Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

Kurahashi, Toshifumi; Furukawa, Junya; Kumano, Masafumi; Takenaka, Atsushi; Fujisawa, Masato

doi:10.1007/s11255-009-9578-1

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…However, the incidence rate was much lower in most of the Asian countries. According to the recent studies with 1207 cases from Asia, the prevalence of incidental prostate cancer was only about 10.9% [13], [19]–[25]. It was extremely low in China, Japan and India.…”

Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer at the Time of Cystectomy: The Incidence and Clinicopathological Features in Chinese Patients

et al. 2014

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ObjectivesTo evaluate the incidence and the clinicopathological features of incidental prostate cancer detected in radical cystoprostatectomy (RCP) specimens in Chinese men and to estimate the oncological risk of prostate apex-sparing surgery for such patients.MethodsThe clinical data and pathological feature of 504 patients who underwent RCP for bladder cancer from January 1999 to March 2013 were retrospectively reviewed. Whole mount serial section of the RCP specimens were cut transversely at 3–4 mm intervals and examined in same pathological institution.ResultsThirty-four out of 504 patients (6.8%) had incidental prostate cancer with a mean age of 70.3 years. 12 cases (35.2%) were diagnosed as significant disease. 4 cases were found to have apex involvement of adenocarcinoma of the prostate while in 5 cases the prostate stroma invasion by urothelial carcinoma were identified (one involved prostate apex). The mean follow-up time was 46.4±33.8 months. Biochemical recurrence occurred in 3 patients but no prostate cancer-related death during the follow-up. There was no statistical significance in cancer specific survival between the clinically significant and insignificant cancer group.ConclusionsThe prevalence of incidental prostate cancer in RCP specimens in Chinese patients was remarkably lower than in western people. Most of the incidental prostate cancer was clinically insignificant and patient's prognosis was mainly related to the bladder cancer. Sparing the prostate apex was potentially associated with a 1.0% risk of leaving significant cancer of the prostate or urothelial carcinoma.

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Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer at the Time of Cystectomy: The Incidence and Clinicopathological Features in Chinese Patients

et al. 2014

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“…Lee et al [22] shows that just for 4% of all 248 studied patients incidentally found prostate cancer was found in Taiwan. A bit more cases of incidentally found cancer were found in the Kurahashi et al [23] study. Incidentally found cancer after RCP was diagnosed for 33.3% of all examined patients in our study.…”

Section: Discussionmentioning

confidence: 99%

Incidentally Found Prostate Cancer and Influence on Overall Survival after Radical Cystoprostatectomy

et al. 2012

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Objectives. To determine incidentally found prostate cancer frequency and impact on overall survival after RCP. Patients and Methods. The records of 81 men who underwent cystoprostatectomy from January 2000 to December 2009 were reviewed. The vital status of the study group was assessed as on September 1, 2009, by passive followup, using data from the population registry. Results. The 81 men underwent RCP. The incidental prostate cancer was found in the specimens of 27 (33.3%) patients. 13 (48.1%) of 27 prostate cancer cases were clinically significant. For 3 patients (11.1%) an extraprostatic extension was found. For 2 patients (7.4%)—positive margins, for 1 patient (3.7%)—Gleason sum 8, and for the rest 7 patients bigger than 0.5 cm3 volume tumor, and Gleason sum 7 was found. The mean follow-up time was 39.2 ± 33.8 months (varies from 0.8 to 131.2 months). The patients with bladder cancer and incidentally found prostate cancer lived shorter (28.1 ± 27.5 and 45.5 ± 35.40 months). Higher overall survival (P = 0.03) was found in the patient group with bladder cancer without incidentally diagnosed prostate cancer. Conclusion. There are indications that in this small study prostate cancer has influenced on patients' survival with bladder cancer after radical cystoprostatectomy.

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“…The prevalence of incidental PCa varied among countries and cohorts, even though all the studies were carried out in similar periods, ranging from 1988 to 2008. Among all the studies carried out, the prevalence was consistently high in Japan and Korea (12.3% and 26.1%, and 51.7% and 50.0%, respectively). In the studies on incidental PCa, tumor grade was evaluated using the Gleason score.…”

Section: Prevalence Of Latent and Incidental Prostate Cancer In Asianmentioning

confidence: 94%

“…Table summarizes the results of studies on latent and incidental PCa in Asian men. Pathological examinations were carried out using 3–5‐mm step sections in all the studies, with the exception of a study on incidental cancer from Iran . The majority of the latent cancer studies reported on Japanese men, except for two studies from Singapore and Iran.…”

Section: Prevalence Of Latent and Incidental Prostate Cancer In Asianmentioning

confidence: 99%

“…Pathological examinations were carried out using 3-5-mm step sections in all the studies, with the exception of a study on incidental cancer from Iran. 5,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The majority of the latent cancer studies reported on Japanese men, except for two studies from Singapore and Iran. Generally, the prevalence of latent cancer in Japanese men has been increasing; the prevalence rates among men were 10.9%, 32 22.5%, 33 19.7%, 35 20.8% 37 and 34.6%, 33 29 The mortality rates were age-standardized using the WHO world standard population.…”

Section: Prevalence Of Latent and Incidental Prostate Cancer In Asianmentioning

confidence: 99%

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Epidemiology of prostate cancer in Asian countries

2018

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The incidence of prostate cancer has been increasing worldwide in recent years. The GLOBOCAN project showed that prostate cancer was the second most frequently diagnosed cancer and the fifth leading cause of cancer mortality among men worldwide in 2012. This trend has been growing even in Asian countries, where the incidence had previously been low. However, the accuracy of data about incidence and mortality as a result of prostate cancer in some Asian countries is limited. The cause of this increasing trend is multifactorial. One possible explanation is changes in lifestyles due to more Westernized diets. The incidence is also statistically biased by the wide implementation of early detection systems and the accuracy of national cancer registration systems, which are still immature in most Asian countries. Mortality rate decreases in Australia, New Zealand and Japan since the 1990s are possibly due to the improvements in treatment and/or early detection efforts employed. However, this rate is increasing in the majority of other Asian countries. Studies of latent and incidental prostate cancer provide less biased information. The prevalence of latent and incidental prostate cancer in contemporary Japan and Korea is similar to those in Western countries, suggesting the influence of lifestyle changes on carcinogenesis. Many studies reported evidence of both congenital and acquired risk factors for carcinogenesis of prostate cancer. Recent changes in the acquired risk factors might be associated with the increasing occurrence of prostate cancer in Asian countries. This trend could continue, especially in developing Asian countries.

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Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

Abstract: Clinicopathological features of incidentally detected prostate cancer are markedly more favorable than those of clinically detected prostate cancer, which may reflect less aggressive biological phenotypes of incidental prostate cancer arising in Japanese men.

Cited by 16 publications

References 27 publications

Incidental Prostate Cancer at the Time of Cystectomy: The Incidence and Clinicopathological Features in Chinese Patients

Incidental Prostate Cancer at the Time of Cystectomy: The Incidence and Clinicopathological Features in Chinese Patients

Incidentally Found Prostate Cancer and Influence on Overall Survival after Radical Cystoprostatectomy

Epidemiology of prostate cancer in Asian countries

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