Characterization of polyphenolic constituents from Sanguisorba officinalis L. and its antibacterial activity

Zhu, Honglin; Gang, Chen; Chen, Sun-ni; Wang, Qirui; Wan, Ling; Jian, SuPing

doi:10.1007/s00217-019-03276-2

Cited by 25 publications

(24 citation statements)

References 72 publications

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“…In a recent study, Su et al (2019) also reported that bioactive compounds isolated from dried roots extracts of S. officinalis exhibited inhibitory effects against the Gram (−) bacterium Vibrio vulnificus in a dose dependent manner. Similarly to the present study, Zhu et al (2019) observed that purified phenolic compounds extract (PE) from S. officinalis exhibited better activity against Gram (−) bacteria (Escherichia coli and Salmonella typhimurium) than against Gram (+) bacteria (S. aureus, L. monocytogenes and B. subtilis).…”

Section: Antimicrobial Activitysupporting

confidence: 84%

“…(small burnet) and Sanguisorba officinalis L. (great burnet) which are native in the Mediterranean basin and other areas of the world (Gawron-Gzella et al, 2016;Karkanis et al, 2019). The leaves and roots of these species contain a wide variety of bioactive compounds such as gallic acid, ellagic acid, (+)-catechin, lambertianin C, sanguiin H-10, and ziyuglycoside II (Karkanis et al, 2019;Lkhagvasuren & Kim, 2019;Tan et al, 2019;Zhu et al, 2019). So far, it has been well documented that isolated bioactive compounds and/or extracts of both species exert a broad spectrum of medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

et al. 2020

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In this study, the chemical characterization and bioactive properties of S. minor cultivated under different fertilization rates (control, half rate and full rate) were evaluated. Twenty-two phenolic compounds were identified, including five phenolic acids, seven flavonoids and ten tannins. Hydrolysable tannins were prevalent, namely Sanguiin H-10, especially in leaves without fertilization (control). Roots of full-rate fertilizer (660 Kg/ha) presented the highest flavonoid content, mainly catechin and its isomers, whereas half-rate fertilizer (330 Kg/ha), presented the highest content of total phenolic compounds, due to the higher amount of ellagitannins (lambertianin C: 84 ± 1 mg/g of dry extract). Antimicrobial activities were also promising, especially against Salmonella typhimurium (MBC = 0.44 mg/mL). Moreover, root samples revealed activity against all tested cell lines regardless of fertilization rate, whereas leaves were effective only against HeLa cell line. In conclusion, S. minor could be a source of natural bioactive compounds, while fertilization could increase phenolic compounds content.

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Section: Antimicrobial Activitysupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

et al. 2020

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“…Fragmentation of the primary ions resulted in losses of hexose (162 Da), pentose (146 Da), and deoxyhexose (308 Da) [24]. Of the 9 flavonols initially suggested for S. officinalis L., only [2,3,12]. In turn, 3 compounds have not been previously described according to the available literature.…”

Section: Introductionmentioning

confidence: 99%

“…Among the 77 compounds, only 36 had previously been identified in S. officinalis L., and they all were methyl-6-O-galloyl-β-d-glucopyranoside (peak 17, 64; m/z 345), pedunculagin1 (18,23,29; m/z 785), galloyl-HHDP-glucose otherwise called corilagin isomer (25,44,55; m/z 633), di-galloyl-glucoside (37; m/z 483), methyl-4,6-digalloyl-β-d-glucopyranoside (50, 62, 71, 88; m/z 497), HHDP-galloyl-glucose (53; m/z 633), ellagic acid pentoside (60, 99; m/z 433), ellagic acid hexoside (67, 68, 102; m/z 463), di-galloyl hexoside (72, 118; m/z 483), galloyl-bis-HHDP-glucose otherwise called potentilin/casuarictin isomer (84,85,95,97,104,106; m/z 935), lambertianin C (86; m/z 1401), ellagic acid (108; m/z 300.99), trigalloyl-HHDP-glucose (92, 114; m/z 937), trigalloyl-β-D-methyl glucoside (115; m/z 649), 3,3 ,4 -O-trimethyl ellagic acid (127, 128; m/z 343), and 3,4 -O-dimethyl ellagic acid (129, 130; m/z 329) [2,3,12]. In turn, 16 compounds had earlier been detected and identified in flowers and fruits of Punica granatum but in this study were for the first time detected in the morphological parts of S. officinalis L. These compounds were referred to as: 2,3-HHDP-(α/β)-glucose (1; m/z 481), HHDP-hexoside(2,3-(S)-Hexahydroxydiphenoyl-d-glucose) (2,4; m/z 481), HHDP-hexoside(1-galloyl-2,3-hexahydroxydiphenoyl-α-glucose) (3; m/z 481), galloyl-hexoside(β-glucogallin) (5; m/z 331), galloyl-hexoside (7)(8)(9)(10)13; m/z 331), di-HHDP-glucoside (34; m/z 783), di-galloyl-HHDP-glucose (14,56,66; m/z 785), galloyl-HHDP-hexoside (77; m/z 633), and pentagalloyl-glucoside (111; m/z 939) [10,13]. Another 6 compounds belonging to the group of hydrolyzable tannins were detected during identification of Duchesnea indica and they were: di-HHDP-glucose also known as pedunculalagin isomer (15,20,24,26,27,…”

