99%

The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical Application

et al. 2021

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Edible bird’s nest (BN) is a Chinese traditional medicine with innumerable health benefits, including anti-viral, anti-inflammatory, neuroprotective, and immunomodulatory effects. A small number of studies have reported the anti-viral effects of EBN against influenza infections using in vitro and in vivo models, highlighting the importance of sialic acid and thymol derivatives in their therapeutic effects. At present, studies have reported that EBN suppresses the replicated virus from exiting the host cells, reduces the viral replication, endosomal trafficking of the virus, intracellular viral autophagy process, secretion of pro-inflammatory cytokines, reorient the actin cytoskeleton of the infected cells, and increase the lysosomal degradation of viral materials. In other models of disease, EBN attenuates oxidative stress-induced cellular apoptosis, enhances proliferation and activation of B-cells and their antibody secretion. Given the sum of its therapeutic actions, EBN appears to be a candidate that is worth further exploring for its protective effects against diseases transmitted through air droplets. At present, anti-viral drugs are employed as the first-line defense against respiratory viral infections, unless vaccines are available for the specific pathogens. In patients with severe symptoms due to exacerbated cytokine secretion, anti-inflammatory agents are applied. Treatment efficacy varies across the patients, and in times of a pandemic like COVID-19, many of the drugs are still at the experimental stage. In this review, we present a comprehensive overview of anti-viral and anti-inflammatory effects of EBN, chemical constituents from various EBN preparation techniques, and drugs currently used to treat influenza and novel coronavirus infections. We also aim to review the pathogenesis of influenza A and coronavirus, and the potential of EBN in their clinical application. We also describe the current literature in human consumption of EBN, known allergenic or contaminant presence, and the focus of future direction on how these can be addressed to further improve EBN for potential clinical application.

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Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Cited by 29 publications

References 34 publications

Edible Bird’s Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia–A Review

Edible Bird’s Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia–A Review

Edible Bird’s Nest: Recent Updates and Industry Insights Based On Laboratory Findings

The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical Application

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