Characterization of rabies virus from a human case in Nepal

Pant, Ganesh Raj; Horton, Daniel L.; Dahal, Mona; N., J.; Ide, Seiya; Leech, S.; Marston, Denise A.; McElhinney, L. M.; Fooks, Anthony R.

doi:10.1007/s00705-010-0868-9

Cited by 10 publications

(11 citation statements)

References 10 publications

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“…This study used partial sequences of N genes, which might be responsible for different results. Rabies virus from Nepal also belongs to AAL2, and as reported in a previous study ( 15 ), seemed to be forming a different lineage. However, the speculation was not supported by a significant a posterior density value (0.6355).…”

Section: Discussionsupporting

confidence: 69%

Arctic-like Rabies Virus, Bangladesh

Jamil¹,

Ahmed²,

Matsumoto³

et al. 2012

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 69%

Arctic-like Rabies Virus, Bangladesh

Jamil¹,

Ahmed²,

Matsumoto³

et al. 2012

Emerg. Infect. Dis.

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“…Recent studies on the Nepalese field rabies virus indicate that it belongs to the Arctic fox genome [2]. The rabies virus isolated from a human rabies case was 100% identical to viruses isolated from two dogs and a mongoose in Nepal [3]. …”

Section: Introductionmentioning

confidence: 99%

Human Rabies in the WHO Southeast Asia Region: Forward Steps for Elimination

Gongal

Wright

2011

Advances in Preventive Medicine

144

124

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There are eleven Member States in the WHO southeast Asia region (Bangladesh, Bhutan, Democratic People's Republic of Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand, Timor-Leste) of which eight are endemic for rabies. More than 1.4 billion people in the Region are at risk of rabies infection, and approximately 45% of worldwide rabies deaths occur in Asia. Dog bites account for 96% of human rabies cases. Progress in preventing human rabies through control of the disease in dogs has been slow due to various factors. Innovative control tools and techniques have been developed and standardized in recent years. The introduction of cost-effective intradermal rabies vaccination regimens in Asian countries has increased the availability and affordability of postexposure prophylaxis. Elimination of rabies is not possible without regional and intersectoral cooperation. Considering the importance of consolidating achievements in rabies control in Member countries, the WHO Regional Office for southeast Asia has developed a regional strategy for elimination of human rabies transmitted by dogs in the Region. They have committed to provide technical leadership, to advocate national health authorities to develop major stakeholder consensus for a comprehensive rabies elimination programme, and to implement national strategies for elimination of human rabies.

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“…29 (veterinary professional) might be due to lack of booster dose both of them had taken pre-exposure vaccination 1-3 years ago. However other factor such as host ability to immune response, quality of vaccine and health status may influence the production of antibody titer in host [7]. Sample No.…”

Section: Resultsmentioning

confidence: 99%

A Serological Study in Response to People at Occupational Risk of Rabies Virus Exposure in Nepal

Pant¹,

Pant²

2016

J Vaccines Vaccin

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A serological study to know the antibody titer against rabies virus in human beings, who are at occupational risk, was conducted in Nepal in 2014. A total 44 serum samples were collected out of which 21 samples were collected from medical professionals (working at Sukraraj Tropical Hospital) and 23 were collected from veterinary professionals (working at Central Veterinary Hospital, Central Veterinary Laboratory and Rabies Vaccine Production Laboratory) in Kathmandu. Among the 44 samples, 4 were collected from unvaccinated persons. The other 40 people sampled were vaccinated with inactivated rabies vaccine. All samples were subjected to the Rabies Fluorescent Focus Inhibition Test (RFFIT) test at Centre for Disease Control and Prevention, Atlanta, USA. The antibody level of 7 persons was found to be less than the WHO recommended titer of 0.5 IU/ml. Six medical professionals and one veterinary professional had a low rabies virus neutralizing antibody titer. The 4 samples collected from unvaccinated persons, and 3 collected from vaccinated persons had a titer below 0.5 IU/ml. This study shows that medical and veterinary professionals who are responsible to nurse or handle rabies patients, rabid animals or rabies virus are still at high risk. This underscores the importance of recommendations for regular serological testing of occupationally exposed individuals and vaccinating booster dose when necessary.

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Characterization of rabies virus from a human case in Nepal

Cited by 10 publications

References 10 publications

Arctic-like Rabies Virus, Bangladesh

Arctic-like Rabies Virus, Bangladesh

Human Rabies in the WHO Southeast Asia Region: Forward Steps for Elimination

A Serological Study in Response to People at Occupational Risk of Rabies Virus Exposure in Nepal

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