Section: Introductionmentioning

confidence: 99%

“…119 and 122 were tentatively identified as sanguiin H-7 and sanguiin H-7 isomers considering their primary ion at m/z 801 and fragmentation peaks at m/z 649 and 301 resulting from the loss of 152, 332, and 16 Da. In contrast, sanguisorbic acids, belonging to the hydrolyzed tannins, also have been previously defined for these plants by Zhu et al [2] as sanguisorbic acid dilactone (9, 12; m/z 469) and sanguisorbic acid glucoside (52; m/z 667). These compounds were determined only in the leaves, stalks, and roots of S. officinalis L. Moreover, 1 sanguisorbigenin, belonging to the triterpenoid saponins, was detected during identification P. granatum [12].…”

Section: Introductionmentioning

confidence: 99%

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Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

et al. 2020

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The aim of this study was to accurately determine the profile of polyphenols using the highly sensitive LC–DAD–ESI–QTOF–MS/MS technique and to determine in vitro antioxidant activity, the ability of inhibition of α-amylase, α-glucoamylase, and pancreatic lipase activity, and antiproliferative activity in leaves, flowers, roots, and stalks of medical plant Sanguisorba officinalis L. The results of the analysis of the morphological parts indicated the presence of 130 polyphenols, including 62 that were detected in S. officinalis L. for the first time. The prevailing group was tannins, with contents ranging from 66.4% of total polyphenols in the flowers to 43.3% in the stalks. The highest content of polyphenols was identified in the flowers and reached 14,444.97 mg/100 g d.b., while the lowest was noted in the stalks and reached 4606.33 mg/100 g d.b. In turn, the highest values of the antiradical and reducing capacities were determined in the leaves and reached 6.63 and 0.30 mmol TE/g d.b, respectively. In turn, a high ability to inhibit activities of α-amylase and α-glucoamylase was noted in the flowers, while a high ability to inhibit the activity of pancreatic lipase was demonstrated in the leaves of S. officinalis L. In addition, the leaves and the flowers showed the most effective antiproliferative properties in pancreatic ductal adenocarcinoma, colorectal adenocarcinoma, bladder cancer, and T-cell leukemia cells, whereas the weakest activity was noted in the stalks. Thus, the best dietetic material to be used when composing functional foods were the leaves and the flowers of S. officinalis L., while the roots and the stalks were equally valuable plant materials.

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LC‐ESI‐QTOF/MS characterization of antimicrobial compounds with their action mode extracted from vine tea (Ampelopsis grossedentata) leaves

Umair

Sultana

Zhu

et al. 2022

Food Science & Nutrition

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Vine tea (Ampelopsis grossedentata) is a tea plant cultivated south of the Chinese Yangtze River. It has anti‐inflammatory properties and is used to normalize blood circulation and detoxification. The leaves of vine tea are the most abundant source of flavonoids, such as dihydromyricetin and myricetin. However, as the main bioactive flavonoid in vine tea, dihydromyricetin was the main focus of previous research. This study aimed to explore the antibacterial activities of vine tea against selected foodborne pathogens. The antimicrobial activity of vine tea extract was evaluated by the agar well diffusion method. Cell membrane integrity and bactericidal kinetics, along with physical damage to the cell membrane, were also observed. The extract was analyzed using a high‐performance liquid chromatography‐diode array detector (HPLC‐DAD), and the results were confirmed using a modified version of a previously published method that combined liquid chromatography and electrospray‐ionized quadrupole time‐of‐flight mass spectrometry (LC‐ESI‐QTOF/MS). Cell membrane integrity and bactericidal kinetics were determined by releasing intracellular material in suspension and monitoring it at 260 nm using an ultraviolet (UV) spectrophotometer. A scanning electron microscope (SEM) was used to detect morphological alterations and physical damage to the cell membrane. Six compounds were isolated successfully: (1) myricetin (C15H10O8), (2) myricetin 3‐O‐rhamnoside (C21H20O12), (3) 5,7,8,3,4‐pentahydroxyisoflavone (C15H10O7), (4) dihydroquercetin (C15H12O7), (5) 6,8‐dihydroxykaempferol (C15H10O8), and (6) ellagic acid glucoside (C20H16O13). Among these bioactive compounds, C15H10O7 was found to have vigorous antimicrobial activity against Bacillus cereus (AS11846) and Staphylococcus aureus (CMCCB26003). A dose‐dependent bactericidal kinetics with a higher degree of absorbance at optical density 260 (OD260) was observed when the bacterial suspension was incubated with C15H10O7 for 8 h. Furthermore, a scanning electron microscope study revealed physical damage to the cell membrane. In addition, the action mode of C15H10O7 was on the cell wall of the target microorganism. Together, these results suggest that C15H10O7 has vigorous antimicrobial activity and can be used as a potent antimicrobial agent in the food processing industry.

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Characterization of polyphenolic constituents from Sanguisorba officinalis L. and its antibacterial activity

Cited by 25 publications

References 72 publications

Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

LC‐ESI‐QTOF/MS characterization of antimicrobial compounds with their action mode extracted from vine tea (Ampelopsis grossedentata) leaves

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